Search Results (1,139)

Background: The UK has a high incidence of lameness in cattle, which is costly in terms of economics and welfare. Most causes of bovine lameness originate in the foot but there are several different conditions causing lameness. Quantifying the relative prevalence of different lameness causing lesions allows for the focus of preventative measures and research on the most common conditions. Methods: This study analysed trimming records from 23 professional foot trimmers working in the Southwest of England. A total of 97,944 recorded lesions over a 5-year period were analysed for lesion identity, lesion severity, repeat presentation, foot affected, claw affected and whether they were from dairy or beef cattle. Results: The most frequently recorded lesions were digital dermatitis (32%), white line disease (21%), sole ulcer (19%) and sole haemorrhage (13%). White line disease had the highest percentage of lesions requiring veterinary attention and most frequently re-presented. Most lesions were in hind feet and there was a small but significantly greater number recorded in right feet. Beef cattle had a higher percentage of digital dermatitis and lower percentage of sole ulcer compared with dairy cattle. Conclusions: Digital dermatitis was the most common foot lesion of all cattle types. Most feet with lesions only appeared in the data set once, suggesting broadly that foot trimming was largely effective at resolving new foot lesions. More white line lesions were re-presented, along with having more severe grades compared with other lesions. Therapeutic trimming of chronic lesions appeared to be less successful, with re-presentations, on average, every 93 days, compromising welfare for extended periods, and requiring consideration of different veterinary treatment options. Full article

Shaftless propulsion technology delivers high efficiency and low noise for subsea installations and marine vessels. To enhance thrust performance, the streamlined aft-body contour imposes stringent demands on geometric compatibility between the rim-driven thruster (RDT) motor and hull. This necessitates advanced electromagnetic characterization of conical motors. This paper proposes an equivalent magnetic circuit model (EMCM) that accounts for end effects and magnetic saturation in both the stator and rotor cores for the magnetic field analysis of conical permanent magnet synchronous motor (CPMSM). A 3D EMCM is developed by decomposing the air-gap flux into radial/axial/tangential components. End-field nonlinearities are addressed via lumped-parameter network modeling. Innovatively, a trapezoidal expanded magnet layout and magnet-pole-trimming technology are adopted to ensure sinusoidal flux distribution. Finally, a 10.5 kW prototype with a conical angle of 6.7 degrees is designed using the EMCM and verified through a finite-element analysis (FEA) and experiments. This research provides a theoretical framework for the rapid electromagnetic analysis of the CPMSM. Full article

(1) Background: Clear aligners are favored for their aesthetics in orthodontics, with newer 3D-printed technologies allowing the design of aligners with differential thicknesses and materials, offering advantages in terms of force distribution on the teeth, thereby optimizing treatment biomechanics. This study aimed to compare the initial and final forces of three types of 3D-printed aligners (with different thickness gradients and gingival margins) and traditional thermoformed aligners (with different gingival margins), evaluating stress relaxation and force consistency to determine which material and configuration may be optimal for better force distribution; (2) Methods: Twenty-seven 3D-printed aligners with three design variations and 18 thermoformed aligners were analyzed. Customized models were used to assess force at specific points on the upper incisor (1.1) and molar (2.6). A 3 h stress-relaxation test was conducted at 37 °C, and force data were recorded every second using a motorized compression stand. Statistical analysis was performed using ANOVA, post hoc tests, and Kruskal–Wallis tests for comparisons; (3) Results and Conclusions: Aligners with vertical and horizontal thickness gradients and a gingival margin trimmed 2 mm above the gingival contour exerted the highest forces, particularly at incisal/occlusal points. No significant differences in stress relaxation were observed. The force applied to the molars was consistently higher than the force applied to the incisors. These 3D-printed aligners with both horizontal and vertical gradients may offer a viable alternative to thermoformed aligners. Full article

The multivariate Vasicek model is commonly used to capture mean-reverting dynamics typical for short rates, asset price stochastic log-volatilities, etc. Reparametrizing the discretized problem as a VAR(1) model, the parameters are oftentimes estimated using the multivariate least squares (MLS) method, which can be susceptible to outliers. To account for potential model violations, a maximum trimmed likelihood estimation (MTLE) approach is utilized to derive a system of nonlinear estimating equations, and an iterative procedure is developed to solve the latter. In addition to robustness, our new technique allows for reliable recovery of the long-term mean, unlike existing methodologies. A set of simulation studies across multiple dimensions, sample sizes and robustness configurations are performed. MTLE outcomes are compared to those of multivariate least trimmed squares (MLTS), MLE and MLS. Empirical results suggest that MTLE not only maintains good relative efficiency for uncontaminated data but significantly improves overall estimation quality in the presence of data irregularities. Additionally, real data examples containing daily log-volatilities of six common assets (commodities and currencies) and US/Euro short rates are also analyzed. The results indicate that MTLE provides an attractive instrument for interest rate forecasting, stochastic volatility modeling, risk management and other applications requiring statistical robustness in complex economic and financial environments. Full article

