Search Results (355)

This paper presents an experimental study on the elastic support in a discrete rail fastening system used in a ballastless tram track structure. The study focuses on the elastic support of the anchor element, specifically the Pm49 baseplate. These elements significantly influence environmental pollution along tram routes, such as vibration (at low frequencies) or noise (at high frequencies), as well as static and dynamic rail deflections. The authors outline a methodology for identifying the static and dynamic characteristics of the discrete elastic support in laboratory conditions. The procedure follows the European standard EN 13146-9 for track category A (tramway), as classified according to the European standard EN 13481-5. The study analyzes how the thickness and density of the tested materials affect stiffness. Additionally, it examines the correlation between parameters identified easily on-site (thickness, Shore hardness and density) and laboratory-determined parameters (static and dynamic stiffness), which are costly and time-consuming to measure. The research confirms that prototype prefabricated vibration isolation baseplate pads made of styrene butadiene rubber (SBR) granules, recycled from end-of-life car tires, can achieve equivalent basic static and dynamic parameters, compared to underlays made of two-component polyurethane (PU) resin. This aligns with the strategy of promoting sustainable materials in construction. The innovative and prefabricated SBR rubber baseplate pads can also be used in repair and maintenance works (regardless of weather conditions), as they enable the quick launch of tram traffic. The results of the research included in this article can be used by other scientists, recycled rubber producers, tram track designers or construction site engineers. Full article

Gerbera (Gerbera hybrida) is a popular cut flower on the market, so extending its vase life (VL) is an important goal in the horticultural industry. The aim of this study was to improve the freshness of gerbera cut flowers through the optimal solution (OS) and to analyze its preservation mechanism. We used chitosan (COS), calcium chloride (CaCl₂), and citric acid (CA) as the main ingredients of the vase solution and determined the OS ratio of 104 mg/L of COS, 92 mg/L of CA, and 93 mg/L of CaCl₂ using the Box–Behnken design-response surface method (BBD-RSM). Gerbera preservation results showed that the VL of the OS was 14.5 days, which was significantly longer than that of flowers maintained in the Basic Vase Solution (BVS) and the Commercial Formulation (CF) and was highly consistent with the theoretical VL of 14.57 d. Transcriptome analysis indicated that the OS might extend VL by regulating phytohormone signaling pathways, such as cytokinin and salicylic acid signaling. The qRT-PCR analysis of key candidate genes supported these findings, with significant upregulation observed in genes related to cytokinin synthesis (e.g., GhIPT1 and GhIPT9), salicylic acid signaling related to pathogen defense (e.g., GhTGA1, GhTGA4, GhNPR1, and GhRBOHA), and plant wax synthesis and stress response (e.g., GhKCS5, GhCUT1, and GhKCS6). Further, transcriptome GO-enrichment and physiological analysis showed that the OS might extend VL of Gerbera cut flowers by scavenging reactive oxygen species, including by activating the expression of genes related to oxidoreductase activity and the activities of antioxidant-system-related enzymes catalase (CAT), peroxidase (POD), ascorbate peroxidase (APX), and superoxide dismutase (SOD), while decreasing the malondialdehyde (MDA) content. These results provide valuable insights into the mechanisms underlying the extended VL of gerbera cut flowers and offer a foundation for developing more effective preservation techniques. Full article

Suicidal ideation and behavior are critical psychological crises among children and adolescents, posing significant concerns for their mental health and safety. This cross-sectional study investigated the factors and underlying psychological mechanisms of suicidal ideation in adolescents. A total of 6474 middle school students from Sichuan and Hebei provinces, China, participated in the study. Data were collected using the Self-Assessment of Suicidal Ideation Scale, the Parental Psychological Control Scale, the Meaning in Life Scale, and the Basic Psychological Needs Scale. Statistical analyses, including mediation and chain mediation analyses, were conducted to examine the relationships between parental psychological control, basic psychological needs, meaning in life, and suicidal ideation. The results revealed the following: (1) Parental psychological control positively predicted suicidal ideation in middle school students; (2) basic psychological needs mediated the relationship between parental psychological control and suicidal ideation; (3) meaning in life mediated the relationship between parental psychological control and suicidal ideation; (4) basic psychological needs and meaning in life together played a chain-mediating role in this relationship. These findings highlight the importance of addressing parental psychological control and fostering a supportive family environment to meet adolescents’ psychological needs, enhance their sense of life meaning, and reduce suicidal ideation. Insights from this study provide valuable guidance for prevention and intervention strategies aimed at safeguarding adolescents’ mental health and well-being. Full article

