[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
You seem to have javascript disabled. Please note that many of the page functionalities won't work as expected without javascript enabled.
 
 
Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (3,454)

Search Parameters:
Keywords = hybrid positioning

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
24 pages, 8422 KiB  
Article
A Combined Calibration Method for Workpiece Positioning in Robotic Machining Systems and a Hybrid Optimization Algorithm for Improving Tool Center Point Calibration Accuracy
by Daxian Hao, Gang Zhang, Huan Zhao and Han Ding
Appl. Sci. 2025, 15(3), 1033; https://doi.org/10.3390/app15031033 - 21 Jan 2025
Abstract
This paper addresses the machining requirements for large aerospace structural components using robotic systems and proposes a method for rapid workpiece positioning that combines the simplicity of vision-based positioning with the precision of contact-based methods. To enhance the accuracy of robot calibration, a [...] Read more.
This paper addresses the machining requirements for large aerospace structural components using robotic systems and proposes a method for rapid workpiece positioning that combines the simplicity of vision-based positioning with the precision of contact-based methods. To enhance the accuracy of robot calibration, a novel approach utilizing a ruby probe for sphere-to-sphere contact calibration of the Tool Center Point (TCP) is introduced. A robot contact calibration model is formulated, transforming the calibration process into a nonlinear least squares (NLS) optimization problem. To tackle the challenges of NLS optimization, a hybrid LM-D algorithm is developed, integrating the Levenberg–Marquardt (L-M) and DIviding RECTangle (DIRECT) algorithms in an iterative process to achieve the global optimum. This algorithm ensures computational efficiency while maximizing the likelihood of finding a globally optimal solution. An iterative convergence termination criterion for TCP calibration is established to determine global convergence, further enhancing the algorithm’s efficiency. Experimental validation was performed on industrial robots, demonstrating the proposed algorithm’s superior performance in global convergence and iteration efficiency compared to traditional methods. This research provides an effective and practical solution for TCP calibration in industrial robotic applications. Full article
(This article belongs to the Section Robotics and Automation)
Show Figures

Figure 1

Figure 1
<p>The robotic composite machining system.</p>
Full article ">Figure 2
<p>The 3D visual system coarse positioning approach.</p>
Full article ">Figure 3
<p>The schematic of contact probe calibration.</p>
Full article ">Figure 4
<p>The robot sphere-to-sphere calibration process.</p>
Full article ">Figure 5
<p>The L-M algorithm flowchart.</p>
Full article ">Figure 6
<p>The DIRECT algorithm flowchart.</p>
Full article ">Figure 7
<p>The LM-D hybrid algorithm flowchart.</p>
Full article ">Figure 8
<p>Robot TCP calibration experiment using the sphere-to-sphere method.</p>
Full article ">Figure 9
<p>The relation between X, Y parameters and function values of TCP.</p>
Full article ">Figure 10
<p>Convergence illustration for data 1, 2, 3 sets using different algorithms: (<b>a</b>) Convergence of the three data sets calculated using the L-M algorithm. (<b>b</b>) Convergence of the three data sets calculated using the DIRECT algorithm. (<b>c</b>) Convergence of the three data sets calculated using the SA algorithm. (<b>d</b>) Convergence of the three data sets calculated using the LM-D algorithm.</p>
Full article ">Figure 10 Cont.
<p>Convergence illustration for data 1, 2, 3 sets using different algorithms: (<b>a</b>) Convergence of the three data sets calculated using the L-M algorithm. (<b>b</b>) Convergence of the three data sets calculated using the DIRECT algorithm. (<b>c</b>) Convergence of the three data sets calculated using the SA algorithm. (<b>d</b>) Convergence of the three data sets calculated using the LM-D algorithm.</p>
Full article ">Figure 11
<p>The LEONI 6D TCP calibration to check the accuracy of TCP parameters.</p>
Full article ">Figure 12
<p>Calibration accuracy verification experiment using a ruby probe.</p>
Full article ">
21 pages, 2536 KiB  
Article
Phygital Experience Platform for Textile Exhibitions in Small Local Museums
by Supaporn Chai-Arayalert, Supattra Puttinaovarat and Wanida Saetang
Heritage 2025, 8(1), 35; https://doi.org/10.3390/heritage8010035 - 20 Jan 2025
Viewed by 250
Abstract
This study introduces a comprehensive phygital framework tailored for small local museums, addressing the unique challenges of textile exhibitions. By seamlessly integrating physical artifacts with advanced digital tools through a user-centered design–thinking approach, the platform transforms traditional museum visits into hybrid experiences. The [...] Read more.
This study introduces a comprehensive phygital framework tailored for small local museums, addressing the unique challenges of textile exhibitions. By seamlessly integrating physical artifacts with advanced digital tools through a user-centered design–thinking approach, the platform transforms traditional museum visits into hybrid experiences. The research addresses challenges faced by small museums, such as limited interactivity, static information presentation, and resource constraints. The findings demonstrate that the phygital platform significantly enhances visitor satisfaction, usability, and engagement. Features like mobile applications, chatbots, and gamification foster dynamic interactions, increasing interest in historical textile collections. The evaluation highlights positive impacts on visitor learning and accessibility, with high usability scores and favorable feedback confirming the platform’s success. By bridging physical and digital realms, the platform empowers small local museums to modernize their exhibition experience offerings while preserving their authenticity and cultural significance. This study contributes to the growing literature on phygital strategies in museum contexts, offering practical recommendations for implementing such platforms in resource-constrained settings. The findings underscore the potential of phygital approaches to foster deeper connections with cultural heritage, ensure broader accessibility, and support sustainable visitor engagement. Full article
Show Figures

Figure 1

Figure 1
<p>Research framework (adapted from [<a href="#B7-heritage-08-00035" class="html-bibr">7</a>,<a href="#B25-heritage-08-00035" class="html-bibr">25</a>]).</p>
Full article ">Figure 2
<p>Design–thinking approach and system development (adapted from [<a href="#B35-heritage-08-00035" class="html-bibr">35</a>]).</p>
Full article ">Figure 3
<p>Phygital experience platform of the Namuensri Museum case study.</p>
Full article ">Figure 4
<p>Analysis results of respondents’ post-visit experience grouped by aspects.</p>
Full article ">
36 pages, 8910 KiB  
Article
Mapping the Dream: Designing Optimal E-Bike Routes in Valparaíso, Chile, Using a Multicriteria Analysis and an Experimental Study
by Vicente Aprigliano, Catalina Toro, Gonzalo Rojas, Iván Bastías, Marcus Cardoso, Tálita Santos, Marcelino Aurélio Vieira da Silva, Emilio Bustos, Ualison Rébula de Oliveira and Sebastian Seriani
ISPRS Int. J. Geo-Inf. 2025, 14(1), 38; https://doi.org/10.3390/ijgi14010038 - 20 Jan 2025
Viewed by 281
Abstract
The city of Valparaíso, Chile, faces significant mobility challenges due to its steep slopes, complex urban infrastructure, and socioeconomic conditions. In this direction, this study explores the potential promotion of E-bike uses by identifying the optimal routes that connect metro stations to strategic [...] Read more.
The city of Valparaíso, Chile, faces significant mobility challenges due to its steep slopes, complex urban infrastructure, and socioeconomic conditions. In this direction, this study explores the potential promotion of E-bike uses by identifying the optimal routes that connect metro stations to strategic hilltop streets in the city. A hybrid methodology combining a multicriteria GIS-based analysis and an experimental study was used to evaluate potential routes and the possibility of increasing the power limitations for non-motorized mobility in Chile. Fifteen routes were assessed based on criteria including the slope, traffic safety, directionality, intersections, and travel distance. The results indicate that routes such as Cumming from Puerto and Bellavista stand out as the most viable for e-bike use given their favorable characteristics. The experimental study revealed that higher-powered E-bikes (500 W and 750 W) would be more able to overcome the steep slopes of Valparaíso, with an average speed of 5.36 km/h and 9.52 km/h on routes with a 10.88% average slope. These findings challenge the current regulatory limit of 250 W for non-motorized vehicles in Chile, highlighting the potential benefits of increasing their power limits to enhance sustainable mobility in the hilly urban contexts of this country. This study highlights the need to adapt urban mobility policies to the unique topographical conditions of each city. Future research should build upon more experimental studies, develop specific street-scale analyses using audit methods, incorporate climate-related variables, and evaluate the economic viability of e-bike infrastructure. Addressing these aspects could position Valparaíso as a leading example of sustainable urban mobility for cities facing comparable challenges. Full article
Show Figures

