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14 pages, 2171 KiB  
Article
An Ultra-Low-Voltage Transconductance Stable and Enhanced OTA for ECG Signal Processing
by Yue Yin, Xinbing Zhang, Ziting Feng, Haobo Qi, Haodong Lu, Jiayu He, Chaoqi Jin and Yihao Luo
Micromachines 2024, 15(9), 1108; https://doi.org/10.3390/mi15091108 - 30 Aug 2024
Viewed by 868
Abstract
In this paper, a rail-to-rail transconductance stable and enhanced ultra-low-voltage operational transconductance amplifier (OTA) is proposed for electrocardiogram (ECG) signal processing. The variation regularity of the bulk transconductance of pMOS and nMOS transistors and the cancellation mechanism of two types of transconductance variations [...] Read more.
In this paper, a rail-to-rail transconductance stable and enhanced ultra-low-voltage operational transconductance amplifier (OTA) is proposed for electrocardiogram (ECG) signal processing. The variation regularity of the bulk transconductance of pMOS and nMOS transistors and the cancellation mechanism of two types of transconductance variations are revealed. On this basis, a transconductance stabilization and enhancement technique is proposed. By using the “current-reused and transconductance-boosted complementary bulk-driven pseudo-differential pairs” structure, the bulk-driven pseudo-differential pair during the input common-mode range (ICMR) is stabilized and enhanced. The proposed OTA based on this technology is simulated using the TSMC 0.18 μm process in a Cadence environment. The proposed OTA consumes a power below 30 nW at a 0.4 V voltage supply with a DC gain of 54.9 dB and a gain-bandwidth product (GBW) of 14.4 kHz under a 15 pF capacitance load. The OTA has a high small signal figure-of-merit (FoM) of 7410 and excellent common-mode voltage (VCM) stability, with a transconductance variation of about 1.35%. Based on a current-scaling version of the proposed OTA, an OTA-C low-pass filter (LPF) for ECG signal processing with VCM stability is built and simulated. With a −3 dB bandwidth of 250 Hz and a power consumption of 20.23 nW, the filter achieves a FoM of 3.41 × 10−13, demonstrating good performance. Full article
(This article belongs to the Topic Advanced Integrated Circuit Design and Application)
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<p>Conventional bulk-driven pseudo-differential input amplifier.</p>
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<p>(<b>a</b>) Complementary bulk-driven pseudo-differential pairs, (<b>b</b>) current-reused bulk-driven pseudo-differential pairs, (<b>c</b>) current-reused bulk-driven pseudo-differential pairs with correction.</p>
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<p>(<b>a</b>) The proposed OTA, (<b>b</b>) the LPF, and (<b>c</b>) the layout of BPF without capacitances.</p>
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<p>Pre-simulation and post-simulation results of the proposed and conventional OTAs: (<b>a</b>) amplitude-frequency characteristic, (<b>b</b>) Gm at different <math display="inline"><semantics> <mrow> <mi mathvariant="italic">VCM</mi> </mrow> </semantics></math>, (<b>c</b>) input-referred noise @ <math display="inline"><semantics> <mrow> <mi mathvariant="italic">VCM</mi> </mrow> </semantics></math> = 200 mV and (<b>d</b>) Gm at different process corners and temperatures.</p>
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<p>Pre-simulation and post-simulation results of the filter: (<b>a</b>) amplitude-frequency characteristic of the LPF and (<b>b</b>) the input and output ECG signals.</p>
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14 pages, 636 KiB  
Article
A Capacitive-Feedback Amplifier with 0.1% THD and 1.18 μVrms Noise for ECG Recording
by Xi Chen, Taishan Mo, Peng Wu and Bin Wu
Electronics 2024, 13(2), 378; https://doi.org/10.3390/electronics13020378 - 17 Jan 2024
Cited by 1 | Viewed by 1779
Abstract
This paper presents an amplifier with low noise, high gain, low power consumption, and high linearity for electrocardiogram (ECG) recording. The core of this design is a chopper-stabilized capacitive-feedback operational transconductance amplifier (OTA). The proposed OTA has a two-stage structure, with the first [...] Read more.
This paper presents an amplifier with low noise, high gain, low power consumption, and high linearity for electrocardiogram (ECG) recording. The core of this design is a chopper-stabilized capacitive-feedback operational transconductance amplifier (OTA). The proposed OTA has a two-stage structure, with the first stage using a combination of current reuse and cascode techniques to obtain a large gain at low power and the second stage operating in Class A state for better linearity. The amplifier additionally uses a DC servo loop (DSL) to improve the rejection of DC offsets. The amplifier is implemented in a standard 0.13 μm CMOS process, consuming 1.647 μA current from the supply voltage of 1.5 V and occupying an area of 0.97 mm2. The amplifier has a 0.5 Hz to 6.1 kHz bandwidth and 59.7 dB gain while having no less than a 65 dB common-mode rejection ratio (CMRR). The amplifier’s total harmonic distortion (THD) is less than 0.1% at 800 mVpp output. The amplifier can provide a noise level of 1.18 μVrms in the 0.5 Hz to 500 Hz bandwidth that the ECG signal is interested in and has 3.38 μVrms input-referred noise (IRN) over the entire bandwidth, so its noise efficiency factor (NEF) is 2.13. Full article
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<p>The system structure of the proposed amplifier.</p>
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<p>The core circuit structure of the OTA.</p>
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<p>Analysis and simplification of cascode structure.</p>
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<p>The small-signal model of the OTA.</p>
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<p>Circuit structure of the error amplifier in the common-mode feedback loop.</p>
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<p>Layout of the amplifier.</p>
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<p>Power consumption distribution for the amplifier.</p>
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<p>Simulation of the frequency response.</p>
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<p>Frequency spectrum for a 100 Hz input sinusoid signal.</p>
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<p>Simulation of input-referred noise.</p>
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16 pages, 1947 KiB  
Article
Stress Level Detection Based on the Capacitive Electrocardiogram Signals of Driving Subjects
by Tamara Škorić
Sensors 2023, 23(22), 9158; https://doi.org/10.3390/s23229158 - 14 Nov 2023
Cited by 3 | Viewed by 1378
Abstract
The automotive industry and scientific community are making efforts to develop innovative solutions that would increase successful driver performance in preventing crashes caused by drivers’ health and concentration. High stress is one of the causes of impaired driver performance. This study investigates the [...] Read more.
The automotive industry and scientific community are making efforts to develop innovative solutions that would increase successful driver performance in preventing crashes caused by drivers’ health and concentration. High stress is one of the causes of impaired driver performance. This study investigates the ability to classify different stress levels based on capacitive electrocardiogram (cECG) recorded during driving by unobtrusive acquisition systems with different hardware implementations. The proposed machine-learning model extracted only four features, based on the detection of the R peak, which is the most reliably detected characteristic point even in inferior quality cECG. Another criterion for selecting the features is their low computational complexity, which enables real-time application. The proposed method was validated on three open data sets recorded during driving: electrocardiogram (ECG) recorded by electrodes with direct skin contact (high quality); cECG recorded without direct skin contact through clothes by electrodes built into a portable multi-modal cushion (middle quality); and cECG recorded through the clothes without direct skin contact by electrodes built into a car seat (lowest quality). The proposed model achieved a high accuracy of 100% for high-quality ECG, 96.67% for middle-quality cECG, and 98.08% for the lower-quality cECG. Full article
(This article belongs to the Topic Communications Challenges in Health and Well-Being)
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<p>Block scheme of procedure for stress classification during driving. Feature list: heart rate (<span class="html-italic">HR</span>), R peaks value (local maximum in ECG), and percentage of differences between adjacent normal cardiac intervals (<span class="html-italic">pNN</span>) and binarized approximate entropy (<span class="html-italic">BinEn</span>).</p>
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<p>Raw and denoised cECG time series recorded during ST 1 and ST 2 of experiment, Database 2: (<b>a</b>) denoised (dark green line) cECG time series recorded during driving in the salient environment (without talking with driver); (<b>b</b>) raw (black line) and denoised (dark green line) cECG time series recorded during moving driver according to predefined protocol (ST 2, Database 2).</p>
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<p>Example of raw (black line) and denoised ECG (dark green) recorded by direct driver’s skin contact during driving.</p>
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<p>Comparison of the mean value of percentage [%] of eliminated samples ± SD for (c)ECG in Database 1 (marked by the dark gray bar), Database 2 (marked by the light gray bar), and Database 3 (marked by the dark green bar).</p>
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<p>Comparative presentation of the mean ± standard deviation of (<b>a</b>) <span class="html-italic">BinEn</span>, (<b>b</b>) <span class="html-italic">HR</span>, (<b>c</b>) <span class="html-italic">pNNx</span> and (<b>d</b>) R peaks value of cECG from Database 1, Database 2, and Database 3. Statistical significance is observed between <span class="html-italic">cECG</span> recorded in ST 1 and <span class="html-italic">cECG</span> recorded in ST 3 (marked *) for <span class="html-italic">BinEn</span>, <span class="html-italic">HR</span>, <span class="html-italic">pNNx</span>, and R peak values (Database 2). Statistical significance is observed between <span class="html-italic">cECG</span> recorded in ST 1 and <span class="html-italic">cECG</span> recorded in ST 2 (marked #) only for R peaks value (Database 2). In case of driving in the city and open roads (highways and polygon), there is statistical significance for <span class="html-italic">HR</span> and <span class="html-italic">pNNx</span> (marked by **). Statistical significance was observed only for <span class="html-italic">pNNx</span> in case driving in the city and driving on the highways (marked by ***).</p>
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23 pages, 5861 KiB  
Article
Design and Development of a Non-Contact ECG-Based Human Emotion Recognition System Using SVM and RF Classifiers
by Aftab Alam, Shabana Urooj and Abdul Quaiyum Ansari
Diagnostics 2023, 13(12), 2097; https://doi.org/10.3390/diagnostics13122097 - 16 Jun 2023
Cited by 9 | Viewed by 2528
Abstract
Emotion recognition becomes an important aspect in the development of human-machine interaction (HMI) systems. Positive emotions impact our lives positively, whereas negative emotions may cause a reduction in productivity. Emotionally intelligent systems such as chatbots and artificially intelligent assistant modules help make our [...] Read more.