The alarming rise in environmental pollution, depletion of global resources, and increasing health consciousness have placed significant pressure on the development of eco-friendly, sustainable materials. Consequently, green, environmentally friendly materials made from biobased and/or biodegradable sources are gaining recognition and political support as sustainable alternatives to petroleum-based, non-biodegradable materials. Bio-based packaging materials, in particular, are widely used across all industrial sectors, with a growing demand for solutions that preserve food quality and extend shelf life. Within this context, the concept of “active packaging” (AP) is attracting considerable interest. While the traditional view of packaging materials is that they should be basically inert, active packaging involves intentional interactions with the packaged product or surrounding atmosphere, providing enhanced protection against degradation caused by human actions and environmental factors. This work aims to highlight the significant impact of biocomposites in the active packaging sector, driven by the synergistic integration of nanofillers and active agents, while providing an in-depth analysis of the key mechanisms and strategies underlying their functionality. Particular emphasis is placed on poly(lactic acid)(PLA), presenting a comprehensive review of innovative approaches to enhance the performance of PLA-based packaging, with a focus on improving antioxidant and antimicrobial properties to meet the demands of sustainable and efficient packaging solutions. Full article

Grape pomace (GP), a byproduct of winemaking, has gained significant attention as a sustainable and functional ingredient with applications in the food and nutraceutical industries. This review examines the potential of GP in meat products and analogs, functional foods, and nutraceuticals, highlighting its composition, health benefits, and role in enhancing nutritional and functional properties. Rich in dietary fiber, polyphenols, essential fatty acids, and bioactive compounds, GP exhibits antioxidant, anti-inflammatory, and gut health-promoting effects, making it suitable for various food applications. Its incorporation into meat products, such as sausages and patties, improves texture, enhances shelf life, and increases nutritional value while reducing the environmental footprint. GP is also effective in functional foods such as baked goods, dairy and plant-based yoghurts, smoothies, and snack bars, where it can enrich fiber and polyphenol content, aid in satiety, and provide health benefits beyond basic nutrition. The challenge is how to maintain the sensory properties characteristic of conventional, unmodified products. In nutraceuticals, GP’s polyphenolic compounds and dietary fiber support antioxidant, anti-inflammatory, and metabolic health functions, with applications as antioxidant supplements, gut health boosters, weight management aids, and cardiovascular health supplements. Despite challenges such as taste modification and optimizing bioavailability, GP’s versatility and sustainability highlight its value in developing innovative, health-oriented products. This review emphasizes the promise of GP as a valuable ingredient in functional foods and nutraceutical formulations, contributing to health, sustainability, and resource efficiency. Full article

Background/Objectives: Basic psychological needs are essential for fostering motivation, self-regulated behaviors, and overall well-being. For cancer survivors, fulfilling these needs is crucial for coping with the various challenges of survivorship and for enhancing psychosocial health. This study aimed to assess the validity and reliability of the Korean version of the Basic Psychological Needs Satisfaction and Frustration Scale (K-BPNSFS) in a cancer survivor population. Methods: A cross-sectional design was employed, involving 367 community-dwelling cancer survivors. Construct validity was assessed using confirmatory factor analysis with multiple fit indices, while convergent validity was examined through Pearson’s correlation coefficients. Reliability was evaluated using internal consistency, inter-item correlations, and item-total correlations. Results: The findings confirmed a robust six-factor structure of the K-BPNSFS, which includes satisfaction and frustration dimensions corresponding to autonomy, relatedness, and competence needs. Convergent validity was supported by significant correlations with relevant constructs, aligning with the scale’s theoretical underpinnings. Reliability analysis demonstrated high internal consistency across all dimensions, with strong Cronbach’s alpha values and substantial item-total and inter-item correlations. Conclusions: This study establishes the K-BPNSFS as a valid, reliable, and culturally relevant instrument for assessing the basic psychological needs of Korean cancer survivors. Application of this scale provides critical insights into the unique psychological needs of this population, supporting the development of targeted healthcare strategies to enhance intrinsic motivation, self-care, and overall quality of life. Full article