Figure 1

Figure 1
<p>Slope map of the city of Valparaíso, indicating areas with slopes greater than and less than 6%. Source: elaborated by the authors.</p>
Full article ">Figure 2
<p>Conditions of the streets in Valparaíso. (<b>a</b>) Templeman Street, between Lautaro Rosas and San Enrique, heading north; (<b>b</b>) Templeman, between Lautaro Rosas and San Enrique, heading south; (<b>c</b>) Urriola. Date: 25 April 2024. Source: elaborated by the authors.</p>
Full article ">Figure 3
<p>Transport contextualization of Valparaiso’s urban limits. Source: elaborated by the authors.</p>
Full article ">Figure 4
<p>Zoning established to separate the routes. Source: elaborated by the authors.</p>
Full article ">Figure 5
<p>Type of intersections. (<b>a</b>) One intersection, for its type and weighting, is considered if it is unidirectional or bidirectional. (<b>b</b>) Two intersections, for their type and weighting, are considered if both are unidirectional or bidirectional. (<b>c</b>) Three intersections. Source: elaborated by the authors.</p>
Full article ">Figure 6
<p>Uphill and downhill routes registered in zone 1. (<b>A</b>) Uphill direction; (<b>B</b>) downhill direction. Source: elaborated by the authors.</p>
Full article ">Figure 7
<p>Bidirectional routes registered in zone 2. Source: elaborated by the authors.</p>
Full article ">Figure 8
<p>Uphill and downhill routes registered in zone 3. (<b>A</b>) Uphill direction; (<b>B</b>) downhill direction. Source: elaborated by the authors.</p>
Full article ">Figure 9
<p>Topographic profile of the route on which the experiment was carried out. Source: elaborated by the authors.</p>
Full article ">Figure 10
<p>Metrics obtained from the sensors and instruments used in the experiments. Time and distance were obtained using the GPS and speed using a Garmin speed sensor. Source: elaborated by the authors.</p>
Full article ">Figure 11
<p>Respondents’ responses to the survey section related to the perception of comfort and safety of each bicycle. Source: elaborated by the authors.</p>
Full article ">Figure 12
<p>Respondents’ responses to the survey section related to physical effort and the ease of use of each bike. Source: elaborated by the authors.</p>
Full article ">Figure A1
<p>Names and locations of Valparaiso’s hills. Source: elaborated by the authors.</p>
Full article ">
27 pages, 751 KiB  
Systematic Review
Hybrid Teaching and Learning in Higher Education: A Systematic Literature Review
by Daina Gudoniene, Evelina Staneviciene, Isabel Huet, Jochen Dickel, Djibril Dieng, Joël Degroote, Vitor Rocio, Rita Butkiene and Diogo Casanova
Sustainability 2025, 17(2), 756; https://doi.org/10.3390/su17020756 - 19 Jan 2025
Viewed by 725
Abstract
Hybrid teaching, which integrates traditional in-person learning based on students’ perspectives where online learning offers a flexible approach to education, combines the benefits of technology with face-to-face interactions. Moreover, teaching and learning in a hybrid way met several challenges for both teachers and [...] Read more.
Hybrid teaching, which integrates traditional in-person learning based on students’ perspectives where online learning offers a flexible approach to education, combines the benefits of technology with face-to-face interactions. Moreover, teaching and learning in a hybrid way met several challenges for both teachers and learners, including technological problems, time management, communication difficulties, and assessment complexities. This systematic review investigates six main research questions: (1) What pedagogical frameworks are used in hybrid teaching and learning? (2) How can we enhance students’ engagement in hybrid teaching and learning? (3) What is the impact of technological integration on hybrid learning scenarios, both for students and teachers? (4) How do training and support measures influence the willingness and ability of university teachers to implement hybrid teaching formats? (5) How do formative assessment and feedback methods in hybrid learning environments enable teachers to effectively monitor student progress and provide tailored support? (6) How does the implementation of hybrid learning affect student learning outcomes? This study identifies the following key themes: technological integration, pedagogical innovation, faculty support, student engagement, assessment practices, and learning outcomes. Our contribution of this literature review is related to teaching and learning by showing teachers the most appropriate way to avoid the challenges encountered when teaching in a hybrid way. These include strong technology integration, innovative pedagogical strategies, strong academic development and support, active student engagement, effective assessment practices, and positive learning outcomes. Full article
(This article belongs to the Special Issue Sustainable Inspiration of Flexible Education—Second Edition)
Show Figures

Figure 1

Figure 1
<p>Prisma framework to obtain the relevant studies.</p>
Full article ">
13 pages, 2458 KiB  
Article
Temperature-Responsive Hybrid Composite with Zero Temperature Coefficient of Resistance for Wearable Thermotherapy Pads
by Ji-Yoon Ahn, Dong-Kwan Lee, Min-Gi Kim, Won-Jin Kim and Sung-Hoon Park
Micromachines 2025, 16(1), 108; https://doi.org/10.3390/mi16010108 - 19 Jan 2025
Viewed by 303
Abstract
Carbon-based polymer composites are widely used in wearable devices due to their exceptional electrical conductivity and flexibility. However, their temperature-dependent resistance variations pose significant challenges to device safety and performance. A negative temperature coefficient (NTC) can lead to overcurrent risks, while a positive [...] Read more.
Carbon-based polymer composites are widely used in wearable devices due to their exceptional electrical conductivity and flexibility. However, their temperature-dependent resistance variations pose significant challenges to device safety and performance. A negative temperature coefficient (NTC) can lead to overcurrent risks, while a positive temperature coefficient (PTC) compromises accuracy. In this study, we present a novel hybrid composite combining carbon nanotubes (CNTs) with NTC properties and carbon black (CB) with PTC properties to achieve a near-zero temperature coefficient of resistance (TCR) at an optimal ratio. This innovation enhances the safety and reliability of carbon-based polymer composites for wearable heating applications. Furthermore, a thermochromic pigment layer is integrated into the hybrid composite, enabling visual temperature indication across three distinct zones. This bilayer structure not only addresses the TCR challenge but also provides real-time, user-friendly temperature monitoring. The resulting composite demonstrates consistent performance and high precision under diverse heating conditions, making it ideal for wearable thermotherapy pads. This study highlights a significant advancement in developing multifunctional, temperature-responsive materials, offering a promising solution for safer and more controllable wearable devices. Full article
(This article belongs to the Special Issue Feature Papers of Micromachines in 'Materials and Processing' 2024)
Show Figures

Figure 1

Figure 1
<p>Schematic illustrations depicting the mechanism of resistance change during Joule heating due to thermal expansion: (<b>a</b>) PDMS-CB composite, (<b>b</b>) PDMS-CNT composite, and (<b>c</b>) PDMS-CNT, CB composite. (<b>d</b>) Temperature-detectable Z-TCR composite used for thermal therapy.</p>
Full article ">Figure 2
<p>Fabrication of bilayer hybrid composites with carbon nanofillers and thermochromic pigments.</p>
Full article ">Figure 3
<p>Percolation threshold graphs of (<b>a</b>) PDMS-CNT composites and (<b>b</b>) PDMS-CB composites.</p>
Full article ">Figure 4
<p>Normalized resistance graphs during Joule heating at 120 °C for 150 s: (<b>a</b>) PDMS-CNT composites and (<b>b</b>) PDMS-CB composites with varying filler content. The SEM images with 64k magnification of (<b>c</b>) PDMS-CNT-1.5 and (<b>d</b>) PDMS-CB-8.5.</p>
Full article ">Figure 5
<p>Normalized resistance graphs during Joule heating at 120 °C for 150 s: (<b>a</b>) graph showing the influence of CB as a PTC filler on PDMS-CNT composites, (<b>b</b>) PDMS-CNT(2 wt%), PDMS-CB(18 wt%), and PDMS-CNT(2 wt%), CB(18 wt%) composites. SEM images of PDMS-CNT(2 wt%), CB(18 wt%) composites with (<b>c</b>) 18.5k and (<b>d</b>) 64.6k magnification.</p>
Full article ">Figure 6
<p>(<b>a</b>) SEM images at 43× magnification of PDMS-CNT(2 wt%), CB(18 wt%). (<b>b</b>) Repeated and rapid on–off thermal responses at an applied voltage of 8 V. (<b>c</b>) Infrared images taken during the repetition of the heating and cooling cycle.</p>
Full article ">Figure 7
<p>(<b>a</b>) Color changes in the bilayer composite across three temperature ranges based on the activation of thermochromic pigments. (<b>b</b>) Correlation between the applied voltage for Joule heating and the corresponding temperature increase. (<b>c</b>) Application of the hybrid bilayer composite for wrist thermotherapy.</p>
Full article ">
16 pages, 28400 KiB  
Article
Compliance Control of a Cable-Driven Space Manipulator Based on Force–Position Hybrid Drive Mode
by Runhui Xiang, Hejie Xu, Xinliang Li, Xiaojun Zhu, Deshan Meng and Wenfu Xu
Aerospace 2025, 12(1), 69; https://doi.org/10.3390/aerospace12010069 (registering DOI) - 19 Jan 2025
Viewed by 328
Abstract
Multi-cable cooperative control is essential for cable-driven space manipulators to achieve in-orbit services such as fault spacecraft maintenance, fuel injection, on-orbit assembly, and orbital garbage removal. To prevent the cables from becoming slack or excessively tight, the force in each cable must be [...] Read more.
Multi-cable cooperative control is essential for cable-driven space manipulators to achieve in-orbit services such as fault spacecraft maintenance, fuel injection, on-orbit assembly, and orbital garbage removal. To prevent the cables from becoming slack or excessively tight, the force in each cable must be distributed appropriately. The force distribution among different cables requires real-time adjustments; otherwise, the system may become unstable. This paper proposes a compliance control method based on the force–position hybrid drive mode to address the challenges of multi-cable cooperative control. Firstly, the mapping relationship between the cable space and the joint space of the cable-driven space manipulator is established. Then, the force mapping relationship for this structure is derived. The control scheme categorizes the cables into two types: active-side cables and antagonistic-side cables. Position control and force control are implemented separately, significantly reducing the computational requirements and enhancing the overall performance of the control system. Finally, the feasibility of the proposed algorithm is demonstrated through simulations and compared with the PID control method. When tracking the same trajectory, the proposed method reduces the tracking error by 49.14% and the maximum force by 58.58% compared to the PID control method, effectively addressing the problem of force distribution in multi-rope coordinated control. Full article
Show Figures