Bore deterioration phenomena, such as surface ablation, wear, aluminum deposition, and structural bending, severely restrict the service life and performance of electromagnetic launchers. Efficient bore inspection is necessary to study the deterioration mechanism, guide design, and health management. In this paper, an inspection system for electromagnetic launchers is presented which utilizes structured light scanning, time-of-flight, and laser alignment methods to acquire bore laser point clouds, and ultimately extracts the surface deformation of rails and insulators, as well as the straightness of the bore, through the registration of point cloud data. First, the system composition and detection principles are introduced. Second, the impacts of the detection device’s attitude deflection are analyzed. Next, focusing on the key registration issue of laser point clouds, a coarse registration method is proposed which utilizes the arc features of the rail by combining circle and parabola equations, thereby maximizing registration efficiency. Finally, the trimmed iterative closest-point (TrICP) algorithm is employed for fine registration to handle non-axisymmetric bore deformations. The experimental results show that the proposed method can detect bore surface deformation and straightness efficiently and precisely. Full article

There has been considerable debate about whether contemporary Western societies are experiencing an increase in narcissistic tendencies, often referred to as a “narcissism epidemic”. This rise highlights the importance of understanding the origins of narcissism, particularly regarding its potential association with parenting styles. Such insights can inform treatment approaches and contribute to paradigm shifts in developmental psychology. This systematic review and meta-analysis examine how different parenting styles are associated with the development of narcissistic traits, using both partial and zero-order correlations as measures of effect. To ensure a consistent conceptualization of parenting styles, the results were evaluated using Baumrind’s parental styles typology. The review follows PRISMA guidelines and is registered in PROSPERO (CRD42024516395). Studies published in English or Portuguese since 2000 were sourced from PubMed (1039 articles) and Scopus (2120 articles), resulting in a final sample of 53 studies across 38 articles. Data synthesis included assessment of statistical heterogeneity (${\mathrm{I}}^2$ statistic), publication bias (funnel plots, Egger’s test, and the trim and fill method), and methodological quality (adapted Newcastle–Ottawa Scale, NOS). Additionally, sensitivity analyses were conducted to evaluate the effect of excluding studies scoring below eight on the NOS by comparing results from analyses with all studies versus high-quality studies only. Results indicate a significant, albeit weak, association between parenting styles and narcissistic traits, with notable variations between maternal and paternal influences. This analysis provides a comprehensive perspective on the interplay between parenting approaches and the emergence of narcissistic characteristics, underscoring the complexity of factors that contribute to narcissism in contemporary society. Full article

Coal mining machine positioning technology is the key to realizing unmanned and intelligent mining of the comprehensive mining zone. Based on the traditional Strapdown Inertial Navigation System combined with Kalman-filtering coal mining machine positioning technology, non-integrity constraints are introduced, and the error of the output of the above system is filtered by an optimized Kalman filtering method proposed in this paper: non-Gaussian summation and a parallel Kalman filter bank. This method decomposes the non-Gaussian system into a linear combination of multiple Gaussian systems through the parallel Kalman filter group, then fuses the states occupying different weight coefficients and designs a method of Gaussian-term number trimming to solve the problem of parameter explosion in the filtering process, and ultimately obtains the optimal estimation of the positioning information of the coal mining machine. Experiments show that, for the coal mining machine positioning issue in the complex noise interference environment of intelligent mines, the non-Gaussian summation and parallel Kalman filter group method in this paper, compared with the traditional particle filtering method, greatly reduces the three-dimensional attitude error, three-dimensional velocity error, three-dimensional position error in the nine dimensional parameters of the estimation error, and the average estimation error. The average estimation error is reduced by 49%, 52%, 50%, 53%, 51%, 48.8%, 50.1%, 54%, and 51.3%, respectively, which significantly improves the positioning accuracy of coal mining machines, and has stronger real-time performance, stability, and accuracy in the coal mining machine positioning system. Full article

Aiming at the path planning problem of an unmanned aerial vehicle (UAV) in a complex unknown environment, this paper proposes a cooperative path planning algorithm for multiple UAVs. Using the local environment information, several rolling path plannings are carried out by the Artificial Potential Field Bidirectional-Rapidly exploring Random Trees (APF B-RRT*) algorithm. The APF B-RRT* algorithm optimizes the search space by pre-sampling and adapts with an adaptive step while fusing with the APF algorithm for guiding sampling. Then, the generated path is trimmed and smoothed to obtain the optimized path. Then, through the sampling constraint, several paths can be planned at the same time, which are guaranteed not to collide. The model predictive control (MPC) is used to realize the cooperative control of the UAVs, that is, the UAVs reached the destination simultaneously along the planned path. This algorithm achieves some progress in solving the problems of slow convergence speed, an unstable result and an unsmooth path in UAV path planning. Simulation and comparison show that the APF B-RRT* algorithm has certain advantages in algorithm performance. Full article