In the context of climate change, there is a growing need for accurate, real-time data on water quality in river waterways. This results in the development of advanced monitoring systems. This article presents a remote water quality monitoring system designed specifically for use in inland waterways, the basic elements of which are placed in a buoy with an IoT unit. The proposed system uses a network of sensors strategically placed along the waterway to continuously measure critical parameters: temperature, pH, dissolved oxygen, and conductivity. Various compatibility, efficiency, and ease-of-use tests have been conducted to verify each aspect of the monitoring system. It has been shown that the sensors operate within the intended accuracy ranges. The central unit equipped with a GSM (Global System for Mobile Communications) module can wirelessly transmit data to a main server, enabling remote access and analysis via a user-friendly interface of the developed application. The paper details the technical architecture of the system, the integration of GSM technology to ensure reliable data transmission, and the results of the monitoring studies of the proposed parameters. The remote monitoring system offers significant benefits in terms of early detection of pollution events, ensuring the safety of aquatic life, and supporting sustainable navigation practices. The research results highlight the potential of GSM-based remote monitoring systems to revolutionize water quality management in waterways in various regions. Full article

When a refugee is accepted for resettlement in the United States, they are assigned to a refugee resettlement office that is responsible for providing for all the initial basic needs that a refugee family may need, including finding and furnishing appropriate housing. Finding and procuring housing is the largest challenge to successful integration that resettlement organizations face. Housing has always been a concern in refugee resettlement because there is no coordinated body at the federal level that provides guidance or housing assistance. Nor is there a federal law to ensure that living spaces are set aside for those who have been accepted for resettlement. Without federal support, refugee resettlement, although ultimately successful, can be disorganized and decentralized leading to a situation that is volatile and open to the capriciousness of shifting political leadership. Drawing upon qualitative research conducted with one refugee resettlement organization, which I call Refugee Resettlement Affiliate Office (RRAO), to elucidate the ongoing challenges to housing integration for those refugees resettled in the United States, I assert that a federal solution is needed in order to ensure the smooth integration into life in the US for resettled refugees. This article articulates the challenges to housing as expressed by those working in refugee resettlement and discusses some potential solutions. Full article

The pursuit of nutraceuticals to improve the quality of life for patients with neurodegenerative conditions is a dynamic field within neuropharmacology. Unfortunately, many nutraceuticals that show promise in preclinical studies fail to demonstrate significant clinical benefits in human trials, leading to their exclusion as therapeutic options. This discrepancy may stem from the categorical interpretation of preclinical and clinical results. Basic researchers often assume that non-human experimental animals exhibit less phenotypic variability than humans. This belief overlooks interindividual phenotype variation, thereby leading to categorical conclusions being drawn from experiments. Consequently, when human clinical trials are conducted, the researchers expect similarly conclusive results. If these results are not achieved, the nutraceutical is deemed ineffective for clinical use, even if numerous individuals might benefit. In our study, we evaluated whether analyzing phenotype variability and similarity through non-categorical methods could help identify rotenone (ROT)-treated rats that might benefit from consuming nano-emulsified punicic acid (Nano-PSO), even if the prevention of “parkinsonism” or the restoration of neurometabolic function is inconsistent across individuals. Our findings supported this hypothesis. The benefits of Nano-PSO were not categorical; however, analyzing phenotype variance allowed us to identify ROT rats with varying degrees of benefit from Nano-PSO consumption. Hence, the translational potential of results from basic science studies testing nutraceuticals as pharmaceutical products against neurodegeneration may improve if researchers also interpret their results using non-categorical methods of data analysis for population screening, even if the overall therapeutic outcomes for the entire population show internal inconsistencies. Full article