Figure 1

Figure 1
<p>Space manipulator system and equivalent simplified model.</p>
Full article ">Figure 2
<p>Multiple single-joint module structure.</p>
Full article ">Figure 3
<p>Multiple single-joint module simplified diagram.</p>
Full article ">Figure 4
<p>Schematic diagram of control system.</p>
Full article ">Figure 5
<p>Main structure of the manipulator’s Simscape model.</p>
Full article ">Figure 6
<p>Simulink model.</p>
Full article ">Figure 7
<p>(<b>a</b>) Tracking trajectory curve. (<b>b</b>) Tracking error.</p>
Full article ">Figure 8
<p>(<b>a</b>) Cable length variation. (<b>b</b>) Cable tension variation.</p>
Full article ">Figure 9
<p>(<b>a</b>) Joint angular velocity. (<b>b</b>) Joint torque.</p>
Full article ">Figure 10
<p>Joint angle tracking error comparison.</p>
Full article ">Figure 11
<p>Cable force comparison.</p>
Full article ">Figure 12
<p>(<b>a</b>) Drag torque. (<b>b</b>) Actual torque.</p>
Full article ">Figure 13
<p>(<b>a</b>) Drag trajectory. (<b>b</b>) Tracking error.</p>
Full article ">Figure 14
<p>(<b>a</b>) Cable length variation. (<b>b</b>) Cable force.</p>
Full article ">Figure 15
<p>Prototype of joint module.</p>
Full article ">Figure 16
<p>Joint angle, joint angular velocity, and joint angular acceleration.</p>
Full article ">Figure 17
<p>(<b>a</b>) Estimated joint torque. (<b>b</b>) Cable force.</p>
Full article ">Figure 18
<p>(<b>a</b>) Motor position. (<b>b</b>) Motor current.</p>
Full article ">
18 pages, 6204 KiB  
Article
Two-Stage GPR Image Inversion Method Based on Multi-Scale Dilated Convolution and Hybrid Attention Gate
by Mingze Wu, Qinghua Liu and Shan Ouyang
Remote Sens. 2025, 17(2), 322; https://doi.org/10.3390/rs17020322 - 17 Jan 2025
Viewed by 318
Abstract
Ground penetrating radar (GPR) image inversion is of great significance for interpreting GPR data. In practical applications, the complexity and nonuniformity of underground structures bring noise and clutter interference, making GPR inversion problems more challenging. To address these issues, this study proposes a [...] Read more.
Ground penetrating radar (GPR) image inversion is of great significance for interpreting GPR data. In practical applications, the complexity and nonuniformity of underground structures bring noise and clutter interference, making GPR inversion problems more challenging. To address these issues, this study proposes a two-stage GPR image inversion network called MHInvNet based on multi-scale dilated convolution (MSDC) and hybrid attention gate (HAG). This method first denoises the B-scan through the first network MHInvNet1, then combines the denoised B-scan from MHInvNet1 with the undenoised B-scan as input to the second network MHInvNet2 for inversion to reconstruct the distribution of the permittivity of underground targets. To further enhance network performance, the MSDC and HAG modules are simultaneously introduced to both networks. Experimental results from simulated and actual measurement data show that MHInvNet can accurately invert the position, shape, size, and permittivity of underground targets. A comparison with existing methods demonstrates the superior inversion performance of MHInvNet. Full article
(This article belongs to the Special Issue Advanced Ground-Penetrating Radar (GPR) Technologies and Applications)
Show Figures

Figure 1

Figure 1
<p>GPR detection model and data representation.</p>
Full article ">Figure 2
<p>Inversion Process.</p>
Full article ">Figure 3
<p>MHInvNet Structure.</p>
Full article ">Figure 4
<p>MSDC model.</p>
Full article ">Figure 5
<p>HAG model.</p>
Full article ">Figure 6
<p>Denoising and inversion results of different networks.</p>
Full article ">Figure 7
<p>Inversion results of permittivity values at cutting lines ① to ⑥ using different networks.</p>
Full article ">Figure 8
<p>MSDC module visualization.</p>
Full article ">Figure 9
<p>HAG module visualization.</p>
Full article ">Figure 10
<p>Denoising and inversion results of actual measurement data using different networks.</p>
Full article ">Figure 11
<p>Inversion results of permittivity values at cutting lines ① to ⑦ of actual measurement data using different networks.</p>
Full article ">Figure 12
<p>Measurement experiments of measured data in different geographical environments.</p>
Full article ">Figure 13
<p>The denoising and inversion results for the measured data of steel bars by different networks.</p>
Full article ">Figure 14
<p>Inversion results of permittivity values for the measured data of steel bars by different networks.</p>
Full article ">
28 pages, 357 KiB  
Article
Eurafrican Invisibility in Zambia’s Census as an Echo of Colonial Whiteness: The Case for a British Apology
by Juliette Bridgette Milner-Thornton
Genealogy 2025, 9(1), 6; https://doi.org/10.3390/genealogy9010006 - 17 Jan 2025
Viewed by 428
Abstract
In this article, I argue that Eurafricans’ invisibility in Zambia’s national census, history, and social framework is an echo of colonial whiteness stemming from the destructive legacy of illegitimacy perpetuated by British officials in Northern Rhodesia (present-day Zambia) during the colonial era (1924–64), [...] Read more.
In this article, I argue that Eurafricans’ invisibility in Zambia’s national census, history, and social framework is an echo of colonial whiteness stemming from the destructive legacy of illegitimacy perpetuated by British officials in Northern Rhodesia (present-day Zambia) during the colonial era (1924–64), which continues to the present day. This is evidenced by the absence of Eurafricans in the Zambia national censuses. This contribution calls for the British government to apologise to the Eurafrican community for the legacy of illegitimacy and intergenerational racial trauma it bestowed on the community. Zambia’s tribal ‘ethnic’ and ‘linguistics’ census classification options prevent a comprehensive understanding of Zambia’s multi-racial history and the development of a hybrid space that embraces a ‘mixed-race’ Eurafrican (of European and African heritage) Zambian identity. Through an autoethnographic account of my Eurafrican uncle Aaron Milner, I reflect on Zambian Eurafricans’ historical racial positioning as ‘inferior interlopers’, which has contributed to their obscurity in Zambia’s national history and census. However, my reflection goes beyond Milner’s story in Zambia. It is my entryway to highlight how race and colonial whiteness interconnected and underpinned racial ideology in the wider British Empire, and to draw attention to its echoes in various contemporary sociopolitical contexts, including census terminology in Australia and Zambia and Western nations’ anti-Black immigration policies. Full article
21 pages, 21641 KiB  
Article
Hybrid-Driven Dynamic Position Prediction of Robot End-Effector Integrating Parametric Dynamic Model and Machine Learning
by Hepeng Ni, Cong Xu, Yingxin Ye, Bo Chen, Shuangsheng Luo and Shuai Ji
Appl. Sci. 2025, 15(2), 895; https://doi.org/10.3390/app15020895 - 17 Jan 2025
Viewed by 337
Abstract
Accurate dynamic model and response prediction of industrial robots (IRs) are prerequisites for production optimization before actual operation. In this study, a hybrid-driven dynamic position prediction (HDPP) approach integrating a parametric dynamic model (PDM) and learning-based residual error compensators (RECs) is developed to [...] Read more.
Accurate dynamic model and response prediction of industrial robots (IRs) are prerequisites for production optimization before actual operation. In this study, a hybrid-driven dynamic position prediction (HDPP) approach integrating a parametric dynamic model (PDM) and learning-based residual error compensators (RECs) is developed to estimate the actual position of a robot end-effector based on the reference input trajectory. Firstly, a PDM consisting of a flexible dynamic model of the mechanical system and a servo system model is constructed as the primary predictor in HDPP. Meanwhile, a reinforcement learning (RL)-based parameter identification method is presented to obtain independent dynamic parameters, which integrates a CAD model, least squares estimation, and RL. Then, an REC based on the temporal convolutional network long short-term memory (TCN-LSTM) is proposed for each joint to compensate for the residual error after PDM prediction. A TCN is employed as the input of LSTM to extract and compress the discontinuous features, which can enhance the compensator’s accuracy and stability. Additionally, a dynamics-integrated (DI) dataset construction scheme is developed for network training to boost the prediction accuracy. Finally, a series of experiments and comparative analysis are preformed to validate the performance of HDPP in terms of prediction accuracy and stability. Full article
Show Figures

