Search Results (235,007)

Recent advancements in polymer materials have enabled the synthesis of bio-based monomers from renewable resources, promoting sustainable alternatives to fossil-based materials. This study presents a novel zwitterionic surfactant, SF, derived from 10-undecenoic acid obtained from castor oil through a four-step reaction, achieving a yield of 78%. SF has a critical micelle concentration (CMC) of 1235 mg/L, slightly higher than the commercial anionic surfactant Rhodacal DS-4 (sodium dodecyl benzene sulfonate), and effectively stabilizes monomer droplets, leading to excellent conversion and stable latex formation. The zwitterionic groups in SF enhance adhesion to hydrophilic substrates (glass, stainless steel, and skin). Films produced with SF exhibit outstanding water resistance, with only 18.48% water uptake after 1800 min, compared to 81% for the control using Rhodacal DS-4. Notably, SF maintains low water uptake across various concentrations, minimizing water penetration. Thus, the synthesized SF demonstrates improved adhesive properties and excellent water resistance in emulsion polymerization applications, highlighting its potential as a sustainable, high-performance alternative to petrochemical surfactants. Full article

One of the most challenging aspects of manipulating the flow of fluids in subsurfaces is to control their flow direction and flow behavior. This can be especially challenging for compressible fluids, such as CO₂, and for multiphase flow, including both water and carbon dioxide (CO₂). This research studies the ability of two crosslinked polymers, including hydrolyzed polyacrylamide and acrylic acid/hydrolyzed polyacrylamide crosslinked polymers, to reduce the permeability of both CO₂ and formation water using different salinities and permeability values and in the presence of crude oil under different injection rates. The result showed that both polymers managed to reduce the permeability of water effectively; however, their CO₂ permeability-reduction potential was much lower, with the CO₂ permeability reduction being less than 50% of the water reduction potential in the majority of the experiments. This was mainly due to the high flow rate of the CO₂ compared to the water, which resulted in significant shearing of the crosslinked polymer. The crosslinked polymers’ swelling ratios were impacted differently based on the salinity, with the maximum swelling ratio being 9.8. The HPAM polymer was negatively affected by the presence of crude oil, whereas increasing salinity improved its performance greatly. All in all, both polymers had a higher permeability reduction for the formation water compared to CO₂ under all conditions. This research can help improve the applicability of CO₂-enhanced oil recovery and CO₂ storage in depleted oil reservoirs. The ability of the crosslinked polymers to improve CO₂ storage will be a main focus of future research. Full article

This work compares two technologies for the remediation of metal-polluted mine tailings based on lab-scale bioleaching experiments performed in (a) conventional agitated slurry-phase reactors and (b) in situ electrokinetic percolation. While ex situ bioleaching in agitated reactors has been widely studied, only a few previous works have studied the in situ option that couples bioleaching and electrokinetics. Real mine tailings from an abandoned sphalerite mine in southern Spain were used. The leaching medium was externally generated in a bioreactor using an autochthonous acidophilic culture and then added to tailings in batch experiments. This medium enabled metal leaching from mine tailings without the stringent operating conditions required by a classic bioleaching process. Metal removal efficiencies and kinetic rate constants after 15 d of treatments were calculated. Additionally, advantages or disadvantages between the two methods were discussed. The results for the innovative EK-percolation method showed rates and efficiencies that were comparable to, and in some cases better than, those achieved with conventional stirred slurry systems. Full article

In this study, molecular dynamics simulations were employed to analyze interactions between phospholipid membranes and human serum albumin (HSA) in the presence of mono- and divalent cations. Two types of membranes, composed of dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidylethanolamine (DPPE), were utilized. The results revealed that both systems exhibited high stability. The DPPE complexes displayed a greater affinity for albumin compared to DPPC. The high stability of the complexes was attributed to a high number of ionic contacts and hydrogen bonds. The presence of mono- and divalent metal cations significantly influenced the membrane’s capacity to bind proteins. However, these effects varied depending on the phospholipid composition of the bilayer. The studies confirmed the relatively low ability of DPPC to bind potassium ions, as previously observed by others. Consequently, the DPPC/HSA/K⁺ complex was found to be the least stable among the systems studied. While DPPC interactions were limited to HSA domains I and II, DPPE was able to interact with all domains of the protein. Both lipid bilayers exhibited substantial structural changes and characteristic curvature induced by interactions with HSA, which confirms the formation of relatively strong interactions capable of influencing the arrangement of the phospholipids. Full article