Emotion recognition becomes an important aspect in the development of human-machine interaction (HMI) systems. Positive emotions impact our lives positively, whereas negative emotions may cause a reduction in productivity. Emotionally intelligent systems such as chatbots and artificially intelligent assistant modules help make our daily life routines effortless. Moreover, a system which is capable of assessing the human emotional state would be very helpful to assess the mental state of a person. Hence, preventive care could be offered before it becomes a mental illness or slides into a state of depression. Researchers have always been curious to find out if a machine could assess human emotions precisely. In this work, a unimodal emotion classifier system in which one of the physiological signals, an electrocardiogram (ECG) signal, has been used is proposed to classify human emotions. The ECG signal was acquired using a capacitive sensor-based non-contact ECG belt system. The machine-learning-based classifiers developed in this work are SVM and random forest with 10-fold cross-validation on three different sets of ECG data acquired for 45 subjects (15 subjects in each age group). The minimum classification accuracies achieved with SVM and RF emotion classifier models are 86.6% and 98.2%, respectively. Full article
(This article belongs to the Section Point-of-Care Diagnostics and Devices)
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<p>Functional block diagram of the proposed human emotion recognition system.</p>
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<p>Block diagram of the ECG data acquisition system.</p>
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<p>Process flow chart of the emotion recognition model.</p>
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<p>ECG signal on serial plotter of Arduino IDE.</p>
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<p>A normalized ECG signal in time-domain.</p>
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<p>The pre-processed sampled ECG signal.</p>
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<p>Snapshot of the experimental setup.</p>
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<p>Confusion matrices of the SVM quadratic classifier: (<b>a</b>) Set A feature dataset; (<b>b</b>) Set B feature dataset; (<b>c</b>) Set C feature dataset; (<b>d</b>) combined feature dataset.</p>
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<p>Confusion Matrices of SVM Optimizable and minimum classification error plot (<b>A</b>). Set A Feature dataset: (a) confusion matrix (b) minimum classification error plot (<b>B</b>). Set B Feature dataset: (a) confusion matrix (b) minimum classification error plot (<b>C</b>). Set C Feature dataset: (a) confusion matrix (b) minimum classification error plot (<b>D</b>). Combined Feature dataset: (a) confusion matrix (b) minimum classification error plot.</p>
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<p>Confusion matrices of the ensemble bagged tree classifier: (<b>a</b>) Set A feature dataset; (<b>b</b>) Set B feature dataset; (<b>c</b>) Set C feature dataset; (<b>d</b>) combined feature dataset.</p>
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<p>Confusion Matrices of Ensemble Optimizable and minimum classification error plot (<b>A</b>). Set A Feature dataset: (a) confusion matrix (b) minimum classification error plot (<b>B</b>). Set B Feature dataset: (a) confusion matrix (b) minimum classification error plot (<b>C</b>). Set C Feature dataset: (a) confusion matrix (b) minimum classification error plot (<b>D</b>). Combined Feature dataset: (a) confusion matrix (b) minimum classification error plot.</p>
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<p>AUC- ROC plot for all seven categories of emotions in case of SVM Quadratic model (Set-A). (<b>a</b>) positive class: Anger (<b>b</b>) positive class: Disgust (<b>c</b>) positive class: Fear (<b>d</b>) positive class: Happy (<b>e</b>) positive class: Neutral (<b>f</b>) positive class: Sad (<b>g</b>) positive class: Surprise.</p>
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<p>Comparison bar graph of classification accuracies for emotion classifier models.</p>
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21 pages, 12879 KiB  
Article
A Portable Multi-Modal Cushion for Continuous Monitoring of a Driver’s Vital Signs
by Onno Linschmann, Durmus Umutcan Uguz, Bianca Romanski, Immo Baarlink, Pujitha Gunaratne, Steffen Leonhardt, Marian Walter and Markus Lueken
Sensors 2023, 23(8), 4002; https://doi.org/10.3390/s23084002 - 14 Apr 2023
Cited by 6 | Viewed by 2342
Abstract
With higher levels of automation in vehicles, the need for robust driver monitoring systems increases, since it must be ensured that the driver can intervene at any moment. Drowsiness, stress and alcohol are still the main sources of driver distraction. However, physiological problems [...] Read more.
With higher levels of automation in vehicles, the need for robust driver monitoring systems increases, since it must be ensured that the driver can intervene at any moment. Drowsiness, stress and alcohol are still the main sources of driver distraction. However, physiological problems such as heart attacks and strokes also exhibit a significant risk for driver safety, especially with respect to the ageing population. In this paper, a portable cushion with four sensor units with multiple measurement modalities is presented. Capacitive electrocardiography, reflective photophlethysmography, magnetic induction measurement and seismocardiography are performed with the embedded sensors. The device can monitor the heart and respiratory rates of a vehicle driver. The promising results of the first proof-of-concept study with twenty participants in a driving simulator not only demonstrate the accuracy of the heart (above 70% of medical-grade heart rate estimations according to IEC 60601-2-27) and respiratory rate measurements (around 30% with errors below 2 BPM), but also that the cushion might be useful to monitor morphological changes in the capacitive electrocardiogram in some cases. The measurements can potentially be used to detect drowsiness and stress and thus the fitness of the driver, since heart rate variability and breathing rate variability can be captured. They are also useful for the early prediction of cardiovascular diseases, one of the main reasons for premature death. The data are publicly available in the UnoVis dataset. Full article
(This article belongs to the Special Issue Sensors for Smart Vehicle Applications)
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<p>Model of active electrode (altered from [<a href="#B17-sensors-23-04002" class="html-bibr">17</a>]).</p>
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<p>Principle of reflective PPG (inspired by [<a href="#B37-sensors-23-04002" class="html-bibr">37</a>]).</p>
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<p>Principle of MIM (altered from [<a href="#B19-sensors-23-04002" class="html-bibr">19</a>]).</p>
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<p>System overview. On the left side, a block diagram of the system is depicted. The orange highlighted block depicts the top side of the PCB (shown on the top right). The blue highlighted block depicts the bottom side of the PCB. On the right side, the cushion with the controller box is depicted.</p>
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<p>Simulator and protocol.</p>
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<p>Workflow for processing of signals. Please note that the peak detection for the cECG signals is performed with the Pan–Tompkins algorithm and the algorithm of Brüser et al. is used to extract the HR of the SCG.</p>
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<p>Signals with good quality. The reference peaks of the conductive ECG and impedance pneumography are shown as dashed red or blue lines, respectively.</p>
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<p>Signals with bad quality. The reference peaks of the conductive ECG and impedance pneumography are shown as dashed red or blue lines, respectively.</p>
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<p>Example of unreliable respiratory reference. The respiratory signals extracted from rPPG<math display="inline"><semantics> <msub> <mrow/> <mn>1</mn> </msub> </semantics></math> and rPPG<math display="inline"><semantics> <msub> <mrow/> <mn>3</mn> </msub> </semantics></math> are shown for comparison.</p>
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<p>AUC of HR for different stages for cECG and reflective PPG. The bar shows the median across all participants and the lines show the standard deviation.</p>
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<p>AUC of RR for different stages for cECG, MIM and reflective PPG. The bar shows the median across all participants and the lines show the standard deviation.</p>
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<p>AUC of RR for different stages for SCG. The bar shows the median across all participants and the lines show the standard deviation.</p>
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23 pages, 10805 KiB  
Article
3.6 mW Active-Electrode ECG/ETI Sensor System Using Wideband Low-Noise Instrumentation Amplifier and High Impedance Balanced Current Driver
by Xuan Tien Nguyen, Muhammad Ali and Jong-Wook Lee
Sensors 2023, 23(5), 2536; https://doi.org/10.3390/s23052536 - 24 Feb 2023
Viewed by 2535
Abstract
An active electrode (AE) and back-end (BE) integrated system for enhanced electrocardiogram (ECG)/electrode-tissue impedance (ETI) measurement is proposed. The AE consists of a balanced current driver and a preamplifier. To increase the output impedance, the current driver uses a matched current source and [...] Read more.