Objectives: We aimed to assess the relationship among circulating extracellular vesicles (EVs), hypoxia-related proteins, and the conventional risk factors of life-threatening coronary artery disease (CAD) to find more precise novel biomarkers. Methods: Patients were categorized based on coronary CT angiography. Patients with a Segment Involvement Score > 5 were identified as CAD patients. Individuals with a Segment Involvement Score < 5 were considered control subjects. The characterization of EVs and analysis of the plasma concentration of growth differentiation factor-15 were performed using multicolor or bead-based flow cytometry. The plasma protein levels of glycogen phosphorylase, muscle form, clusterin, and carboxypeptidase N subunit 1 were determined using an enzyme-linked immunosorbent assay. Multiple logistic regression was used to determine the association of the biomarkers with the CAD outcome after accounting for established risk factors. The analysis was built in three steps: first, we included the basic clinical and laboratory variables (Model 1), then we integrated the plasma protein values (Model 2), and finally, we complemented it with the circulating EV pattern (Model 3). To assess the discrimination value of the models, an area under (AUC) the receiver operating curve was calculated and compared across the three models. Results: The area under the curve (AUC) values were 0.68, 0.77, and 0.84 in Models 1, 2, and 3, respectively. The variables with the greatest impact on the AUC values were hemoglobin (0.2 (0.16–0.26)) in Model 1, carboxypeptidase N subunit 1 (0.12 (0.09–0.14)) in Model 2, and circulating CD41+/CD61+ EVs (0.31 (0.15–0.5)) in Model 3. A correlation analysis showed a significant impact of circulating CD41+/CD61+ platelet-derived EVs (p = 0.03, r = −0.4176) in Model 3. Conclusions: Based on our results, the circulating EV profile can be used as a supportive biomarker, along with the conventional laboratory markers of CAD, and it enables a more sensitive, non-invasive diagnostic analysis of CAD. Full article

There are a series of problems in the drilling process of deep heterogeneous formations, such as severe drilling string vibration, slow rock-breaking drilling speed, and the short practical working life of drill bits. It is urgent to develop supporting technical methods for breakthroughs. Based on the main characteristics of the drilling environment in deep formations and the results of drilling string dynamics research in recent years, a technical equipment design concept was proposed to use the vibration of the drill string during the drilling process in heterogeneous formations to improve the hydraulic energy of the bottom hole drilling fluid and thus improve the drilling speed. A technical equipment research and development design was carried out to use the vibration energy of the drill string to enhance the injection energy of the bottom hole drilling medium, and a vibration reduction and energy enhancement device for the bottom hole drill string was developed; we conducted on-site acceleration effect testing, and the research results showed that the vibration of the drill string contains enormous energy, which can be converted into rock-breaking acceleration energy; The designed vibration reduction and energy enhancement device for the bottom hole drilling string can enhance the injection energy of drilling fluid, and reduce the harm of preparing a string vibration; The vibration reduction and energy enhancement device of the bottom hole drill string can significantly improve the drilling speed. The research results have opened up new directions for deep well acceleration technology and provided equipment support for accelerating the exploration and development of deep oil and gas resources. It is recommended to strengthen further the research on the basic theory of downhole drill string vibration, the acceleration technology equipment based on drill string vibration, and vibration acceleration methods. Full article