The Banks grass mite/New World date mite, Oligonychus pratensis (Banks) (Acari: Prostigmata: Tetranychidae), is a globally distributed and economically significant agricultural pest. The present study comprehensively addresses the morphotaxonomic identification of globally reported populations of O. pratensis, to resolve ambiguities within the pratensis complex. Detailed morphological characterizations of all mobile stages (larva, protonymph, deutonymph, male, and female) of the Californian population of O. pratensis were provided, with key diagnostic traits utilized in this taxonomic assessment. The taxonomic notes are provided for worldwide populations of O. pratensis reported from six biogeographic realms. The taxonomic identity of the claimed populations of O. pratensis from South Africa (Afrotropical realm), El Salvador (Neotropical realm), China, Pakistan (Oriental realm), and Saudi Arabia (Palearctic realm) were found to either be “doubtful” or exhibit notable differences compared to the Californian population. Notably, the purported Chinese population of O. pratensis was identified as a cryptic species, likely a novel taxon within the gossypii species subgroup. Furthermore, the study confirmed the absence of O. pratensis in Saudi Arabia. Additionally, ontogenetic changes across developmental stages are documented. The findings of this study may contribute to a clearer understanding of the true distribution and global occurrence of O. pratensis, providing robust diagnostic characteristics to support future research. Full article

Topical formulations that include natural active compounds to treat inflamed and aching skin are favored by patients. Small local producers use commercial creams and gels to which they add compounds, often with criteria based more on trends than scientific evidence, to obtain products to treat inflamed joints or skin. Based on our previous studies that demonstrated the anti-inflammatory and analgesic effects of Harpagophytum procumbens extracts and N-acetylglucosamine, we were interested in preparing formulations with these natural substances for topical applications. In the present study, we compared the rheological properties of various creams and gels with bulk and nanoparticle forms of N-acetylglucosamine added, focusing on the flow properties of multiphase emulsion. Moreover, the ability of nanoparticles to reduce inflammation and stimulate collagen production was demonstrated in both chondrocyte and fibroblast spheroids. The results showed the activity of nano-N-acetylglucosamine in our cell models, suggesting its suitability for use as a component in creams and gels. Furthermore, its ability to affect the flow properties of commercial creams and gels makes it an ideal component of topical formulations for the treatment of inflamed skin and joints. Full article

The total control of major water pollutants (TCMWP) is a critical strategy for improving water quality in China, with the added benefit of yielding climate-related advantages. This study uses the emission factor method to quantify the reductions in pollutants and carbon emissions resulting from China’s implementation of TCMWP. A synergy scale for pollution and carbon reduction was constructed to assess the co-benefits of reducing the Chemical Oxygen Demand (COD) and ammonium nitrogen (NH₄⁺-N) and carbon dioxide (CO₂) emissions. Furthermore, to account for regional variations in energy structure regulation strategies, whether aggressive or unified, we developed Pollutant Synergistic Carbon Reduction Pathways at the Regional (R.PSCRP) model framework level to evaluate the carbon emission reduction potential of TCMWP during the “14th Five-Year Plan” period. The study revealed that China’s unified TCMWP employs different but highly effective combinations of emission reduction paths across different regions. Notably, new renovations and expansions of wastewater treatment facilities (NRE-WWTFS) and pipeline network construction and renovation (CR-PNK) together accounted for 89.3% of the total emission reduction. The construction of key water pollutant reduction projects plays a significant role in reducing carbon emissions at the district level compared to direct discharge practices. Additionally, indirect emissions resulting from TCMWP implementation account for approximately 50% of the total carbon reduction achieved. By aligning either harmonized or independent energy adjustment targets, regions were able to achieve substantial pollution and carbon reduction benefits, ranging from 7.5 to 8 million tons of CO₂-equivalent. Full article