An active electrode (AE) and back-end (BE) integrated system for enhanced electrocardiogram (ECG)/electrode-tissue impedance (ETI) measurement is proposed. The AE consists of a balanced current driver and a preamplifier. To increase the output impedance, the current driver uses a matched current source and sink, which operates under negative feedback. To increase the linear input range, a new source degeneration method is proposed. The preamplifier is realized using a capacitively-coupled instrumentation amplifier (CCIA) with a ripple-reduction loop (RRL). Compared to the traditional Miller compensation, active frequency feedback compensation (AFFC) achieves bandwidth extension using the reduced size of the compensation capacitor. The BE performs three types of signal sensing: ECG, band power (BP), and impedance (IMP) data. The BP channel is used to detect the Q-, R-, and S-wave (QRS) complex in the ECG signal. The IMP channel measures the resistance and reactance of the electrode-tissue. The integrated circuits for the ECG/ETI system are realized in the 180 nm CMOS process and occupy a 1.26 mm2 area. The measured results show that the current driver supplies a relatively high current (>600 μApp) and achieves a high output impedance (1 MΩ at 500 kHz). The ETI system can detect resistance and capacitance in the ranges of 10 mΩ–3 kΩ and 100 nF–100 μF, respectively. The ECG/ETI system consumes 3.6 mW using a single 1.8 V supply. Full article
(This article belongs to the Special Issue Advanced CMOS Integrated Circuit Design and Application II)
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<p>Block diagram for the ECG/ETI measurement system.</p>
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<p>Schematic of electrode-tissue impedance (ETI) measurement.</p>
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<p>Schematic of the balanced current driver.</p>
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<p>Source degeneration method using (<b>a</b>) conventional and (<b>b</b>) proposed approach. (<b>c</b>) Comparison of the transfer characteristics.</p>
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<p>Schematic of the differential difference amplifier. Circuits for source degeneration is shown in blue color. (W/L)<sub>3A,3B</sub> = (W/L)<sub>6A,6B</sub> = 1 μm/0.7 μm. <span class="html-italic">R</span><sub>b1,b2</sub> is realized using a diode-connected transistor having a size of (W/L) = 0.9 μm /0.7 μm. <span class="html-italic">C</span><sub>b1,b2</sub> = 0.32 pF.</p>
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<p>Schematic of the transconductor.</p>
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<p>Schematic of the CCIA using active feedback frequency compensation (AFFC) and ripple-reduction loop (RRL). <span class="html-italic">C</span><sub>in1,2</sub> = 15 pF, <span class="html-italic">C</span><sub>fb1,2</sub> = 0.14 pF.</p>
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<p>Schematic of the folded-cascode amplifier with common-mode feedback.</p>
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<p>Equivalent small-signal circuit of the amplifier for calculating the open-loop gain.</p>
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<p>Comparison of the open-loop gain of the amplifier using AFFC and traditional Miller compensation.</p>
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<p>Schematic showing the operation of the ripple-reduction loop.</p>
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<p>Block diagram of the back-end signal processing IC. The spectrums of the ECG and IMP channels are shown in the inset.</p>
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<p>Schematic of the instrumentation amplifier.</p>
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<p>Schematic of the PGA.</p>
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<p>Schematic of the low-pass filter.</p>
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<p>Simulated frequency responses of the low-pass filters.</p>
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<p>Microphotograph of (<b>a</b>) current driver, (<b>b</b>) preamplifier, (<b>c</b>) back-end signal processing IC.</p>
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<p>Measure transconductances as a function of input voltage.</p>
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<p>(<b>a</b>) Schematic of characterizing the output impedance. (<b>b</b>) Measured output current as a function of frequency under different inputs. (<b>c</b>) Measured output current as a function of load impedance under different inputs.</p>
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<p>(<b>a</b>) Schematic of characterizing the output impedance. (<b>b</b>) Measured output current as a function of frequency under different inputs. (<b>c</b>) Measured output current as a function of load impedance under different inputs.</p>
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<p>(<b>a</b>) Measured gain of the CCIA, (<b>b</b>) measured input-referred noise voltage spectral density of the CCIA for the active electrode.</p>
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<p>(<b>a</b>) Measured gain of the CCIA, (<b>b</b>) measured input-referred noise voltage spectral density of the CCIA for the active electrode.</p>
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<p>Measured frequency response of the ECG channel for eight gain settings.</p>
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<p>Measured input-referred noise voltage spectral density of the ECG channel.</p>
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<p>Measured amplified ECG signal.</p>
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<p>Measured result of the impedance channel. The current driver injects input at three frequencies (1 kHz, 4 kHz, and 5 kHz). The demodulation is performed at 5 kHz.</p>
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<p>Measured range of the ETI system for (<b>a</b>) differential resistance and (<b>b</b>) differential capacitance. The values of the injected current are also shown.</p>
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<p>Measured result of band power channels. Positive and negative inputs are indicated with blue and red lines, and output is indicated with black lines.</p>
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<p>Measured waveforms of the ECG and IMP channels.</p>
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<p>Flowchart of the ECG peak detection algorithm.</p>
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<p>Waveforms of the ECG signal and detected peaks.</p>
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17 pages, 8852 KiB  
Article
Non-Contact Monitoring of ECG in the Home Environment—Selecting Optimal Electrode Configuration
by Adam Bujnowski, Kamil Osiński, Piotr Przystup and Jerzy Wtorek
Sensors 2022, 22(23), 9475; https://doi.org/10.3390/s22239475 - 4 Dec 2022
Cited by 2 | Viewed by 2542
Abstract
Capacitive electrocardiography (cECG) is most often used in wearable or embedded measurement systems. The latter is considered in the paper. An optimal electrocardiographic lead, as an individual feature, was determined based on model studies. It was defined as the possibly highest value of [...] Read more.
Capacitive electrocardiography (cECG) is most often used in wearable or embedded measurement systems. The latter is considered in the paper. An optimal electrocardiographic lead, as an individual feature, was determined based on model studies. It was defined as the possibly highest value of the R-wave amplitude measured on the back of the examined person. The lead configuration was also analyzed in terms of minimizing its susceptibility to creating motion artifacts. It was found that the direction of the optimal lead coincides with the electrical axis of the heart. Moreover, the electrodes should be placed in the areas preserving the greatest voltage and at the same time characterized by the lowest gradient of the potential. Experimental studies were conducted using the developed measurement system on a group of 14 people. The ratio of the R-wave amplitude (as measured on the back and chest, using optimal leads) was less than 1 while the SNR reached at least 20 dB. These parameters allowed for high-quality QRS complex detection with a PPV of 97%. For the “worst” configurations of the leads, the signals measured were practically uninterpretable. Full article
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<p>Measurement system enabling recording contact and non-contact electrocardiograms.</p>
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<p>Developed FEM model used in the study.</p>
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<p>Exemplary results of the potential distribution, on the chest and back, respectively, at the moment of the R wave of the ECG for two selected heart axis directions which differ in the azimuthal angle value, (<b>a</b>,<b>b</b>) present the potential distribution, respectively, on the chest and the back for azimuthal angle <math display="inline"><semantics> <mrow> <mi>π</mi> <mo>/</mo> <mn>2</mn> </mrow> </semantics></math>, while (<b>c</b>,<b>d</b>) present the potential distribution, respectively, on the chest and the back for azimuthal angle <math display="inline"><semantics> <mrow> <mn>3</mn> <mi>π</mi> <mo>/</mo> <mn>4</mn> </mrow> </semantics></math>. Note that the azimuthal angle is determined in reference to the x-axis and that different scales are accepted for the figures.</p>
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<p>Electric field distribution on the back (<b>a</b>) Ex, (<b>b</b>) Ey, and (<b>c</b>) Ez components, respectively.</p>
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<p>(<b>a</b>–<b>d</b>) Configuration of the leads (see text for details) used in the study for measuring ECG on the back (illustrative figures). Two signals were recorded simultaneously using contact (red circle) and non-contact (green square), respectively. Reference to sub-figures inside text.</p>
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<p>Developed capacitive electrode: (<b>a</b>) circuit diagram, (<b>b</b>) measurement system (DRL electrode not shown), (<b>c</b>) frequency characteristic of the measurement system as determined by an AD8232.</p>
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<p>Simultaneous recording of ECG and cECG using different leads presented in <a href="#sensors-22-09475-f005" class="html-fig">Figure 5</a>; (<b>a</b>) A’A lead, (<b>b</b>) B’B lead, and (<b>c</b>) DD’ lead. The signals were recorded for the person; the heart’s electrical axis was almost parallel to the I Eindhoven lead.</p>
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<p>Relation between averaged values of R-wave as measured on the chest and the back using the optimal leads for the whole group of volunteers.</p>
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<p>Relation between the R-wave amplitudes as measured for different leads including the optimal one (marked blue) and two others. <math display="inline"><semantics> <mrow> <mi>A</mi> <mi>v</mi> <msub> <mi>g</mi> <mn>0</mn> </msub> </mrow> </semantics></math> represents the optimal lead, while <math display="inline"><semantics> <mrow> <mi>A</mi> <mi>v</mi> <msub> <mi>g</mi> <mn>1</mn> </msub> <mn>5</mn> </mrow> </semantics></math> and <math display="inline"><semantics> <mrow> <mi>A</mi> <mi>v</mi> <msub> <mi>g</mi> <mn>3</mn> </msub> <mn>0</mn> </mrow> </semantics></math> represent the leads, forming angles of 15 and 30 degrees from the optimal ones, respectively.</p>
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<p>Example of cECG signal recorded for a period of 15 minutes (<b>a</b>) and part of the signal shown for a different time scale (<b>b</b>).</p>
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<p>Detection of the R wave in the QRS complex—vertical red lines indicate the positions of the R-wave detected.</p>
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14 pages, 4376 KiB  
Article
Development and Optimization of Silicon−Dioxide−Coated Capacitive Electrode for Ambulatory ECG Measurement System
by Younghwan Kang, Sangdong Choi, Chiwan Koo and Yeunho Joung
Sensors 2022, 22(21), 8388; https://doi.org/10.3390/s22218388 - 1 Nov 2022
Cited by 2 | Viewed by 2248
Abstract
This paper presents a silicon−dioxide−coated capacitive electrode system for an ambulatory electrocardiogram (ECG). The electrode was coated with a nano−leveled (287 nm) silicon dioxide layer which has a very high resistance of over 200 MΩ. Due to this high resistance, the electrode can [...] Read more.