Figure 1

Figure 1
<p>Dynamic position prediction of EE based on reference trajectory.</p>
Full article ">Figure 2
<p>Overall structure of the proposed HDPP.</p>
Full article ">Figure 3
<p>Elastic joint model.</p>
Full article ">Figure 4
<p>Flowchart of parameter tuning based on CARLA.</p>
Full article ">Figure 5
<p>Layout of the experimental system.</p>
Full article ">Figure 6
<p>Test joint trajectories.</p>
Full article ">Figure 7
<p>Simulation and actual motor torques of each motor. (<b>a</b>) Motor 1. (<b>b</b>) Motor 2.</p>
Full article ">Figure 8
<p>Simplified servo system model.</p>
Full article ">Figure 9
<p>Framework of REC based on TCN-LSTM network.</p>
Full article ">Figure 10
<p>Complete structure of a TCN network.</p>
Full article ">Figure 11
<p>Structure of LSTM with multi-memory units.</p>
Full article ">Figure 12
<p>Some of the training paths. (<b>a</b>) Random path. (<b>b</b>) Regular path.</p>
Full article ">Figure 13
<p>Test paths. (<b>a</b>) Heart path. (<b>b</b>) A random path.</p>
Full article ">Figure 14
<p>Prediction results of the heart path with different datasets. (<b>a</b>) Prediction error of joint 1. (<b>b</b>) Prediction error of joint 2. (<b>c</b>) Prediction contour error.</p>
Full article ">Figure 15
<p>Prediction results of the test random path with different datasets. (<b>a</b>) Prediction error of joint 1. (<b>b</b>) Prediction error of joint 2. (<b>c</b>) Prediction contour error.</p>
Full article ">Figure 16
<p>Prediction results of the heart path with different methods. (<b>a</b>) Prediction error of joint 1. (<b>b</b>) Prediction error of joint 2. (<b>c</b>) Prediction contour error.</p>
Full article ">Figure 17
<p>Prediction results of the test random path with different methods. (<b>a</b>) Prediction error of joint 1. (<b>b</b>) Prediction error of joint 2. (<b>c</b>) Prediction contour error.</p>
Full article ">
54 pages, 6031 KiB  
Article
(E)-1-(3-(3-Hydroxy-4-Methoxyphenyl)-1-(3,4,5-Trimethoxyphenyl)allyl)-1H-1,2,4-Triazole and Related Compounds: Their Synthesis and Biological Evaluation as Novel Antimitotic Agents Targeting Breast Cancer
by Gloria Ana, Azizah M. Malebari, Sara Noorani, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer and Mary J. Meegan
Pharmaceuticals 2025, 18(1), 118; https://doi.org/10.3390/ph18010118 - 17 Jan 2025
Viewed by 407
Abstract
Background/Objectives: The synthesis of (E)-1-(1,3-diphenylallyl)-1H-1,2,4-triazoles and related compounds as anti-mitotic agents with activity in breast cancer was investigated. These compounds were designed as hybrids of the microtubule-targeting chalcones, indanones, and the aromatase inhibitor letrozole. Methods: A panel of [...] Read more.
Background/Objectives: The synthesis of (E)-1-(1,3-diphenylallyl)-1H-1,2,4-triazoles and related compounds as anti-mitotic agents with activity in breast cancer was investigated. These compounds were designed as hybrids of the microtubule-targeting chalcones, indanones, and the aromatase inhibitor letrozole. Methods: A panel of 29 compounds was synthesized and examined by a preliminary screening in estrogen receptor (ER) and progesterone receptor (PR)-positive MCF-7 breast cancer cells together with cell cycle analysis and tubulin polymerization inhibition. Results: (E)-5-(3-(1H-1,2,4-triazol-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)-2-methoxyphenol 22b was identified as a potent antiproliferative compound with an IC50 value of 0.39 mM in MCF-7 breast cancer cells, 0.77 mM in triple-negative MDA-MB-231 breast cancer cells, and 0.37 mM in leukemia HL-60 cells. In addition, compound 22b demonstrated potent activity in the sub-micromolar range against the NCI 60 cancer cell line panel including prostate, melanoma, colon, leukemia, and non-small cell lung cancers. G2/M phase cell cycle arrest and the induction of apoptosis in MCF-7 cells together with inhibition of tubulin polymerization were demonstrated. Immunofluorescence studies confirmed that compound 22b targeted tubulin in MCF-7 cells, while computational docking studies predicted binding conformations for 22b in the colchicine binding site of tubulin. Compound 22b also selectively inhibited aromatase. Conclusions: Based on the results obtained, these novel compounds are suitable candidates for further investigation as antiproliferative microtubule-targeting agents for breast cancer. Full article
Show Figures