This study aims to optimize the thermal performance of pin fin heat sinks by minimizing the maximum temperature of the heat source. Using ANSYS ICEPAK, simulations were conducted for various design parameters, including the number of fins, inlet flow rate, and fin thickness, across circular fins in both inline and staggered arrangements. The circular staggered configuration with 36 fins (3 mm thick) and a flow rate of 6 CFM (Cubic Feet per Minute) achieved the lowest temperature of 34.96 °C, outperforming the inline arrangement. The Taguchi method helped strike a balance between heat transfer and pressure drop, revealing that flow rate has a greater influence when varied compared to the number of fins and fin thickness. An optimal configuration was identified with 36 fins and a flow rate of 4 CFM, which was less sensitive to operational variations. Analysis of Variance (ANOVA) revealed that inlet flow rate significantly impacts heat sink performance, while polynomial regression models demonstrated strong generalization capabilities, with Root mean square error (RMSE) of 8.92%. These findings provide reliable predictive tools and practical insights for optimizing heat sink designs in electronics cooling applications. By utilizing the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method, the coefficient of relative closeness (Cn*) is plotted as a main effect. Referring to the multi-objective optimization-based TOPSIS method, it is found that the attributes are partly from the inlet flow rate (Q) are 63.4% of the number of fins (Nf) (25.05%). Full article

: Objectives: To determine whether a closed dressing protocol reduces the surgical site infections (SSI) rate compared to conventional closing techniques. Methods: Patients who underwent lumbar spine surgery at two neurosurgical centers were retrospectively included from June 2015 to December 2019. Data on patients, general risk factors, and surgical risk factors for SSI were collected. Patients were subdivided into two groups: a Closed Protocol where the Dermabond^® ± Prineo^® dressing system was used, and a Conventional Protocol, namely sutures or staples. Statistical analysis was undertaken to compare the infection rates among the different closure techniques. Results: Altogether, 672 patients were included. In the whole cohort, 157 (23.36%) underwent skin closure with staples, 122 (18.15%) with sutures, 98 (14.58%) with intracutaneous sutures, 78 (11.61%) with Dermabond^®, and 217 (32.29%) with Demabond^® + Prineo^®. The overall infection rate was 2.23% (n = 15). Skin suture had the highest infection rate (4.10%), while the lowest was Dermabond^® (1.28%) and Dermabond^® + Prineo^® (1.4%), though the difference was not significant. Risk factors for SSI included higher BMI (29.46 kg/m² vs. 26.96 kg/m², p = 0.044), other sites infection (20.00% vs. 2.38%, p = 0.004), and a higher national nosocomial infections surveillance score (p = 0.003). Conclusions: This study showed that a closed protocol with the use of adhesive dressing with or without mesh had a slight tendency to lower infection rates compared to conventional protocol with sutures or staples, although no statistically significant difference was found between the closure techniques. Larger randomized studies are needed to investigate this potential benefit avoiding selection bias. Full article

The rising demand for building cooling has led to increased energy consumption and environmental concerns. This study aims to examine the effectiveness of natural ventilation strategies as sustainable approaches in arid and semi-arid climates, focusing on Kabul City. Employing integrated simulation techniques, including annual energy simulation and Computational Fluid Dynamics (CFD) analysis, various ventilation approaches were evaluated, such as single-side ventilation, cross-ventilation, and windcatchers. Results indicate that cross-ventilation with opposing windows significantly outperformed other strategies in terms of natural ventilation rates, achieving a 62.5% improvement over single-sided ventilation and a 36% improvement over cross-ventilation with adjacent windows. However, the complex interplay between solar gain and natural ventilation in these climates can lead to increased cooling demand. To address this challenge, integrating south-(S)-facing orientations into both single-sided and cross-ventilated configurations was found to be a balanced and effective approach. These scenarios demonstrated significant total energy savings. Among single-sided ventilation, the S-facing scenario achieved an average of 58.3% energy savings. For opposing cross-ventilation, the north-south (NS) scenario yielded 65.6% energy savings. Finally, adjacent cross-ventilation in the east-south (ES) and south-west (SW) scenarios resulted in an average of 51% energy savings. Furthermore, windcatchers, when combined with single-sided ventilation, further enhanced natural ventilation and reduced cooling demand while maintaining nearly consistent heating demand. Optimized rooftop windcatchers improved natural ventilation rates by up to 26.9% and attached windcatchers achieved up to 56.8% improvement. Compared to a baseline, rooftop windcatchers reduced cooling demand by 6.2%, and attached windcatchers by up to 18.7%. The findings of this study highlight the potential of window-based and windcatcher natural ventilation strategies as energy-efficient and balanced approaches for reducing building energy consumption, particularly cooling loads, in arid and semi-arid climates. These insights provide valuable guidance for architects and policymakers seeking to promote sustainable and energy-efficient building practices. Full article