This paper presents a silicon−dioxide−coated capacitive electrode system for an ambulatory electrocardiogram (ECG). The electrode was coated with a nano−leveled (287 nm) silicon dioxide layer which has a very high resistance of over 200 MΩ. Due to this high resistance, the electrode can be defined as only a capacitor without a resistive characteristic. This distinct capacitive characteristic of the electrode brings a simplified circuit analysis to achieve the development of a high−quality ambulatory ECG system. The 240 um thickness electrode was composed of a stainless−steel sheet layer for sensing, a polyimide electrical insulation layer, and a copper sheet connected with the ground to block any electrical noises generated from the back side of the structure. Six different diameter electrodes were prepared to optimize ECG signals in ambulatory environment, such as the amplitude of the QRS complex, amplitude of electromagnetic interference (EMI), and baseline wandering of the ECG signals. By combining the experimental results, optimal ambulatory ECG signals were obtained with electrodes that have a diameter from 1 to 3 cm. Moreover, we achieved high−quality ECG signals in a sweating simulation environment with 2 cm electrodes. Full article
(This article belongs to the Section Wearables)
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<p>Block diagram of ECG measurement circuit.</p>
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<p>Fabrication process flow of silicon−dioxide−coated electrode.</p>
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<p>Silicon−dioxide−coated capacitive−coupled electrode. (<b>a</b>) Structure schematic of the capacitive−coupled electrode. (<b>b</b>) SEM (Fei company, Nova 200 NanoLab) picture of silicon dioxide. (<b>c</b>) Fabricated electrode (diameter: 0.5cm) and total thickness (240 μm). (<b>d</b>) Surface resistance measurement of capacitive−coupled electrode using 4−point probe.</p>
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<p>Schematic of skin–electrode interface. (<b>a</b>) Mechanical connection between electrode and circuit and (<b>b</b>) electrical circuit model of skin–electrode interface.</p>
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<p>Measurement environment. (<b>a</b>) Location of capacitive electrode and (<b>b</b>) ECG measurement board.</p>
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<p>ECG signals of electrode diameter with (<b>a</b>) 0.5 cm, (<b>b</b>) 1 cm, (<b>c</b>) 3 cm, (<b>d</b>) 5 cm, (<b>e</b>) 7 cm, (<b>f</b>) 9 cm, and (<b>g</b>) QRS complex amplitude and standard deviation comparison according to the diameter of electrodes.</p>
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<p>EMI influence according different electrode diameter of (<b>a</b>) 0.5 cm, (<b>b</b>) 1 cm, (<b>c</b>) 3 cm, (<b>d</b>) 5 cm, (<b>e</b>) 7 cm, (<b>f</b>) 9 cm, and (<b>g</b>) EMI influence comparison according to the diameter of electrodes.</p>
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<p>Baseline wandering according different electrode diameter of (<b>a</b>) 0.5 cm (black), (<b>b</b>) 1 cm (red), (<b>c</b>) 3 cm (blue), (<b>d</b>) 5 cm (violet), (<b>e</b>) 7 cm (green), (<b>f</b>) 9 cm (indigo), and (<b>g</b>) box plot of baseline wandering amplitude according to the diameter of electrode.</p>
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<p>Six−minute ECG signals with spraying the saline on the skin. (<b>a</b>) From start to 4 min (<b>b</b>) From 4 to 6 min.</p>
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22 pages, 4727 KiB  
Article
Reduction of Artifacts in Capacitive Electrocardiogram Signals of Driving Subjects
by Tamara Škorić
Entropy 2022, 24(1), 13; https://doi.org/10.3390/e24010013 - 22 Dec 2021
Cited by 5 | Viewed by 3018
Abstract
The development of smart cars with e-health services allows monitoring of the health condition of the driver. Driver comfort is preserved by the use of capacitive electrodes, but the recorded signal is characterized by large artifacts. This paper proposes a method for reducing [...] Read more.
The development of smart cars with e-health services allows monitoring of the health condition of the driver. Driver comfort is preserved by the use of capacitive electrodes, but the recorded signal is characterized by large artifacts. This paper proposes a method for reducing artifacts from the ECG signal recorded by capacitive electrodes (cECG) in moving subjects. Two dominant artifact types are coarse and slow-changing artifacts. Slow-changing artifacts removal by classical filtering is not feasible as the spectral bands of artifacts and cECG overlap, mostly in the band from 0.5 to 15 Hz. We developed a method for artifact removal, based on estimating the fluctuation around linear trend, for both artifact types, including a condition for determining the presence of coarse artifacts. The method was validated on cECG recorded while driving, with the artifacts predominantly due to the movements, as well as on cECG recorded while lying, where the movements were performed according to a predefined protocol. The proposed method eliminates 96% to 100% of the coarse artifacts, while the slow-changing artifacts are completely reduced for the recorded cECG signals larger than 0.3 V. The obtained results are in accordance with the opinion of medical experts. The method is intended for reliable extraction of cardiovascular parameters to monitor driver fatigue status. Full article
(This article belongs to the Special Issue Information Theory in Emerging Biomedical Applications)
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<p>An example of a cECG time series recorded (<b>a</b>) while driving in car, (<b>b</b>) while lying on the bed, (<b>c</b>) enlarged part of useful segments during driving, and (<b>d</b>) enlarged part of useful segments while lying. Red rectangles indicate R peaks marked by medical experts; an example of coarse artifacts is marked by the green rectangular border in (<b>a</b>,<b>b</b>); examples of slow-changing artifacts are marked by the blue rectangular border in (<b>a</b>–<b>c</b>). An example of the useful signal segment that is similar to the useless segment is marked by the brown rectangular border in (<b>c</b>). Slow-changing artifacts were determined by checking the overall accuracy in eliminating useless signal segments.</p>
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<p>cECG time series recorded during driving: (<b>a</b>) <span class="html-italic">cECG<sub>1</sub></span> with a moderate amount of coarse artifacts; (<b>b</b>) <span class="html-italic">cECG<sub>1</sub></span> without coarse artifacts. Red marks useful segments according to medical experts.</p>
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<p>Mean value of percentage of total power of slow-changing artifacts over frequency bands ±<span class="html-italic">SD</span>: (<b>a</b>) <span class="html-italic">cECG</span><span class="html-italic"><sub>1</sub></span> during driving; (<b>b</b>) <span class="html-italic">cECG</span><span class="html-italic"><sub>2</sub></span> during driving.</p>
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<p>Example of extracted part of raw <span class="html-italic">cECG</span> time series recorded while driving. Red rectangles indicate <span class="html-italic">R</span> peaks of <span class="html-italic">cECG</span> signals marked by medical experts, black rectangles indicate peaks detected using OSEA software. Gray vertical lines indicate segments for which the value of the estimated fluctuation <span class="html-italic">F<sub>D</sub></span> is shown in the upper panel. Asterisks (**) indicate characteristic segments that appear next to segments with coarse artifacts.</p>
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<p>Difference between half of the difference maximal and minimum amplitude of the time series, and the square root of the second moment (<b>a</b>) <span class="html-italic">cECG<sub>1</sub></span> and <span class="html-italic">cECG<sub>2</sub></span> time series recorded while driving, (<b>b</b>) <span class="html-italic">cECG<sub>1</sub></span>, <span class="html-italic">cECG<sub>2</sub></span>, and <span class="html-italic">cECG<sub>3</sub></span> time series recorded while lying in bed.</p>
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<p>Difference between half of the difference maximal and minimum amplitude of the time series, and the square root of the second moment (<b>a</b>) <span class="html-italic">cECG<sub>1</sub></span> and <span class="html-italic">cECG<sub>2</sub></span> time series recorded while driving, (<b>b</b>) <span class="html-italic">cECG<sub>1</sub></span>, <span class="html-italic">cECG<sub>2</sub></span>, and <span class="html-italic">cECG<sub>3</sub></span> time series recorded while lying in bed.</p>
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<p>Statistical parameters of the recorded <span class="html-italic">cECG</span> time series for different recording conditions: driving car, lying in bed. (<b>a</b>) Median value of <span class="html-italic">F<sub>D</sub></span>, (<b>b</b>) standard deviation <span class="html-italic">SD</span>(<span class="html-italic">F<sub>D</sub></span>), and (<b>c</b>) standard deviation of <span class="html-italic">cECG</span> time series.</p>
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<p>Influence of empirical parameter C on percentage of preserved R peaks marked by medical experts and percentage of eliminated coarse artifacts for <span class="html-italic">SL</span> = 0.5 s.</p>