Background: The growing body of knowledge on the human genome and its variants points towards the significance of genetic factors in oral health and disease. Since the dental curricula have historically prioritized clinically oriented subjects, this focus has resulted in insufficient coverage of genetics. To leverage this knowledge in patient care, dental education must equip students with an understanding of the principles of genetics. Method: We have established “Genetic Educators Network in Dentistry” (GEN-Dent) to identify common concerns regarding genetics in dental education and work for a greater emphasis on genetics in future dental programs to make sure that professionals in dentistry are well-prepared to navigate the complexities of the evolving “human genome era”. Results: Here, GEN-Dent proposes specific learning goals for medical genetics in dentistry and provides supporting teaching material addressing each learning goal. The five life-like case studies exemplify different dental conditions and introduce important concepts of genetics, inspiring other educators. Conclusions: Opportunities in Scandinavian countries can be an advantage in increasing global awareness of the importance of genetics in dentistry. The integration of genetics into dental education not only aims to improve patient care but also seeks to inspire a new generation of basic scientists with clinical backgrounds in dentistry. We expect that using life-like patient cases will significantly motivate dental students when learning medical genetics. Full article

In the Basic College Mathematics Course (BCMC) teaching, the contents are generally based on two-valued logic; however, fuzziness is commonly presented in real life. This leads to the insufficient cultivation of students’ innovative abilities, which constrains the expansion of students’ scientific thinking boundaries and, furthermore, the sustainability of course teaching. First, from the perspective of continuous effectiveness of course content in students’ subsequent learning and research, the connotation of sustainability of BCMC teaching was discussed. Then, based on the analysis of the basic methods of fuzzy sets, their role in cultivating students’ innovative abilities was explored. Next, focused on the three common BCMCs, namely, advanced mathematics, probability theory and mathematical statistics, and linear algebra, the specific teaching concepts and ideas were designed by integrating the fuzzy set methods. Finally, the exploratory teaching mode and approaches of integrating fuzzy set ideas into BCMCs were proposed. The proposed teaching approach helps to extend learners’ thinking boundaries, thereby providing support for cultivating students’ innovation ability and enhancing the sustained effects of course teaching. This study can also provide references for other course teaching. Full article

Background/Objectives: This study investigated the experiences of inpatient family caregivers who experienced restrictions in meeting their family members owing to the changed visitation guidelines of long-term care hospitals during the early stages of the coronavirus disease 2019 (COVID-19). We aimed to deepen our understanding of the nature of these caregivers’ experiences. Methods: The participants were family caregivers of patients in long-term care hospitals during the early stages of the COVID-19 pandemic. We collected data from nine inpatient caregivers from April to July 2021. Individual interviews and data were analyzed using Colaizzi’s phenomenological method. Results: Participants’ experiences were classified into the following three themes: (1) a prison-like long-term care hospital bound by strict COVID-19 prevention rules; (2) growing affection for unreachable parents; and (3) adaptation to a new, safer daily life. Participants had difficulty communicating with their families living under quarantine conditions during COVID-19 due to non-face-to-face situations. However, amid the long-term COVID-19 situation, participants overcame these challenges through efforts to facilitate communication. Conclusions: The results of this study can be used as basic data to support the smooth communication between patients and caregivers in long-term care hospitals in the event of an infectious disease outbreak in the future, to alleviate emotional stress, and to minimize the weakening of families. Full article

Children and adolescents face a wide variety of developmental changes and environmental challenges, and it is estimated that at least one in five children aged 3–17 will experience behavioral or mental health issues. This period of life coincides with major changes in brain structure and function that have profound long-term consequences for learning, decision-making (including risk taking), and emotional processing. For example, continued development of the prefrontal cortex in adolescence is a sensitive period during which individuals are particularly susceptible to risky behaviors, environmental stressors, and substance use. While recent advances in mental health literacy programs have paved the way for increased awareness of the benefits of mental health curricula in schools, these efforts could be greatly bolstered with support in basic neuroscience education in developmentally appropriate and area-specific content. Here, we provide a discussion on the basic structural and functional changes occurring in the brain throughout childhood, how this contributes to changes in cognitive function, and the risk factors posed by early life adversity, stress, and drug use. Finally, we provide a perspective on the benefits of integrating findings from the field of neuroscience and suggestions for tools to better equip students, teachers, administrators, and school mental health staff to provide new directions for addressing the mental health crises faced by millions of children and youth each year. Full article