Graphical abstract

Graphical abstract
Full article ">Figure 1
<p>Drugs for the treatment of breast cancer: SERMs (tamoxifen <b>1a</b>, 4-hydroxytamoxifen <b>1b</b>, endoxifen <b>1c</b>, norendoxifen <b>1d</b>), SERD fulvestrant <b>2</b>, PROTAC elacestrant <b>3</b>, ARV-471 <b>4</b>, aromatase inhibitors (exemestane <b>5</b>, letrozole <b>6</b>, and anastrozole <b>7</b>).</p>
Full article ">Figure 2
<p>Targeted therapies for breast cancer: CDK4/6 inhibitors palbociclib <b>8</b>, ribociclib <b>9</b>, and abemacicilib <b>10</b>, mTOR inhibitor everolimus <b>11</b>; PI3K inhibitor alpelisib <b>12</b>, AKT inhibitor capivasertib <b>13</b>; PARP inhibitors olaparib <b>14</b>, and talazoparib <b>15</b>.</p>
Full article ">Figure 3
<p>Antiproliferative chalcones and related compounds that target the colchicine binding site of tubulin: α-methylchalcones <b>16a–e</b>, O-arylchalcone <b>16f</b>, millepachine <b>17</b>, bischalcone <b>18</b>, combretastatins CA-4 <b>19a</b> and CA-1 <b>19b</b>, and phenstatin <b>19c</b>.</p>
Full article ">Figure 4
<p>Target structures <b>A</b> (chalcone-based) and <b>B</b> (indane-based) for synthesis.</p>
Full article ">Figure 5
<p>Preliminary cell viability data for Series 1: (<b>A</b>) compounds <b>22a–22g</b> and chalcone <b>20b</b> and Series 2: (<b>B</b>) compounds <b>23a–e</b> and chalcone <b>20b</b> in MCF-7 breast cancer cells. Cell proliferation of MCF-7 cells was determined with an alamarBlue assay (seeding density 2.5 × 10<sup>4</sup> cells/mL per well for 96-well plates). Compound concentrations of either 1 or 0.1 μM for 72 h were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% <span class="html-italic">v</span>/<span class="html-italic">v</span>). The mean value ± SEM for three independent experiments is shown. The positive controls used are CA-4 and phenstatin (1.0 μM and 0.1 μM). Statistical analysis was performed using One-way ANOVA with the Sidak multiple comparison test (***, <span class="html-italic">p</span> &lt; 0.001).</p>
Full article ">Figure 6
<p>Preliminary cell viability data for (<b>A</b>) triazoles <b>26a–e</b> and related indanone <b>24a</b> and (<b>B</b>) imidazoles <b>27a–f</b>, <b>27h</b>, <b>27i</b> and related compounds <b>30</b> and <b>33b</b> in MCF-7 breast cancer cells. Cell proliferation of MCF-7 cells was determined with an alamarBlue assay (seeding density 2.5 × 10<sup>4</sup> cells/mL per well for 96-well plates). Compound concentrations of either 1 or 0.1 μM for 72 h were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% <span class="html-italic">v</span>/<span class="html-italic">v</span>). The mean value ± SEM for three independent experiments is shown. The positive controls used were CA-4 and phenstatin (1.0 μM and 0.1 μM). Statistical test was performed using One-way ANOVA with Sidak multiple comparison test (***, <span class="html-italic">p</span> &lt; 0.001).</p>
Full article ">Figure 6 Cont.
<p>Preliminary cell viability data for (<b>A</b>) triazoles <b>26a–e</b> and related indanone <b>24a</b> and (<b>B</b>) imidazoles <b>27a–f</b>, <b>27h</b>, <b>27i</b> and related compounds <b>30</b> and <b>33b</b> in MCF-7 breast cancer cells. Cell proliferation of MCF-7 cells was determined with an alamarBlue assay (seeding density 2.5 × 10<sup>4</sup> cells/mL per well for 96-well plates). Compound concentrations of either 1 or 0.1 μM for 72 h were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% <span class="html-italic">v</span>/<span class="html-italic">v</span>). The mean value ± SEM for three independent experiments is shown. The positive controls used were CA-4 and phenstatin (1.0 μM and 0.1 μM). Statistical test was performed using One-way ANOVA with Sidak multiple comparison test (***, <span class="html-italic">p</span> &lt; 0.001).</p>
Full article ">Figure 7
<p>Preliminary cell viability data for (<b>A</b>) triazoles <b>22b–d</b>, <b>22f</b>, <b>22g</b> and imidazole <b>23d</b> and (<b>B</b>) triazoles <b>26a–e</b> and imidazoles <b>27a</b>, <b>27b</b>, <b>27e</b>, <b>27f</b>, <b>27h</b> and <b>27i</b> in HL-60 cells. Cell proliferation of HL-60 cells was determined with an alamarBlue assay (seeding density 2.5 × 10<sup>4</sup> cells/mL per well for 96-well plates). Compound concentrations of either 1 or 0.1 μM for 72 h were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% <span class="html-italic">v</span>/<span class="html-italic">v</span>). The mean value ± SEM for three independent experiments is shown. The positive control was CA-4 (1.0 μM and 0.1 μM).</p>
Full article ">Figure 7 Cont.
<p>Preliminary cell viability data for (<b>A</b>) triazoles <b>22b–d</b>, <b>22f</b>, <b>22g</b> and imidazole <b>23d</b> and (<b>B</b>) triazoles <b>26a–e</b> and imidazoles <b>27a</b>, <b>27b</b>, <b>27e</b>, <b>27f</b>, <b>27h</b> and <b>27i</b> in HL-60 cells. Cell proliferation of HL-60 cells was determined with an alamarBlue assay (seeding density 2.5 × 10<sup>4</sup> cells/mL per well for 96-well plates). Compound concentrations of either 1 or 0.1 μM for 72 h were used to treat the cells (in triplicate) with control wells containing vehicle ethanol (1% <span class="html-italic">v</span>/<span class="html-italic">v</span>). The mean value ± SEM for three independent experiments is shown. The positive control was CA-4 (1.0 μM and 0.1 μM).</p>
Full article ">Figure 8
<p>Heatmap for compound <b>22b</b> across cell lines in the NCI-60 cell screen. Heatmap for the antiproliferative activity of compound <b>22b</b> (NCI 788807), across the cell lines in the NCI-60 screen, using three different values: (growth-inhibitory effect, GI<sub>50</sub>; drug concentration at which the response is reduced by half, IC<sub>50</sub>; cytostatic effect, TGI; cytotoxic effect, LC<sub>50</sub>; concentration in molar). Color key for GI<sub>50</sub> and IC<sub>50</sub>: green is more sensitive, and red is less sensitive.</p>
Full article ">Figure 9
<p>Effect of compounds <b>22a</b> (<b>A</b>) and <b>22b</b> (<b>B</b>) on the cell viability of non-tumorigenic MCF-10A human mammary epithelial cells at 24, 48, and 72 h. Cells were treated with the compounds <b>22a</b> and <b>22b</b> at concentrations of 10 μM, 1 μM, 0.5 μM, and 0.4 μM for 24, 48, or 72 h. (<b>C</b>) shows a comparison of the cell viability of MCF-10A cells and MCF-7 cells when treated with compound <b>22b</b> for 72 h at concentrations of 10 μM, 1 μM, and 0.5 μM. Cell viability was expressed as a percentage of vehicle control (ethanol 1% (<span class="html-italic">v</span>/<span class="html-italic">v</span>)) and was determined by an alamarBlue assay (average ± SEM of three independent experiments). Two-way ANOVA (Bonferroni post-test) was used to test for statistical significance (*, <span class="html-italic">p</span> &lt; 0.05; **, <span class="html-italic">p</span> &lt; 0.01; ***, <span class="html-italic">p</span> &lt; 0.001).</p>
Full article ">Figure 10
<p>Compound (<b>A</b>) <b>22b</b>, (<b>B</b>) phenstatin <b>19c</b> induced apoptosis in a time-dependent manner in MCF-7 cells. Cells were treated with either vehicle control [0.1% ethanol (<span class="html-italic">v</span>/<span class="html-italic">v</span>)] or compound <b>22b</b> or phenstatin <b>19c</b> (1 μM) for 24, 48, and 72 h). The data shown for the control vehicle and phenstatin are as we previously reported [<a href="#B65-pharmaceuticals-18-00118" class="html-bibr">65</a>]. Cells were fixed and stained with PI, followed by analysis using flow cytometry. Cell cycle analysis was performed on histograms of gated counts per DNA area (FL2-A). The number of cells with &lt;2 N (sub-G<sub>1</sub>), 2 N (G<sub>0</sub>G<sub>1</sub>), and 4 N (G<sub>2</sub>/M) DNA content was determined with CellQuest software, BD CellQuest Pro. Values are represented as the mean ± SEM for three separate experiments. Two-way ANOVA (Bonferroni post-test) was used to test for statistical significance (*, <span class="html-italic">p</span> &lt; 0.05; **, <span class="html-italic">p</span> &lt; 0.01; ***, <span class="html-italic">p</span> &lt; 0.001).</p>
Full article ">Figure 11
<p>Compound <b>22b</b> induced apoptosis in (<b>A</b>) MCF-7 breast cancer cells and (<b>B</b>) MDA-MB-231 breast cancer cells. MCF-7 breast cancer cells (<b>A</b>) and MDA-MB-23 breast cancer cells (<b>B</b>) were treated with <b>22b</b> (0.1, 0.5, and 1.0 μM) or phenstatin (<b>19c</b>) (0.1 μM and 0.5 μM) or control vehicle (0.1% ethanol (<span class="html-italic">v</span>/<span class="html-italic">v</span>)). The data shown for the control vehicle and phenstatin are as we previously reported [<a href="#B65-pharmaceuticals-18-00118" class="html-bibr">65</a>]. The apoptotic cell content was determined by staining with Annexin V-FITC and PI. In each panel, the lower right quadrant shows Annexin-positive cells in the early apoptotic stage and the upper right shows both Annexin/PI-positive cells in late apoptosis/necrosis. The lower left quadrant shows cells that are negative for both PI and Annexin V-FITC, and the upper left shows PI cells that are necrotic.</p>