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<p>Comparative presentation of the mean value ± SD percentage of eliminated time series by the proposed method and by the opinion of experts: (<b>a</b>) <span class="html-italic">cECG</span> time series recorded while lying on the bed, (<b>b</b>) <span class="html-italic">cECG</span> time series recorded while driving and (<b>c</b>) mean values of absolute amplitudes of <span class="html-italic">cECG</span> time series ± SD. Statistical significance is observed between the raw <span class="html-italic">cECG</span> and <span class="html-italic">cECG</span> after elimination of the artifacts by the proposed method (marked *), as well as the <span class="html-italic">cECG</span> after elimination, according to the experts (marked #). Statistical significance does not exist between the group of signals after elimination of the artifact by the proposed method and in the opinion of experts. We used a <span class="html-italic">t</span>-test for paired samples, with significance levels <span class="html-italic">p</span> &lt; 0.01 for all compared groups.</p>
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<p>(<b>a</b>) Raw <span class="html-italic">cECG<sub>1</sub></span> time series recorded while driving, (<b>b</b>) <span class="html-italic">cECG<sub>3</sub></span> time series recorded while lying on the bed, (<b>c</b>) <span class="html-italic">cECG<sub>1</sub></span> time series after elimination of artifacts by the proposed method, and (<b>d</b>) <span class="html-italic">cECG<sub>3</sub></span> time series after elimination of artifacts by the proposed method.</p>
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<p>Demonstration of the success of eliminating artifacts and preserving the useful part of the signal by the proposed method depending on SL. (<b>a</b>) <span class="html-italic">cECG<sub>1</sub></span>, <span class="html-italic">cECG<sub>2</sub></span> recorded in the car, (<b>b</b>) <span class="html-italic">cECG<sub>1</sub></span>, <span class="html-italic">cECG<sub>2</sub></span>, and <span class="html-italic">cECG<sub>3</sub></span> while lying on the bed, (<b>c</b>) the percentage of time series in which the coarse artifacts are fully eliminated, depending on the SL, and (<b>d</b>) the percentage of lost R peaks after artifacts reduction, depending on the SL.</p>
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<p><span class="html-italic">BinApEn</span> and <span class="html-italic">BinSampEn</span> for <span class="html-italic">cECG</span> of all observed groups. (<b>a</b>) Mean value of <span class="html-italic">BinApEn</span> (<span class="html-italic">m</span> = 2, <span class="html-italic">r</span> = 2) ± SD, (<b>b</b>) mean value of <span class="html-italic">BinApEn</span> (<span class="html-italic">m</span> = 3, <span class="html-italic">r</span> = 1) ± SD, (<b>c</b>) <span class="html-italic">BinSampEn</span> (<span class="html-italic">m</span> = 2, <span class="html-italic">r</span> = 2) ± SD, (<b>d</b>) <span class="html-italic">BinSampEn</span> (<span class="html-italic">m</span> = 3, <span class="html-italic">r</span> = 1) ± SD and (<b>e</b>) mean value of <span class="html-italic">BinApEn</span> ± SD and <span class="html-italic">BinSampEn</span> ± SD for (<span class="html-italic">m</span> = 2, <span class="html-italic">r</span> = 2) and (<span class="html-italic">m</span> = 3, <span class="html-italic">r</span> = 1) of the cECG recorded during driving in the city and in the open road. Statistical significance between BinEn of cECG after elimination of the artifacts during driving in the city and the open road is marked by *.</p>
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<p><span class="html-italic">BinApEn</span> and <span class="html-italic">BinSampEn</span> for <span class="html-italic">cECG</span> of all observed groups. (<b>a</b>) Mean value of <span class="html-italic">BinApEn</span> (<span class="html-italic">m</span> = 2, <span class="html-italic">r</span> = 2) ± SD, (<b>b</b>) mean value of <span class="html-italic">BinApEn</span> (<span class="html-italic">m</span> = 3, <span class="html-italic">r</span> = 1) ± SD, (<b>c</b>) <span class="html-italic">BinSampEn</span> (<span class="html-italic">m</span> = 2, <span class="html-italic">r</span> = 2) ± SD, (<b>d</b>) <span class="html-italic">BinSampEn</span> (<span class="html-italic">m</span> = 3, <span class="html-italic">r</span> = 1) ± SD and (<b>e</b>) mean value of <span class="html-italic">BinApEn</span> ± SD and <span class="html-italic">BinSampEn</span> ± SD for (<span class="html-italic">m</span> = 2, <span class="html-italic">r</span> = 2) and (<span class="html-italic">m</span> = 3, <span class="html-italic">r</span> = 1) of the cECG recorded during driving in the city and in the open road. Statistical significance between BinEn of cECG after elimination of the artifacts during driving in the city and the open road is marked by *.</p>
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<p>Threshold value of <span class="html-italic">TH</span><sub>1</sub> for <span class="html-italic">cECG</span> of all observed groups.</p>
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16 pages, 2341 KiB  
Article
Signal Quality Index Based on Template Cross-Correlation in Multimodal Biosignal Chair for Smart Healthcare
by Seunghyeok Hong, Jeong Heo and Kwang Suk Park
Sensors 2021, 21(22), 7564; https://doi.org/10.3390/s21227564 - 14 Nov 2021
Cited by 6 | Viewed by 3453
Abstract
We investigated the effects of a quality screening method on unconstrained measured signals, including electrocardiogram (ECG), photoplethysmogram (PPG), and ballistocardiogram (BCG) signals, in our collective chair system for smart healthcare. Such an investigation is necessary because unattached or unbound sensors have weaker connections [...] Read more.
We investigated the effects of a quality screening method on unconstrained measured signals, including electrocardiogram (ECG), photoplethysmogram (PPG), and ballistocardiogram (BCG) signals, in our collective chair system for smart healthcare. Such an investigation is necessary because unattached or unbound sensors have weaker connections to body parts than do conventional methods. Using the biosignal chair, the physiological signals collected during sessions included a virtual driving task, a physically powered wheelchair drive, and three types of body motions. The signal quality index was defined by the similarity between the observed signals and noise-free signals from the perspective of the cross-correlations of coefficients with appropriate individual templates. The goal of the index was to qualify signals without a reference signal to assess the practical use of the chair in daily life. As expected, motion artifacts have adverse effects on the stability of physiological signals. However, we were able to observe a supplementary relationship between sensors depending on each movement trait. Except for extreme movements, the signal quality and estimated heart rate (HR) remained within the range of criteria usable for status monitoring. By investigating the signal reliability, we were able to confirm the suitability of using the unconstrained biosignal chair to collect real-life measurements to improve safety and healthcare. Full article
(This article belongs to the Special Issue Long-Term Biological Signals and Sensors)
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<p>System structure and process. ADC: analog-to-digital converter, MCU: microcontroller unit, <span class="html-italic">atCC</span>: averaged template cross-correlation, SQI: signal quality index, HR: heart rate.</p>
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<p>Biosignal chair. (<b>a</b>) Sensor locations. (<b>b</b>) Mainboard. (<b>c</b>) Side view of the wheelchair fastening seatbelt. (<b>d</b>) cECG electrodes with the casing used for the signal enhancement circuit. (<b>e</b>) cPPG probe with 8 LEDs and a PD. (<b>f</b>) EMFi sensor below the seat base for BCG detection.</p>
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<p>(<b>a</b>) BCG with reference ECG and accelerometer signals; (<b>b</b>) BCG template (bold) using serially validated peaks in the rest state of p1.</p>
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<p>Preprocess to search serially correlated peaks.</p>
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<p>The highest (<b>upper figure</b>) and lowest (<b>lower figure</b>) values of the averaged template<span class="html-italic">CC</span> (<span class="html-italic">atCC</span>) derived from the original back cECG for resting states after completion of a motion task by a participant (p7).</p>
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<p>The signal quality index derived by the similarity of the average tCC of the original signals in each movement period (<b>left column</b>) and in the rest state after the arm motion task (<b>right column</b>).</p>
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<p>Bland–Altman and linear regression plots of HRs from the reference ECG signal and from the cPPG signals detected at the hip after screening by each <span class="html-italic">SQI<sub>atCC</sub></span> criterion: (<b>a</b>) <span class="html-italic">SQI<sub>atCC</sub></span> &gt; 60%; (<b>b</b>) <span class="html-italic">SQI<sub>atCC</sub></span> &gt; 70%; (<b>c</b>) <span class="html-italic">SQI<sub>atCC</sub></span> &gt; 80%.</p>
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18 pages, 1982 KiB  
Article
Capacitively-Coupled ECG and Respiration for Sleep–Wake Prediction and Risk Detection in Sleep Apnea Patients
by Dorien Huysmans, Ivan Castro, Pascal Borzée, Aakash Patel, Tom Torfs, Bertien Buyse, Dries Testelmans, Sabine Van Huffel and Carolina Varon
Sensors 2021, 21(19), 6409; https://doi.org/10.3390/s21196409 - 25 Sep 2021
Cited by 3 | Viewed by 2652
Abstract
Obstructive sleep apnea (OSA) patients would strongly benefit from comfortable home diagnosis, during which detection of wakefulness is essential. Therefore, capacitively-coupled electrocardiogram (ccECG) and bioimpedance (ccBioZ) sensors were used to record the sleep of suspected OSA patients, in parallel with polysomnography (PSG). The [...] Read more.