Natural aging and age-related diseases involve the acceleration of replicative aging, or senescence. Multiple proteins are known to participate in these processes, including the promyelocytic leukemia (PML) protein, which serves as a core component of nuclear-membrane-less organelles known as PML nuclear bodies (PML-NBs). In this work, morphological changes in PML-NBs and alterations in PML protein localization at the transition of primary fibroblasts to a replicative senescent state were studied by immunofluorescence. The fibroblasts were obtained from both healthy donors and donors with premature aging syndromes (ataxia-telangiectasia and Cockayne syndrome). Our data showed an increase in both the size and the number of PML-NBs, along with nuclear enlargement in senescent cells, suggesting these changes could serve as potential cellular aging markers. Bioinformatic analysis demonstrated that 30% of the proteins in the PML interactome and ~45% of the proteins in the PML-NB predicted proteome are directly associated with senescence and aging processes. These proteins are hypothesized to participate in post-translational modifications and protein sequestration within PML-NBs, thereby influencing transcription factor regulation, DNA damage response, and negative regulation of apoptosis. The findings confirm the significant role of PML-NBs in cellular aging processes and open new avenues for investigating senescence mechanisms and age-associated diseases. Full article

Background: Treatments that combine both elastic and rigid taping in knee osteoarthritis have not yet been investigated in the literature. Thus, the purpose of the present study is to investigate how the combination taping technique affects functional status, disability, and quadricep isokinetic torque in cases of knee osteoarthritis. Patient Methods: A total of fifty-four patients were assigned to the experimental group or control group. Conventional physical therapy was provided to both groups, in addition, participants in the experimental group also received combination taping. Disability, functional status, and isokinetic quadriceps torque were assessed at baseline, six weeks (post-intervention), and twelve weeks (follow-up). Results: MANOVA showed that post-intervention measurements were significantly better than baseline measurements of both groups, except for isokinetic quadriceps torque, which showed a nonsignificant difference in the control group. The control group’s follow-up measurements revealed nonsignificant differences from those taken after the intervention, whereas the experimental group’s differences were significant excluding isokinetic quadriceps torque. Measurements taken at post-intervention and follow-up revealed that the experimental group had significantly improved compared to the control groups. Conclusion: Combination taping was found to be more beneficial when used in addition to conventional physical therapy than when used alone in knee OA. Full article

This review aims to examine existing research on the development of ocular drug delivery devices utilizing hyaluronic acid (HA). Renowned for its exceptional biocompatibility, viscoelastic properties, and ability to enhance drug bioavailability, HA is a naturally occurring biopolymer. The review discussed specific mechanisms by which HA enhances drug delivery, including prolonging drug residence time on ocular surfaces, facilitating controlled drug release, and improving drug penetration through ocular tissues. By focusing on these unique functionalities, this review highlights the potential of HA-based systems to revolutionize ocular treatment. Various fabrication techniques for HA-based ocular drug delivery systems, including hydrogels, nanoparticles, and microneedles, are discussed, highlighting their respective advantages and limitations. Additionally, this review explores the clinical applications of HA-based devices in treating a range of ocular diseases, such as dry eye syndrome, glaucoma, retinal disorders, and ocular infections. By comparing the efficacy and safety profiles of these devices with traditional ocular drug delivery methods, this review aims to provide a comprehensive understanding of the potential benefits and challenges associated with HA-based systems. Moreover, this review discusses current limitations and future directions in the field, such as the need for standardized fabrication protocols, long-term biocompatibility studies, and large-scale clinical trials. The insights and advancements presented in this review aim to guide future research and development efforts, ultimately enhancing the effectiveness of ocular drug delivery and improving patient outcomes. Full article