Full article ">Figure 11 Cont.
<p>Compound <b>22b</b> induced apoptosis in (<b>A</b>) MCF-7 breast cancer cells and (<b>B</b>) MDA-MB-231 breast cancer cells. MCF-7 breast cancer cells (<b>A</b>) and MDA-MB-23 breast cancer cells (<b>B</b>) were treated with <b>22b</b> (0.1, 0.5, and 1.0 μM) or phenstatin (<b>19c</b>) (0.1 μM and 0.5 μM) or control vehicle (0.1% ethanol (<span class="html-italic">v</span>/<span class="html-italic">v</span>)). The data shown for the control vehicle and phenstatin are as we previously reported [<a href="#B65-pharmaceuticals-18-00118" class="html-bibr">65</a>]. The apoptotic cell content was determined by staining with Annexin V-FITC and PI. In each panel, the lower right quadrant shows Annexin-positive cells in the early apoptotic stage and the upper right shows both Annexin/PI-positive cells in late apoptosis/necrosis. The lower left quadrant shows cells that are negative for both PI and Annexin V-FITC, and the upper left shows PI cells that are necrotic.</p>
Full article ">Figure 12
<p>Compound <b>22b</b> depolymerizes the microtubule network of MCF-7 breast cancer cells. MCF-7 breast cancer cells were treated with (<b>A</b>) vehicle control [1% ethanol (<span class="html-italic">v</span>/<span class="html-italic">v</span>)], (<b>B</b>) paclitaxel (1 μM), (<b>C</b>) phenstatin (<b>19c</b>) (1 μM), or (<b>D</b>) compound <b>22b</b> (10 μM) for 16 h. Cells were preserved in ice-cold methanol and then stained with mouse monoclonal anti-α-tubulin–FITC–antibody (clone DM1A) (green), Alexa Fluor 488 dye, and counterstained with DAPI (blue). The micrograph images were obtained with Leica SP8 confocal microscopy utilizing Leica application suite X software. Representative confocal images of three separate experiments are shown. The scale bar indicates 25 μm.</p>
Full article ">Figure 13
<p>Inhibition of tubulin polymerization in vitro by compound <b>22b</b>. Tubulin polymerization assay for triazole compound <b>22b</b> at 10 μM and 30 μM concentration, together with control compounds paclitaxel (polymeriser) (10 μM) and phenstatin (depolymeriser) <b>19c</b> (10 μM). DMSO (1% <span class="html-italic">v</span>/<span class="html-italic">v</span>) was used in the vehicle control. Purified bovine tubulin and guanosine-5′-triphosphate (GTP) were initially mixed at 4 °C in a 96-well plate; the polymerization reaction was then initiated by warming the solution from 4 to 37 °C. The progress of the tubulin polymerization reaction at 37 °C was monitored at 340 nm in a Spectramax 340PC spectrophotometer at 30 s intervals for 60 min. Fold inhibition of tubulin polymerization can be calculated from the Vmax value for each reaction. The data shown for the control vehicle and phenstatin are as we previously reported [<a href="#B65-pharmaceuticals-18-00118" class="html-bibr">65</a>].</p>
Full article ">Figure 14
<p>Docking of compounds <b>22b</b> in the colchicine binding site of tubulin. Overlay of the X-ray structure of tubulin co-crystallized with DAMA-colchicine (PDB entry 1SA0, [<a href="#B116-pharmaceuticals-18-00118" class="html-bibr">116</a>]) on the best-ranked docked poses of <span class="html-italic">(S)-</span><b>22b</b> and <span class="html-italic">(R)-</span><b>22b</b>. Ligands are rendered as tubes and amino acids as lines. Tubulin amino acids and DAMA-colchicine are colored by atom type; the novel compounds are colored green. The atoms are colored by element type, carbon = grey, hydrogen = white, oxygen = red, nitrogen = blue, sulfur = yellow. Key amino acid residues are labeled, and multiple residues are hidden to enable a clearer view.</p>
Full article ">Scheme 1
<p>Synthesis of (<span class="html-italic">E</span>)-1-(3-aryl)-1-(3,4,5-trimethoxyphenyl)allyl)-1<span class="html-italic">H</span>-1,2,4-triazoles <b>22a–g</b> (Series 1) and (<span class="html-italic">E</span>)-1-(3-(aryl)-1-(3,4,5-trimethoxyphenyl)allyl)-1<span class="html-italic">H</span>-imidazoles <b>23a–e</b> (Series 2): reagents and conditions (<b>a</b>): KOH, methanol, 20 °C (27–87%) (<b>b</b>): NaBH<sub>4</sub>, MeOH/THF, 1 h, 20 °C (85–100%); (<b>c</b>) <span class="html-italic">p</span>-TSA, 1,2,4-triazole, toluene, microwave, 4 h (30–76%); (<b>d</b>) CDI, dry ACN, reflux, 1 h (26–45%).</p>
Full article ">Scheme 2
<p>Synthesis of 1-(3-aryl-4,5,6-trimethoxy-2,3-dihydro-1<span class="html-italic">H</span>-inden-1-yl)-1<span class="html-italic">H</span>-1,2,4-triazoles <b>26a–e</b> (Series 3) and 1-(3-aryl-4,5,6-trimethoxy-2,3-dihydro-1<span class="html-italic">H</span>-inden-1-yl)-1<span class="html-italic">H</span>-imidazoles <b>27a–i</b> (Series 4). Scheme reagents and conditions: (<b>a</b>) TFA, 120 °C, 10 min microwave (44–96%); (<b>b</b>) NaBH<sub>4</sub>, MeOH/THF (1:1), 0–20 °C (43–100%); (<b>c</b>) <span class="html-italic">p</span>-TSA, 1,2,4-triazole, toluene, microwave, 4 h (30–54%); (<b>d</b>) CDI, dry acetonitrile, reflux, 3 h (4–70%).</p>
Full article ">Scheme 3
<p>Synthesis of 1-((1<span class="html-italic">E</span>,4<span class="html-italic">E</span>)-1,5-bis(3,4,5-trimethoxyphenyl)penta-1,4-dien-3-yl)-1<span class="html-italic">H</span>-imidazole <b>30</b>. Reagents and conditions: (<b>a</b>): Acetone, EtOH, NaOH (10%, aqueous), 30 min, 20 °C (68%); (<b>b</b>): NaBH<sub>4</sub>, MeOH/THF, 1 h, 20 °C (92%); (<b>c</b>) CDI, dry ACN, 3 h, reflux (27%).</p>
Full article ">Scheme 4
<p>Synthesis of (<span class="html-italic">E</span>)-3-(anthracen-9-yl)-1-(4-iodophenyl)allyl)-1<span class="html-italic">H</span>-imidazole (<b>33a</b>) and (<span class="html-italic">E</span>)-3-(anthracen-9-yl)-1-(4-pyridyl))allyl)-1<span class="html-italic">H</span>-imidazole (<b>33b</b>): reagents and conditions: (<b>a</b>): KOH, methanol, 20 °C (49–82%) (<b>b</b>): NaBH<sub>4</sub>, MeOH/THF, 1 h, 20 °C (78–98%); (<b>c</b>) CDI, dry ACN, reflux, 1 h (5–58%).</p>
Full article ">
21 pages, 5551 KiB  
Article
Effects of Chinese Herbal Medicines on Growth Performance, Antioxidant Capacity, and Liver and Intestinal Health of Hybrid Snakehead (Channa maculata ♀ × Channa. argus ♂)
by Jiamin Kang, Shuzhan Fei, Junhao Zhang, Haiyang Liu, Qing Luo, Mi Ou, Langjun Cui, Tao Li and Jian Zhao
Fishes 2025, 10(1), 33; https://doi.org/10.3390/fishes10010033 - 16 Jan 2025
Viewed by 527
Abstract
Chinese herbal medicines have become a new green feed additive in the aquaculture industry. The aim of this study is to investigate the effects of traditional Chinese herbal medicines (Isatidis radix, Forsythia suspensa, and Schisandra chinensis) on the growth [...] Read more.
Chinese herbal medicines have become a new green feed additive in the aquaculture industry. The aim of this study is to investigate the effects of traditional Chinese herbal medicines (Isatidis radix, Forsythia suspensa, and Schisandra chinensis) on the growth performance, antioxidant capacity, and intestinal microbiota of hybrid snakehead (Channa maculata× Channa argus ♂). A total of 600 fish (mean weight: 15.85 ± 0.15 g) were randomly assigned to five groups, including the control group (CG), I. radix extract group (IRE), F. suspensa extract group (FSE), S. chinensis extract group (SCE), and the Chinese herbal medicine mixture group (CHMM; a mixture of extracts of I. radix, F. suspensa, and S. chinensis at the ratio of 1:1:1) for 6 weeks. The results show that the IRE-supplemented diet improved the survival rate (SR), feed efficiency ratio (FE), and condition factor (CF) compared to others. Compared to the control group, the activity of superoxide dismutase (SOD) in plasma and intestine was significantly increased in the FSE and CHMM groups, whereas the content of malondialdehyde (MDA) in plasma and liver was significantly reduced in the SCE group. A 16s rRNA analysis indicates that dietary supplementation with FSE significantly promoted the proliferation of Fusobacteriota, while IRE supplementation increased the alpha diversity of intestinal bacteria. In conclusion, the addition of I. radix to the diet of hybrid snakehead improves growth, antioxidant capacity, and liver and intestine health, and modulates the intestinal microbiota of snakehead positively. Full article
(This article belongs to the Special Issue Impacts of Dietary Supplements on Fish Growth and Health)
Show Figures