Obstructive sleep apnea (OSA) patients would strongly benefit from comfortable home diagnosis, during which detection of wakefulness is essential. Therefore, capacitively-coupled electrocardiogram (ccECG) and bioimpedance (ccBioZ) sensors were used to record the sleep of suspected OSA patients, in parallel with polysomnography (PSG). The three objectives were quality assessment of the unobtrusive signals during sleep, prediction of sleep–wake using ccECG and ccBioZ, and detection of high-risk OSA patients. First, signal quality indicators (SQIs) determined the data coverage of ccECG and ccBioZ. Then, a multimodal convolutional neural network (CNN) for sleep–wake prediction was tested on these preprocessed ccECG and ccBioZ data. Finally, two indices derived from this prediction detected patients at risk. The data included 187 PSG recordings of suspected OSA patients, 36 (dataset “Test”) of which were recorded simultaneously with PSG, ccECG, and ccBioZ. As a result, two improvements were made compared to prior studies. First, the ccBioZ signal coverage increased significantly due to adaptation of the acquisition system. Secondly, the utility of the sleep–wake classifier increased as it became a unimodal network only requiring respiratory input. This was achieved by using data augmentation during training. Sleep–wake prediction on “Test” using PSG respiration resulted in a Cohen’s kappa (κ) of 0.39 and using ccBioZ in κ = 0.23. The OSA risk model identified severe OSA patients with a κ of 0.61 for PSG respiration and κ of 0.39 using ccBioZ (accuracy of 80.6% and 69.4%, respectively). This study is one of the first to perform sleep–wake staging on capacitively-coupled respiratory signals in suspected OSA patients and to detect high risk OSA patients based on ccBioZ. The technology and the proposed framework could be applied in multi-night follow-up of OSA patients. Full article
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<p>Mattress with integrated capacitively-coupled sensors for acquisition of ccECG and ccBioZ.</p>
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<p>Pipeline of the study. The top blocks refer to the sections elaborating on the procedure below. The grey background blocks indicate the dataset used for model training and optimization. The black blocks at the bottom define the used test data. The data were first evaluated against PSG gold standard, then preprocessed and applied onto the original sleep–wake classifiers. Then, the RIP network was improved and merged with the ECG network. The augmented RIP CNN resulted in sleep–wake predictions, from which the percentage of uncertain predicted sleep epochs was derived, as well as the percentage of sleep stage transitions. These two indices were combined for OSA patient detection.</p>
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<p>Sleep–wake classifiers. (<b>A</b>) Unimodal network for cardiac input and (<b>B</b>) for respiratory input. (<b>C</b>) Multimodal network consisting of two branches. The left branch received tachograms and the right branch received respiratory waveforms.</p>
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<p>Results of ccECG evaluation when applying SQIs (high-quality data, HQ) and comparing against gold standard PSG ECG. The SQI algorithms are able to extract 21% of high-quality data for feature extraction. This is lower than in the previous data collection [<a href="#B10-sensors-21-06409" class="html-bibr">10</a>], presumably due to degradation of the ECG electrodes over time by usage and cleaning of the mattress. (<b>A</b>) Percentage of data used per patient after SQI processing. (<b>B</b>) Beat detection sensitivity before and after applying SQIs. (<b>C</b>) R-R Mean Absolute Error before and after applying SQIs. (<b>D</b>) Averaged tachogram correlation with gold standard before and after applying SQIs.</p>
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<p>Results of ccBioZ evaluation when applying SQIs (high-quality data, HQ) and comparing against gold standard PSG RIP. The increase in (<b>A</b>) percentage of ccBioZ classified as HQ in the current study is clear, when comparing to (<b>B</b>) the HQ ccBioZ data from a previous data collection [<a href="#B10-sensors-21-06409" class="html-bibr">10</a>]. (<b>C</b>,<b>D</b>) show the respiration rate error with and without SQI processing. (<b>E</b>) shows the average correlation between ccBioZ and gold standard RIP with and without SQI processing.</p>
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<p>The number of false wake predictions per total amount of true wake epochs after sleep–wake classification on the full ccBioZ recordings. A distinction was made between epochs without (white) and with apneas (grey).</p>
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<p>Application of the OSA patient detection model on the full ccBioZ recordings of the Test dataset. Circles represent AHI &lt; 15 and squares AHI ⩾ 15, and the lines are the index-specific thresholds. The model identified a patient as being at risk of OSA (AHI ⩾ 15) if <span class="html-italic">at least one of both</span> metrics exceeded a selected threshold (grey area). For this, the model yielded a specificity of 80%. Five of the detected patients exceeded the thresholds of <span class="html-italic">both</span> detection indices (red squares in upper right quadrant), who were identified as being at risk of OSA with 100% accuracy. On the other hand, two patients were falsely detected as being at risk of OSA, indicated as a green and yellow dot in the upper left quadrant.</p>
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17 pages, 2481 KiB  
Article
Noise-Reducing Fabric Electrode for ECG Measurement
by Takamasa Terada, Masahiro Toyoura, Takahide Sato and Xiaoyang Mao
Sensors 2021, 21(13), 4305; https://doi.org/10.3390/s21134305 - 23 Jun 2021
Cited by 8 | Viewed by 3519
Abstract
In this work, we propose a fabric electrode with a special structure that can play the role of a noise reduction filter. Fabric electrodes made of the conductive fabric have been used for long-term ECG measurements because of their flexibility and non-invasiveness; however, [...] Read more.
In this work, we propose a fabric electrode with a special structure that can play the role of a noise reduction filter. Fabric electrodes made of the conductive fabric have been used for long-term ECG measurements because of their flexibility and non-invasiveness; however, due to the large impedance between the skin and the fabric electrodes, noise is easily introduced into the ECG signal. In contrast to conventional work, in which chip-type passive elements are glued to the electrode to reduce noise, the proposed electrode can obtain a noise-reduced ECG by changing the structure of fabric. Specifically, the proposed electrode was folded multiple times to form a capacitor with a capacitance of about 3 nF. It is combined with the skin-electrode impedance to form a low-pass filter. In the experiment, we made a prototype of the electrodes and measured ECG at rest and during EMG-induced exercise. As a result, the SNR values at rest and during exercise were improved about 12.02 and 10.29 dB, respectively, compared with the fabric electrode without special structure. In conclusion, we have shown that changing the fabric electrode structure effectively removes noise in ECG measurement. Full article
(This article belongs to the Section Biomedical Sensors)
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<p>Relationship between the human body, skin-electrode interfaces, ECG measurement system, and noises. PLI, EMG and EM mean power line interference, electromyogram, and electrode motion, respectively.</p>
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<p>An overview of the proposed analog filter.</p>
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<p>The relationship of the impedance between each electrode.</p>
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<p>The impedance between the skin and the electrode.</p>
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<p>The simulation result changing <math display="inline"><semantics> <msub> <mi>R</mi> <mi>c</mi> </msub> </semantics></math>, <math display="inline"><semantics> <msub> <mi>C</mi> <mi>c</mi> </msub> </semantics></math>, and <math display="inline"><semantics> <msub> <mi>C</mi> <mi>e</mi> </msub> </semantics></math>.</p>
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<p>The structure of the fabric capacitor. (<b>a</b>) The conventional fabric such as pressure sensor. (<b>b</b>) The proposed fabric.</p>
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<p>The prototype of the proposed electrode. (<b>a</b>,<b>b</b>) show the top view and bottom view, respectively. The fabric capacitor consists of the vertical and the horizontal conductive fabric. The area connecting with the skin is <math display="inline"><semantics> <mrow> <mn>2</mn> <mo>×</mo> <mn>2</mn> </mrow> </semantics></math><math display="inline"><semantics> <mrow> <mi mathvariant="normal">c</mi> <msup> <mi mathvariant="normal">m</mi> <mn>2</mn> </msup> </mrow> </semantics></math>. To prevent skin touching the fabric capacitor, we used a non-conductive fabric in (<b>b</b>). The total thickness of the fabric electrode including that of a non-conductive fabric was about 1 <math display="inline"><semantics> <mi mathvariant="normal">c</mi> </semantics></math><math display="inline"><semantics> <mi mathvariant="normal">m</mi> </semantics></math>.</p>
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<p>The prototype of the proposed electrode. (<b>a</b>,<b>b</b>) show the top view and bottom view, respectively. The fabric capacitor consists of the vertical and the horizontal conductive fabric. The area connecting with the skin is <math display="inline"><semantics> <mrow> <mn>2</mn> <mo>×</mo> <mn>2</mn> </mrow> </semantics></math><math display="inline"><semantics> <mrow> <mi mathvariant="normal">c</mi> <msup> <mi mathvariant="normal">m</mi> <mn>2</mn> </msup> </mrow> </semantics></math>. To prevent skin touching the fabric capacitor, we used a non-conductive fabric in (<b>b</b>). The total thickness of the fabric electrode including that of a non-conductive fabric was about 1 <math display="inline"><semantics> <mi mathvariant="normal">c</mi> </semantics></math><math display="inline"><semantics> <mi mathvariant="normal">m</mi> </semantics></math>.</p>
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<p>The environment for measuring the capacitance of the electrode.</p>
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<p>Overview of the ECG measurement system. The system has three inputs from the right arm <math display="inline"><semantics> <msup> <mi mathvariant="normal">V</mi> <mo>−</mo> </msup> </semantics></math>, the left arm <math display="inline"><semantics> <msup> <mi mathvariant="normal">V</mi> <mo>+</mo> </msup> </semantics></math>, and the reference electrode <math display="inline"><semantics> <msub> <mi mathvariant="normal">V</mi> <mi>ref</mi> </msub> </semantics></math>. <math display="inline"><semantics> <msup> <mi mathvariant="normal">V</mi> <mo>−</mo> </msup> </semantics></math> and <math display="inline"><semantics> <msup> <mi mathvariant="normal">V</mi> <mo>+</mo> </msup> </semantics></math> are our proposed fabric electrodes, and <math display="inline"><semantics> <msub> <mi mathvariant="normal">V</mi> <mi>ref</mi> </msub> </semantics></math> is a non-folded fabric electrode. The ECG signal is sent to laptop via Bluetooth.</p>
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<p>The circuit for the ECG measurement. The red line indicates the proposed electrode. The circuit consists of the twin-t notch filter, the first order high-pass filter and the amplifiers.</p>
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<p>The ECG measurement result using the non-folded fabric electrode at rest. (<b>a</b>) The measured signal and the signal filtered by FIR filters. (<b>b</b>) The high-frequency component above 100 <math display="inline"><semantics> <mi>Hz</mi> </semantics></math> in (<b>a</b>). (<b>a</b>,<b>b</b>) are the common in <a href="#sensors-21-04305-f012" class="html-fig">Figure 12</a>, <a href="#sensors-21-04305-f013" class="html-fig">Figure 13</a> and <a href="#sensors-21-04305-f014" class="html-fig">Figure 14</a>.</p>
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<p>The ECG measurement result using the proposed fabric electrode at rest.</p>
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<p>The ECG measurement result using the non-folded fabric electrode in exercise.</p>
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<p>The ECG measurement result using the proposed fabric electrode in exercise.</p>
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<p>The power spectral density.</p>
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<p>ECG template for each electrode. (<b>a</b>) At rest, (<b>b</b>) during exercise.</p>
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23 pages, 2776 KiB  
Article
Dedicated Algorithm for Unobtrusive Fetal Heart Rate Monitoring Using Multiple Dry Electrodes
by Alessandra Galli, Elisabetta Peri, Yijing Zhang, Rik Vullings, Myrthe van der Ven, Giada Giorgi, Sotir Ouzounov, Pieter J. A. Harpe and Massimo Mischi
Sensors 2021, 21(13), 4298; https://doi.org/10.3390/s21134298 - 23 Jun 2021
Cited by 13 | Viewed by 3465
Abstract
Multi-channel measurements from the maternal abdomen acquired by means of dry electrodes can be employed to promote long-term monitoring of fetal heart rate (fHR). The signals acquired with this type of electrode have a lower signal-to-noise ratio and different artifacts compared to signals [...] Read more.