Figure 1

Figure 1
<p>(<b>A</b>) Effects of dietary supplementation with CHM extracts on liver histology of hybrid snakehead. (<b>B</b>) Relative contents of liver lipid droplets in each experimental group. Values are expressed as means ± S.E. Values not sharing same letters are significantly different (<span class="html-italic">p</span> &lt; 0.05). N and black arrow: nucleus; V and red arrow: fat vacuoles; red circles indicate nuclei offset by cell vacuolization; black circles indicate the accumulation of fat droplets.</p>
Full article ">Figure 2
<p>Effects of dietary supplementation with CHM extracts on intestinal histology of hybrid snakehead (HE). The MT indicates the muscular thickness, the VH indicates the villi heights, the VW indicates the villi width, and the GC indicates the goblet cells. The circles represent intestinal mucous membrane shedding. The triangles represent intestinal villi fall-off. The pentagram represents intestinal villus adhesion.</p>
Full article ">Figure 3
<p>The intestinal microscopic structure parameters of hybrid snakehead. (<b>A</b>) The intestinal villi heights of hybrid snakehead; (<b>B</b>) The intestinal villi width of hybrid snakehead; (<b>C</b>) The intestinal muscular thickness of hybrid snakehead; (<b>D</b>) The intestinal goblet cells of hybrid snakehead. Values are expressed as means ± S.E. Values not sharing same letters are significantly different (<span class="html-italic">p</span> &lt; 0.05).</p>
Full article ">Figure 4
<p>Effects of dietary supplementation with CHM extracts on antioxidant performance in plasma (<b>A</b>–<b>C</b>), liver (<b>D</b>–<b>F</b>), and intestine (<b>G</b>–<b>I</b>) of hybrid snakehead. Values are expressed as means ± S.E. (n = 6), and values not sharing same letters are significantly different (<span class="html-italic">p</span> &lt; 0.05).</p>
Full article ">Figure 5
<p>Effect of dietary supplementation with CHM on the relative expression of immune-related genes and antioxidant genes in the liver (<b>A</b>) and (<b>B</b>) intestine of hybrid snakehead. Values are expressed as means ± S.E., and values not sharing same letters are significantly different (<span class="html-italic">p</span> &lt; 0.05).</p>
Full article ">Figure 6
<p>PCoA analysis of intestinal microflora in hybrid snakehead at the OTU level. (<b>A</b>) Venn diagram; (<b>B</b>) Venn diagram showing the OTUs between different groups and the OTUs shared between groups in the intestinal microbiota in hybrid snakehead.</p>
Full article ">Figure 7
<p>The relative abundance of intestine microbiota composition in hybrid snakehead at the (<b>A</b>) phylum level and (<b>B</b>) genus level.</p>
Full article ">Figure 8
<p>Pearson correlation between intestinal microbial community and growth indexes, inflammatory genes, and antioxidant indexes. (<b>A</b>) The relationship between the abundance of intestinal contents at phylum level with inflammatory genes, growth performance, and antioxidant indexes. (<b>B</b>) The relationship between the abundance of intestinal contents at genus level with inflammatory genes, growth performance, and antioxidant indexes. *: values differ significantly (<span class="html-italic">p</span> &lt; 0.05); **: values differ extremely significantly (<span class="html-italic">p</span> &lt; 0.01).</p>
Full article ">
24 pages, 2585 KiB  
Article
Evaluating AI-Driven Mental Health Solutions: A Hybrid Fuzzy Multi-Criteria Decision-Making Approach
by Yewande Ojo, Olasumbo Ayodeji Makinde, Oluwabukunmi Victor Babatunde, Gbotemi Babatunde and Subomi Okeowo
AI 2025, 6(1), 14; https://doi.org/10.3390/ai6010014 - 16 Jan 2025
Viewed by 469
Abstract
Background: AI-driven mental health solutions offer transformative potential for improving mental healthcare outcomes, but identifying the most effective approaches remains a challenge. This study addresses this gap by evaluating and prioritizing AI-driven mental health alternatives based on key criteria, including feasibility of implementation, [...] Read more.
Background: AI-driven mental health solutions offer transformative potential for improving mental healthcare outcomes, but identifying the most effective approaches remains a challenge. This study addresses this gap by evaluating and prioritizing AI-driven mental health alternatives based on key criteria, including feasibility of implementation, cost-effectiveness, scalability, ethical compliance, user satisfaction, and impact on clinical outcomes. Methods: A fuzzy multi-criteria decision-making (MCDM) model, consisting of fuzzy TOPSIS and fuzzy ARAS, was employed to rank the alternatives, while a hybridization of the two methods was used to address discrepancies between the methods, each emphasizing distinct evaluative aspect. Results: Fuzzy TOPSIS, focusing on closeness to the ideal solution, ranked personalization of care (A5) as the top alternative with a closeness coefficient of 0.50, followed by user engagement (A2) at 0.45. Fuzzy ARAS, which evaluates cumulative performance, also ranked A5 the highest, with an overall performance rating of Si = 0.90 and utility degree Qi = 0.92. Combining both methods provided a balanced assessment, with A5 retaining its top position due to high scores in user satisfaction and clinical outcomes. Conclusions: This result underscores the importance of personalization and engagement in optimizing AI-driven mental health solutions, suggesting that tailored, user-focused approaches are pivotal for maximizing treatment success and user adherence. Full article
(This article belongs to the Section Medical & Healthcare AI)
Show Figures

Figure 1

Figure 1
<p>Methodology of the study.</p>
Full article ">Figure 2
<p>Triangular fuzzy quantity.</p>
Full article ">Figure 3
<p>Triangular 10-point linguistic scale used in this study [<a href="#B26-ai-06-00014" class="html-bibr">26</a>].</p>
Full article ">Figure 4
<p>The hierarchical structure of the problems considered in this study.</p>
Full article ">Figure 5
<p>Ethical perspectives considered in this study.</p>
Full article ">Figure 6
<p>Closeness coefficient, utility degree, and hybrid score for the alternatives.</p>
Full article ">Figure 7
<p>Rank for TOPSIS, ARAS, and hybrid rank methods.</p>
Full article ">
12 pages, 2994 KiB  
Article
Molecular Genetic Assessment Aids in Clarifying Phylogenetic Status of Iranian Kerman Wild Sheep
by Arsen V. Dotsev, Mohammad Hossein Moradi, Tatiana E. Deniskova, Ali Esmailizadeh, Neckruz F. Bakoev, Olga A. Koshkina, Darren K. Griffin, Michael N. Romanov and Natalia A. Zinovieva
Animals 2025, 15(2), 238; https://doi.org/10.3390/ani15020238 - 16 Jan 2025
Viewed by 218
Abstract
Two species of wild sheep inhabit Iran: Asiatic mouflon (Ovis gmelini) and urial (O. vignei). Phylogenetic relationships between populations distributed in this country are complex and still remain unclear. This study aimed to clarify, by genetic assessment, the phylogenetic [...] Read more.
Two species of wild sheep inhabit Iran: Asiatic mouflon (Ovis gmelini) and urial (O. vignei). Phylogenetic relationships between populations distributed in this country are complex and still remain unclear. This study aimed to clarify, by genetic assessment, the phylogenetic status of Kerman wild sheep, considered to be a hybrid of the two species. For this purpose, we created a dataset that included specimens of O. gmelini, O. vignei, and Kerman sheep. We applied genome-wide SNP genotyping technology to analyze population structure and genetic diversity of these groups. Using Neighbor-Net and PCA plots, it was demonstrated that Kerman sheep were differentiated from other groups and occupy an intermediate position between O. gmelini and O. vignei. Using Admixture analysis, two ancestral components were identified in this population; however, admixed ancestry was not confirmed by f3 statistics. Genetic diversity in Kerman wild sheep was significantly higher than in any group of O. vignei, but lower than in O. gmelini. Additionally, we examined complete mitochondrial genomes and it was demonstrated that the matrilineal ancestor of Kerman sheep belonged to O. vignei. Our results lead to the conclusion that Kerman wild sheep can be recognized as a separate subspecies of O. vignei. Full article
(This article belongs to the Special Issue Genetics and Breeding in Ruminants)
Show Figures

Figure 1

Figure 1
<p>Kerman wild sheep in their natural habitat. (<b>a</b>) One of the specimens (WU950/PQ652216) examined in this study. Courtesy: A documentary screenshot by Sergey Mazurkevich. (<b>b</b>) A herd of wild sheep in Khabr National Park in Kerman province, Southern Iran. Credit: <a href="https://commons.wikimedia.org/wiki/File:Khabr_national_park.jpg" target="_blank">https://commons.wikimedia.org/wiki/File:Khabr_national_park.jpg</a>, accessed on 4 December 2024, by Sina.najmadini (CC-BY-SA-4.0).</p>
Full article ">Figure 2
<p>The sampling sites of the specimens examined in this study. Abbreviations: <span class="html-italic">O.</span>, <span class="html-italic">Ovis</span>; <span class="html-italic">O. v.</span>, <span class="html-italic">Ovis vignei</span>; UZB, Uzbekistan; TJK, Tajikistan.</p>
Full article ">Figure 3
<p>Principal component analysis-based plot (<b>A</b>), an individual Neighbor-Net tree (<b>B</b>), and Admixture analysis-assisted plot (<b>C</b>) revealing population structure in <span class="html-italic">O. gmelini</span> and <span class="html-italic">O. vignei</span>. This figure includes the Asiatic mouflon (<span class="html-italic">O. gmelini</span>), three subspecies of the urial, i.e., Transcaspian (<span class="html-italic">O. v. arkal</span>), Afghan (<span class="html-italic">O. v. cycloceros</span>), and Blanford’s (<span class="html-italic">O. v. blanfordi</span>), from Iran as well as three other subspecies of the urial, including Punjab (<span class="html-italic">O. v. punjabiensis</span>, Pakistan) and Bukhara (<span class="html-italic">O. v. bocharensis</span>, from Tajikistan and Uzbekistan). Abbreviations: UZB, Uzbekistan; TJK, Tajikistan.</p>
Full article ">Figure 4
<p>Neighbor-Net configuration demonstrating phylogenetic relationships of <span class="html-italic">O. gmelini</span> and <span class="html-italic">O. vignei</span> populations based on pairwise <span class="html-italic">F</span><sub>ST</sub> genetic distances. Abbreviations: UZB, Uzbekistan; TJK, Tajikistan.</p>
Full article ">Figure 5
<p>Multilocus heterozygosity (MLH) in Kerman wild sheep as compared to groups of <span class="html-italic">O. gmelini</span> and <span class="html-italic">O. vignei</span>. Abbreviations: UZB, Uzbekistan; TJK, Tajikistan.</p>
Full article ">Figure 6
<p>Rooted Bayesian phylogenetic tree based on mitogenomes. All posterior probabilities were equal to 1.</p>
Full article ">
12 pages, 2987 KiB  
Article
Analysis of Refractive Index Sensing Properties of a Hybrid Hollow Cylindrical Tetramer Array
by Meng Wang, Paerhatijiang Tuersun, Aibibula Abudula, Lan Jiang and Dibo Xu
Nanomaterials 2025, 15(2), 118; https://doi.org/10.3390/nano15020118 - 15 Jan 2025
Viewed by 312
Abstract
In recent years, metal surface plasmon resonance sensors and dielectric guided-mode resonance sensors have attracted the attention of researchers. Metal sensors are sensitive to environmental disturbances but have high optical losses, while dielectric sensors have low losses but limited sensitivity. To overcome these [...] Read more.
In recent years, metal surface plasmon resonance sensors and dielectric guided-mode resonance sensors have attracted the attention of researchers. Metal sensors are sensitive to environmental disturbances but have high optical losses, while dielectric sensors have low losses but limited sensitivity. To overcome these limitations, hybrid resonance sensors that combine the advantages of metal and dielectric were proposed to achieve a high sensitivity and a high Q factor at the same time. In this paper, a hybrid hollow cylindrical tetramer array was designed, and the effects of the hole radius, external radius, height, period, incidence angle, and polarization angle of the hollow cylindrical tetramer array on the refractive index sensing properties were quantitatively analyzed using the finite difference time domain method. It is found that the position of the resonance peaks can be freely tuned in the visible and near-infrared regions, and a sensitivity of up to 542.8 nm/RIU can be achieved, with a Q factor of 1495.1 and a figure of merit of 1103.3 RIU−1. The hybrid metal–dielectric nanostructured array provides a possibility for the realization of high-performance sensing devices. Full article
(This article belongs to the Special Issue Modeling, Simulation and Optimization of Nanomaterials)
Show Figures