Multi-channel measurements from the maternal abdomen acquired by means of dry electrodes can be employed to promote long-term monitoring of fetal heart rate (fHR). The signals acquired with this type of electrode have a lower signal-to-noise ratio and different artifacts compared to signals acquired with conventional wet electrodes. Therefore, starting from the benchmark algorithm with the best performance for fHR estimation proposed by Varanini et al., we propose a new method specifically designed to remove artifacts typical of dry-electrode recordings. To test the algorithm, experimental textile electrodes were employed that produce artifacts typical of dry and capacitive electrodes. The proposed solution is based on a hybrid (hardware and software) pre-processing step designed specifically to remove the disturbing component typical of signals acquired with these electrodes (triboelectricity artifacts and amplitude modulations). The following main processing steps consist of the removal of the maternal ECG by blind source separation, the enhancement of the fetal ECG and identification of the fetal QRS complexes. Main processing is designed to be robust to the high-amplitude motion artifacts that corrupt the acquisition. The obtained denoising system was compared with the benchmark algorithm both on semi-simulated and on real data. The performance, quantified by means of sensitivity, F1-score and root-mean-square error metrics, outperforms the performance obtained with the original method available in the literature. This result proves that the design of a dedicated processing system based on the signal characteristics is necessary for reliable and accurate estimation of the fHR using dry, textile electrodes. Full article
(This article belongs to the Special Issue Sensors and Biomedical Signal Processing for Patient Monitoring)
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<p>Features of the employed acquisition system. (<b>a</b>) Placement of electrodes by means of elastic belts on the mother’s belly. (<b>b</b>) Four textile electrodes. (<b>c</b>) Schematic configuration of the electrodes and the related bipolar leads, which are identified by arrows. The configuration is symmetric with respect to the navel.</p>
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<p>Comparison between the proposed approach and VA. Hybrid (hardware and software) pre-processing consists of the removal of triboelectricity artifacts, filtering, and amplitude demodulation and was introduced in the proposed approach to managing the artifacts typical of signals acquired with dry electrodes. Main-processing consists of three steps, which are the same as in VA, improved to guarantee robustness against artifacts. In the three lower blocks, the details of each step are reported both for VA and the proposed approach. In red, the modifications introduced are reported, and in blue, the stages that remain unchanged are reported.</p>
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<p>(<b>a</b>) Example of a channel acquired without reset. (<b>b</b>) Example of a channel acquired with reset. (<b>c</b>) Influence of the reset artifact on the signal. The plot above shows the acquired signal; at <math display="inline"><semantics> <mrow> <mi>t</mi> <mo>=</mo> <mn>17</mn> </mrow> </semantics></math> there is a step due to the reset. The signal after filtering if the step is removed is shown in the middle. The plot on the bottom shows the filtered signal if the step is not removed.</p>
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<p>Block diagram of the hardware system employed in this project.</p>
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<p>(<b>a</b>) Raw signals (black) affected by the amplitude modulation and the positive and the negative envelops (grey). (<b>b</b>) How the related signals appear after the compensation of the modulation.</p>
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<p>Block diagram of the steps (mQRS detection, mECG canceling and fHR estimation) of the main processing stage. The input is the matrix <math display="inline"><semantics> <mi mathvariant="bold">Y</mi> </semantics></math>, which contains the bipolar measurements obtained after the pre-processing stage. The output is the fHR estimation. For the yellow blocks, only 1 element is involved; on the contrary, for the green blocks, all the elements are involved.</p>
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<p>The main independent components obtained after the first ICA and the mQRS (black dots) detected for each component.</p>
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<p>(<b>a</b>,<b>b</b>) Aligned segments employed for SVD decomposition and the related obtained template (black). (<b>a</b>) Approximation of the cardiac cycle is wrong due to the presence of high artifacts. (<b>b</b>) The estimation is correct by discarding the segments with artifacts. (<b>c</b>,<b>d</b>) Comparison between the independent components obtained by ICA (grey), the mECG estimated (black dash-dot) and the resulting signals after the canceling (black). (<b>c</b>) Canceling with VA, part of the mECG is not correctly removed. (<b>d</b>) Employing the proposed approach, the mECG is effectively removed.</p>
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<p>Signal segmentation scheme for the last step of the fHR estimation algorithm.</p>
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<p>Examples of outcomes on DS-PN. Comparison of the fHR estimation with VA (upper) and the proposed method (lower), the reference is the gray line. (<b>a</b>) Record a19. (<b>b</b>) Record a34.</p>
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<p>Examples of outcomes on DS-SS. Comparison of the fHR estimation with VA (<b>upper</b>) and the proposed method, (<b>lower</b>) the reference is the gray line.</p>
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<p>Boxplot of the results obtained on the DS-PN and DS-SS with VA and the proposed methods. (<b>a</b>) F1-score (<b>b</b>) RMSE.</p>
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<p>Boxplot of the results obtained on the DS-PN and DS-SS with VA and the proposed methods. (<b>a</b>) F1-score (<b>b</b>) RMSE.</p>
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<p>Examples of outcomes on DS-R. Comparison of fHR (dot) and mHR (line) estimation by VA and by the proposed method (upper and lower, respectively). (<b>a</b>) Real Acquisition 1. (<b>b</b>) Real Acquisition 2. (<b>c</b>) Real Acquisition 3.</p>
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<p>Examples of outcomes on DS-R. Comparison of fHR (dot) and mHR (line) estimation by VA and by the proposed method (upper and lower, respectively). (<b>a</b>) Real Acquisition 1. (<b>b</b>) Real Acquisition 2. (<b>c</b>) Real Acquisition 3.</p>
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24 pages, 4177 KiB  
Review
Wearable Smart Textiles for Long-Term Electrocardiography Monitoring—A Review
by Abreha Bayrau Nigusse, Desalegn Alemu Mengistie, Benny Malengier, Granch Berhe Tseghai and Lieva Van Langenhove
Sensors 2021, 21(12), 4174; https://doi.org/10.3390/s21124174 - 17 Jun 2021
Cited by 69 | Viewed by 11954
Abstract
The continuous and long-term measurement and monitoring of physiological signals such as electrocardiography (ECG) are very important for the early detection and treatment of heart disorders at an early stage prior to a serious condition occurring. The increasing demand for the continuous monitoring [...] Read more.
The continuous and long-term measurement and monitoring of physiological signals such as electrocardiography (ECG) are very important for the early detection and treatment of heart disorders at an early stage prior to a serious condition occurring. The increasing demand for the continuous monitoring of the ECG signal needs the rapid development of wearable electronic technology. During wearable ECG monitoring, the electrodes are the main components that affect the signal quality and comfort of the user. This review assesses the application of textile electrodes for ECG monitoring from the fundamentals to the latest developments and prospects for their future fate. The fabrication techniques of textile electrodes and their performance in terms of skin–electrode contact impedance, motion artifacts and signal quality are also reviewed and discussed. Textile electrodes can be fabricated by integrating thin metal fiber during the manufacturing stage of textile products or by coating textiles with conductive materials like metal inks, carbon materials, or conductive polymers. The review also discusses how textile electrodes for ECG function via direct skin contact or via a non-contact capacitive coupling. Finally, the current intensive and promising research towards finding textile-based ECG electrodes with better comfort and signal quality in the fields of textile, material, medical and electrical engineering are presented as a perspective. Full article
(This article belongs to the Special Issue Textile Sensors Based on Printed Electronics Technology)
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<p>(<b>a</b>) Typical normal ECG signal with major components from Lead I configuration; (<b>b</b>) electrode placement for standard clinical ECG measurement, where V is the voltage, RA is the right arm, LA is the left arm, RL is the right leg, and LL is the left leg electrodes.</p>
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<p>Schematic representation of: (<b>a</b>) ideal non-polarizing electrode; (<b>b</b>) ideal polarizing electrode.</p>
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<p>ECG electrodes with skin side (left) and snap side (right): (<b>a</b>) Ag/AgCl; (<b>b</b>) orbital with 150 µm pins; and (<b>c</b>) stainless steel electrode. Adopted from [<a href="#B47-sensors-21-04174" class="html-bibr">47</a>].</p>
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<p>Non-contact metal integrated textile electrodes and typical results: (<b>a</b>) textile electrodes integrated into a wheelchair [<a href="#B75-sensors-21-04174" class="html-bibr">75</a>]; (<b>b</b>) smart mattress with textile electrodes, adopted from [<a href="#B71-sensors-21-04174" class="html-bibr">71</a>]; (<b>c</b>) a person wearing a strap with an ECG sensor (a foam coated with Ni/Cu) around the lower chest over her t-shirt, adapted from [<a href="#B67-sensors-21-04174" class="html-bibr">67</a>]; (<b>d</b>) normalized ECG waveforms measured from Ag/AgCl electrodes (red line) and capacitive textile electrodes (blue line), adapted from [<a href="#B71-sensors-21-04174" class="html-bibr">71</a>].</p>
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<p>Examples of metal-coated textile-based ECG electrodes and resulting signal; (<b>a</b>) interior side of the silver-coated textile electrode, adopted from [<a href="#B74-sensors-21-04174" class="html-bibr">74</a>]; (<b>b</b>) structure of a textile electrode and connection track, adopted from [<a href="#B81-sensors-21-04174" class="html-bibr">81</a>]; (<b>c</b>) textile electrode developed by sewing silver thread onto fabric, adopted from [<a href="#B88-sensors-21-04174" class="html-bibr">88</a>]; and (<b>d</b>) comparison of ECG signals from a T-shirt with silver-plated active textile electrodes (blue) bandpass filtered (2–20 Hz) and reference Ag/AgCl electrode (red), adapted from [<a href="#B74-sensors-21-04174" class="html-bibr">74</a>].</p>