Figure 1

Figure 1
<p>The unit structure, (<b>a</b>) Three-dimensional diagram and (<b>b</b>) <span class="html-italic">xoy</span> plane diagram of the hybrid hollow cylindrical tetrameric array.</p>
Full article ">Figure 2
<p>The reflectance spectrum of the hybrid hollow cylindrical tetramer array varies with (<b>a</b>) hole radius <span class="html-italic">r</span> and (<b>b</b>) environmental refractive index <span class="html-italic">n</span> and their corresponding values of (<b>c</b>) <span class="html-italic">S</span><sub>bulk</sub>, (<b>d</b>) <span class="html-italic">Q</span> factor, and (<b>e</b>) <span class="html-italic">FOM</span>. In the simulation, the external radius <span class="html-italic">R</span><sub>1</sub> of the large hollow cylinder is 140 nm, the external radius <span class="html-italic">R</span><sub>2</sub> of the small hollow cylinder is 100 nm, the period <span class="html-italic">P</span> is 800 nm, the height <span class="html-italic">h</span> of Si<sub>3</sub>N<sub>4</sub> is 225 nm, and the thickness <span class="html-italic">t</span> of the Au layer is 100 nm.</p>
Full article ">Figure 3
<p>Electric field distributions in the (<b>a</b>–<b>c</b>) <span class="html-italic">xoy</span> plane and (<b>d</b>–<b>f</b>) <span class="html-italic">xoz</span> plane at the resonance wavelengths of 679.0 nm, 736.3 nm, and 868.9 nm, respectively.</p>
Full article ">Figure 4
<p>The variation in (<b>a</b>) reflectance spectrum with the external radius <span class="html-italic">R</span><sub>2</sub> of the small hollow cylinder and the corresponding (<b>b</b>) <span class="html-italic">S</span><sub>bulk</sub>, (<b>c</b>) <span class="html-italic">Q</span> factor, and (<b>d</b>) <span class="html-italic">FOM</span> of the hybrid hollow cylindrical tetramer array. In the simulation, the external radius <span class="html-italic">R</span><sub>1</sub> of the large hollow cylinder is 140 nm, the hole radius <span class="html-italic">r</span> of the hollow cylinder is 40 nm, the period <span class="html-italic">P</span> is 800 nm, the height <span class="html-italic">h</span> of Si<sub>3</sub>N<sub>4</sub> is 225 nm, the thickness <span class="html-italic">t</span> of the Au layer is 100 nm, and the environmental refractive index <span class="html-italic">n</span> is 1.3.</p>
Full article ">Figure 5
<p>The variation in (<b>a</b>) reflectance spectrum with the cylindrical height <span class="html-italic">h</span> and the corresponding (<b>b</b>) <span class="html-italic">S</span><sub>bulk</sub>, (<b>c</b>) <span class="html-italic">Q</span> factor, and (<b>d</b>) <span class="html-italic">FOM</span> of the hybrid hollow cylindrical tetramer array. In the simulation, the external radius <span class="html-italic">R</span><sub>1</sub> of the large hollow cylinder is 140 nm, the external radius <span class="html-italic">R</span><sub>2</sub> of the small hollow cylinder is 100 nm, the hole radius <span class="html-italic">r</span> of the hollow cylinder is 40 nm, the period <span class="html-italic">P</span> is 800 nm, the thickness <span class="html-italic">t</span> of the Au layer is 100 nm, and the environmental refractive index <span class="html-italic">n</span> is 1.3.</p>
Full article ">Figure 6
<p>The variation in (<b>a</b>) reflectance spectrum with the period <span class="html-italic">P</span> and the corresponding (<b>b</b>) <span class="html-italic">S</span><sub>bulk</sub>, (<b>c</b>) <span class="html-italic">Q</span> factor, and (<b>d</b>) <span class="html-italic">FOM</span> of the hybrid hollow cylindrical tetramer array. In the simulation, the external radius <span class="html-italic">R</span><sub>1</sub> of the large hollow cylinder is 140 nm, the external radius <span class="html-italic">R</span><sub>2</sub> of the small hollow cylinder is 100 nm, the hole radius <span class="html-italic">r</span> of the hollow cylinder is 40 nm, the height <span class="html-italic">h</span> of Si<sub>3</sub>N<sub>4</sub> is 225 nm, the thickness <span class="html-italic">t</span> of the Au layer is 100 nm, and the environmental refractive index <span class="html-italic">n</span> is 1.3.</p>
Full article ">Figure 7
<p>The variation in reflectance spectrum of the hybrid hollow cylindrical tetramer array with (<b>a</b>) incidence angle <span class="html-italic">θ</span> and (<b>b</b>) polarization angle of the incident light.</p>
Full article ">
34 pages, 1229 KiB  
Review
A Review of CNN Applications in Smart Agriculture Using Multimodal Data
by Mohammad El Sakka, Mihai Ivanovici, Lotfi Chaari and Josiane Mothe
Sensors 2025, 25(2), 472; https://doi.org/10.3390/s25020472 - 15 Jan 2025
Viewed by 517
Abstract
This review explores the applications of Convolutional Neural Networks (CNNs) in smart agriculture, highlighting recent advancements across various applications including weed detection, disease detection, crop classification, water management, and yield prediction. Based on a comprehensive analysis of more than 115 recent studies, coupled [...] Read more.
This review explores the applications of Convolutional Neural Networks (CNNs) in smart agriculture, highlighting recent advancements across various applications including weed detection, disease detection, crop classification, water management, and yield prediction. Based on a comprehensive analysis of more than 115 recent studies, coupled with a bibliometric study of the broader literature, this paper contextualizes the use of CNNs within Agriculture 5.0, where technological integration optimizes agricultural efficiency. Key approaches analyzed involve image classification, image segmentation, regression, and object detection methods that use diverse data types ranging from RGB and multispectral images to radar and thermal data. By processing UAV and satellite data with CNNs, real-time and large-scale crop monitoring can be achieved, supporting advanced farm management. A comparative analysis shows how CNNs perform with respect to other techniques that involve traditional machine learning and recent deep learning models in image processing, particularly when applied to high-dimensional or temporal data. Future directions point toward integrating IoT and cloud platforms for real-time data processing and leveraging large language models for regulatory insights. Potential research advancements emphasize improving increased data accessibility and hybrid modeling to meet the agricultural demands of climate variability and food security, positioning CNNs as pivotal tools in sustainable agricultural practices. A related repository that contains the reviewed articles along with their publication links is made available. Full article
(This article belongs to the Special Issue Feature Review Papers in Intelligent Sensors)
Show Figures

Figure 1

Figure 1
<p>The evolution of the number of papers published every year on the Web of Science related to Convolutional Neural Networks, deep learning, or machine learning in agriculture.</p>
Full article ">Figure 2
<p>Authors’ keywords from all documents retrieved through the search query on the Web of Science, visualized using the thematic evolution function of the bibliometrix R package (version 4.3.0).</p>
Full article ">Figure 3
<p>Authors’ keywords from all documents retrieved through the search query on the Web of Science, after excluding terms related to the search query, visualized using the thematic evolution function of the bibliometrix R package (version 4.3.0).</p>
Full article ">Figure 4
<p>General workflow of smart agriculture. From identifying agricultural needs to deploying solutions, both data and models play a crucial role in developing effective solutions.</p>
Full article ">Figure 5
<p>Data sources used in various fields in smart agriculture. This Sankey diagram illustrates the flow of data from various sources to different fields in agriculture. This diagram was created based on a review of the literature. Research papers were analyzed to identify data sources and the respective agricultural fields to which they were applied. Specifically, the terms on the left correspond to distinct data sources that were identified, while the terms on the right represent the different agricultural fields in which they were employed.</p>
Full article ">Figure 6
<p>Data types used in various fields in smart agriculture. This Sankey diagram illustrates the various data types used in smart agriculture and their distribution across different agricultural fields. This diagram was created based on a review of the literature. Research papers were analyzed to identify data types and the respective agricultural fields to which they were applied. Specifically, the terms on the left correspond to distinct data types that were identified, while the terms on the right represent the different agricultural fields in which they were employed.</p>
Full article ">
Back to TopTop