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<p>Examples of graphene-coated textile ECG electrodes and resulting signals: (<b>a</b>) photograph of a sample grapheme-clad nylon fabric for ECG electrode, adopted from [<a href="#B63-sensors-21-04174" class="html-bibr">63</a>]; (<b>b</b>) graphene-coated polyester fiber electrode, adopted from [<a href="#B25-sensors-21-04174" class="html-bibr">25</a>]; (<b>c</b>) ECG signals recorded from conventional Ag/AgCl electrodes and the graphene-clad textile with wristband, adopted from [<a href="#B39-sensors-21-04174" class="html-bibr">39</a>]; and (<b>d</b>) filtered ECG signals from Ag/AgCl and graphene-clad textile electrodes, adopted from [<a href="#B63-sensors-21-04174" class="html-bibr">63</a>].</p>
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<p>Conductive polymer-coated textile electrodes: (<b>a</b>) PEDOT:PSS and ionic liquid gel-coated polyester textile electrode, adopted from [<a href="#B23-sensors-21-04174" class="html-bibr">23</a>]; (<b>b</b>) PEDOT:PSS-coated textile electrode, adopted from [<a href="#B96-sensors-21-04174" class="html-bibr">96</a>]; (<b>c</b>) ECG signal collected from PEDOT:PSS-coated textile electrode before washing; and (<b>d</b>) after 50 washing cycle, adopted from [<a href="#B92-sensors-21-04174" class="html-bibr">92</a>]. The ECG signals collected using textile electrodes show 25.5 dB SNR before washing and 10.3 dB SNR after 50 washing cycles.</p>
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<p>ECG recordings performed with the PEDOT:PSS/IL textile electrode (in blue), and Ag/AgCl electrode (in red): (<b>a</b>) from volunteers sitting at rest; (<b>b</b>) during movement; (<b>c</b>) percentage of the accuracy of heartbeat detection during different types of activity (seating, standing up, leg moving, arm moving, walking) with textile and Ag/AgCl electrodes; and (<b>d</b>) ECG signal evolutions obtained with textile electrodes in permanent contact with the skin over three days. The inset shows a picture of the skin under the electrode after 72 h. The last ECG signals were obtained from re-used textile electrodes stored in ambient air for one month, adopted from [<a href="#B23-sensors-21-04174" class="html-bibr">23</a>].</p>
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<p>Different wearable textile ECG monitoring systems: (<b>a</b>) ECG T-shirt with active electrodes and connectors, adapted from [<a href="#B74-sensors-21-04174" class="html-bibr">74</a>]; (<b>b</b>) PEDOT:PSS-coated polyamide electrodes sewn into bras, adopted from [<a href="#B24-sensors-21-04174" class="html-bibr">24</a>]; (<b>c</b>) electrode placement for ECG measurement where plastic clamps were used to fix the electrodes onto the wrist, adopted from [<a href="#B92-sensors-21-04174" class="html-bibr">92</a>]; (<b>d</b>) ECG sensing wristband with printed and flexible electrodes, adapted from [<a href="#B91-sensors-21-04174" class="html-bibr">91</a>]; (<b>e</b>) wearable chest belt with silver-coated nylon woven electrodes and Bluetooth module, adopted from [<a href="#B123-sensors-21-04174" class="html-bibr">123</a>]; (<b>f</b>) ECG belt with wetting pad (above) and the embroidered electrodes (below), adopted from [<a href="#B103-sensors-21-04174" class="html-bibr">103</a>].</p>
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<p>Different wearable textile ECG monitoring systems: (<b>a</b>) ECG T-shirt with active electrodes and connectors, adapted from [<a href="#B74-sensors-21-04174" class="html-bibr">74</a>]; (<b>b</b>) PEDOT:PSS-coated polyamide electrodes sewn into bras, adopted from [<a href="#B24-sensors-21-04174" class="html-bibr">24</a>]; (<b>c</b>) electrode placement for ECG measurement where plastic clamps were used to fix the electrodes onto the wrist, adopted from [<a href="#B92-sensors-21-04174" class="html-bibr">92</a>]; (<b>d</b>) ECG sensing wristband with printed and flexible electrodes, adapted from [<a href="#B91-sensors-21-04174" class="html-bibr">91</a>]; (<b>e</b>) wearable chest belt with silver-coated nylon woven electrodes and Bluetooth module, adopted from [<a href="#B123-sensors-21-04174" class="html-bibr">123</a>]; (<b>f</b>) ECG belt with wetting pad (above) and the embroidered electrodes (below), adopted from [<a href="#B103-sensors-21-04174" class="html-bibr">103</a>].</p>
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<p>The progress of reports on textile-based ECG electrodes according to Web of Science core collections.</p>
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21 pages, 11706 KiB  
Article
Novel Stable Capacitive Electrocardiogram Measurement System
by Chi-Chun Chen, Shu-Yu Lin and Wen-Ying Chang
Sensors 2021, 21(11), 3668; https://doi.org/10.3390/s21113668 - 25 May 2021
Cited by 8 | Viewed by 4552
Abstract
This study presents a noncontact electrocardiogram (ECG) measurement system to replace conventional ECG electrode pads during ECG measurement. The proposed noncontact electrode design comprises a surface guard ring, the optimal input resistance, a ground guard ring, and an optimal voltage divider feedback. The [...] Read more.
This study presents a noncontact electrocardiogram (ECG) measurement system to replace conventional ECG electrode pads during ECG measurement. The proposed noncontact electrode design comprises a surface guard ring, the optimal input resistance, a ground guard ring, and an optimal voltage divider feedback. The surface and ground guard rings are used to reduce environmental noise. The optimal input resistor mitigates distortion caused by the input bias current, and the optimal voltage divider feedback increases the gain. Simulated gain analysis was subsequently performed to determine the most suitable parameters for the design, and the system was combined with a capacitive driven right leg circuit to reduce common-mode interference. The present study simulated actual environments in which interference is present in capacitive ECG signal measurement. Both in the case of environmental interference and motion artifact interference, relative to capacitive ECG electrodes, the proposed electrodes measured ECG signals with greater stability. In terms of R–R intervals, the measured ECG signals exhibited a 98.6% similarity to ECGs measured using contact ECG systems. The proposed noncontact ECG measurement system based on capacitive sensing is applicable for use in everyday life. Full article
(This article belongs to the Special Issue Advances in ECG Sensing and Monitoring)
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<p>Active capacitive electrode design. (<b>a</b>) Active electrode equivalent circuit and (<b>b</b>) pictures of the active capacitive electrode.</p>
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<p>Effect of different resistance values (<span class="html-italic">R<sub>load</sub></span>) on gain (V<sub>out</sub>/V<sub>i</sub>). (<b>a</b>) Effect of resistance values between 100 MΩ and 100 GΩ on gain; (<b>b</b>) effect of resistance values between 100 MΩ and 100 GΩ on gain ratio at 60 Hz.</p>
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<p>Effect of output divider feedback on gain. (<b>a</b>) Effect of a 0.02–40.01 (<span class="html-italic">R<sub>fl</sub></span> + <span class="html-italic">R<sub>fh</sub></span>)/<span class="html-italic">R<sub>fl</sub></span> ratio on gain; (<b>b</b>) effect of 1 MΩ to 1 GΩ <span class="html-italic">R<sub>fl</sub></span> values on gain.</p>
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<p>Effect of output divider feedback on gain. (<b>a</b>) Effect of a 0.02–40.01 (<span class="html-italic">R<sub>fl</sub></span> + <span class="html-italic">R<sub>fh</sub></span>)/<span class="html-italic">R<sub>fl</sub></span> ratio on gain; (<b>b</b>) effect of 1 MΩ to 1 GΩ <span class="html-italic">R<sub>fl</sub></span> values on gain.</p>
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<p>Design of the noncontact ECG measurement circuit.</p>
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<p>Back-end signal processing and amplifier circuit.</p>
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<p>Classic electrode equivalent circuit.</p>
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<p>Simulated measurement system.</p>
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<p>Human measurement system development.</p>
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<p>Signals measured when the forward- and backward-moving interference moved at distances of (<b>a</b>) 70–50 cm, (<b>b</b>) 50–25 cm, and (<b>c</b>) 25–0 cm in front of the electrode.</p>
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<p>Signals measured when left- and right-moving interference was positioned (<b>a</b>) 75 cm, (<b>b</b>) 50 cm, and (<b>c</b>) 25 cm in front of the electrode.</p>
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<p>Signals measured when left- and right-moving interference was positioned (<b>a</b>) 75 cm, (<b>b</b>) 50 cm, and (<b>c</b>) 25 cm in front of the electrode.</p>
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<p>Signals measured when the interferer moved left and right at distances of. (<b>a</b>) 75 cm, (<b>b</b>) 50 cm, and (<b>c</b>) 25 cm at the sides of the electrode.</p>
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<p>Signals measured when the interferer moved left and right at distances of. (<b>a</b>) 75 cm, (<b>b</b>) 50 cm, and (<b>c</b>) 25 cm at the sides of the electrode.</p>
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<p>Signal-to-noise ratio (SNR) comparison of interference at different distances.</p>
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<p>Signals measured when forward- and backward-moving interferers moved at distances of (<b>a</b>) 75–50, (<b>b</b>) 50–25, and (<b>c</b>) 25–0 cm in front of the participant.</p>
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<p>Signals measured when forward- and backward-moving interferers moved at distances of (<b>a</b>) 75–50, (<b>b</b>) 50–25, and (<b>c</b>) 25–0 cm in front of the participant.</p>
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<p>Signals measured when a left- and right-moving interferers were positioned (<b>a</b>) 75, (<b>b</b>) 50, and (<b>c</b>) 25 cm in front of the participant.</p>
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<p>Signals measured when a left- and right-moving interferer was (<b>a</b>) 75, (<b>b</b>) 50, and (<b>c</b>) 25 cm to the sides of the participant.</p>
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<p>Signals measured under motion artifact interference generated by the participant’s (<b>a</b>) forward and backward and (<b>b</b>) left and right body movements.</p>
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<p>Comparison between the interference at 15–45 s during ECG signal measurement by the (<b>a</b>) conventional contact electrode, (<b>b</b>) proposed CECG electrode, and (<b>c</b>) classic CECG electrode.</p>
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