Recent advancements in AI technologies have driven the extensive adoption of deep learning architectures for recognizing human behavioral patterns. However, the existing smoking behavior detection models based on object detection still have problems, including poor accuracy and insufficient real-time performance. Especially in complex environments, the existing models often struggle with erroneous detections and missed detections. In this paper, we introduce DAHD-YOLO, a model built upon the foundation of YOLOv8. We first designed the DBCA module to replace the bottleneck component in the backbone. The architecture integrates a diverse branch block and a contextual anchor mechanism, effectively improving the backbone network’s ability to extract features. Subsequently, at the end of the backbone, we introduce adaptive fine-grained channel attention (AFGCA) to effectively facilitate the fusion of both overarching patterns and localized details. We introduce the ECA-FPN, an improved version of the feature pyramid network, designed to refine the extraction of hierarchical information and enhance cross-scale feature interactions. The decoupled detection head is also updated via the reparameterization approach. The wise–powerful intersection over union (Wise-PIoU) is adopted as the new bounding box regression loss function, resulting in quicker convergence speed and improved detection outcomes. Our system achieves superior results compared to existing models using a self-constructed smoking detection dataset, reducing computational complexity by 23.20% while trimming the model parameters by 33.95%. Moreover, the mAP50 of our model has increased by 5.1% compared to the benchmark model, reaching 86.0%. Finally, we deploy the improved model on the RK3588. After optimizations such as quantization and multi-threading, the system achieves a detection rate of 50.2 fps, addressing practical application demands and facilitating the precise and instantaneous identification of smoking activities. Full article

Background: ‘Downstream’ adverse outcomes associated with transfusion-related immune modulation (TRIM) occur postoperatively. The potential associations between these outcomes (and costs) and perioperative transfusion are often not considered by clinicians and therefore underestimated. When considering TRIM, many advantages of intraoperative cell salvage (ICS) were previously confirmed. Methods: The main aim of this retrospective observational study was to evaluate the cost implications associated with perioperative adverse outcomes following allogeneic blood transfusion (ABT). Secondly, further analysis considered downstream costs following ICS. This manuscript does not aim to provide evidence of improved outcomes following ICS compared to ABT. These outcomes were previously demonstrated. Instead, it is important to consider downstream cost implications if patients receive ABT, despite previously proven benefits related to ICS. Surgical patients (n = 2129) receiving blood transfusion at the Royal Brisbane and Women’s Hospital (Queensland, Australia) (2016–2018) were included: receiving ICS only (n = 115), allogeneic red blood cells (RBCs) only (n = 1944), or RBCs and ICS (n = 70). Data retrieved from eight hospital databases were exported, and a novel Structured Query Language (SQL) database was developed to link data points. Adverse outcomes previously associated with TRIM were assessed using International Classification of Diseases-10 (ICD-10) coded data. Generalised linear models were used to model costs and adjust for confounding factors. Results: Most adverse outcomes (≥3) occurred following RBCs and ICS (37.1%), followed by RBCs (23.7%) and ICS (16.5%). As potentially important determinants of overall expenditure, the lowest marginal mean intensive care stay (days, cost) was after ICS (2.1 days, AUD 10,027), followed by RBCs and ICS (3.8 days, AUD 18,089), and then RBCs (5.5 days, AUD 26,071). When considering blood products (other than packed red blood cells), the average cost per patient was lowest for ICS (AUD 48), followed by RBCs (AUD 533) and RBCs and ICS (AUD 819). Conclusions: We confirmed that the cost associated with allogeneic blood transfusion was significant; patients receiving packed red blood cells (pRBCs) experienced more adverse outcomes and higher hospital costs than those receiving ICS. These results are limited to retrospective data and require further prospective validation. Full article

To reveal the scribing mechanism of ultra-thin glass, single-factor scribing tests were carried out. The effects of the scribing wheel angle θ, scribing force F, and scribing speed v on the lateral cracks width w, scribing depth d, median cracks size l, and cross-section deflection angle α were analyzed to present the scribing quality. The results show that w increases with an increase in θ and F. Further, l and d increase with an increase in F. However, d shows an increasing trend with the increase in θ, and l shows a decreasing trend. In the range of 120–140°, α shows a trend of increasing first and then decreasing with an increase in F. The 120° scribing wheel angle, 20 N scribing force, and 100–400 mm/s scribing speed show the best scribing quality, which limits micro-cracks at the initiation stage without any damage or chipping. Under this condition, the breaking surface edges were free of debris and cracks. A smooth and trim Wallner ripple was obtained from the median cracks with a minimum deflection angle. Full article

Infection with the turkey hemorrhagic enteritis virus (THEV) can cause hemorrhagic enteritis, which affects young turkeys. This disease is characterized by bloody diarrhea and immunosuppression (IMS), which is attributed to apoptosis of infected B cells. Secondary infections due to IMS exacerbate economic losses. We performed the first transcriptomic analysis of a THEV infection to elucidate the mechanisms mediating THEV-induced IMS. After infecting and sequencing mRNAs of a turkey B-cell line, trimmed reads were mapped to the host turkey genome, and gene expression was quantified with StringTie. Differential gene expression analysis was followed by functional enrichment analyses using gprofiler2 and DAVID from NCBI. RT-qPCR of select genes was performed to validate the RNA-seq data. A total of 2343 and 3295 differentially expressed genes (DEGs) were identified at 12 hpi and 24 hpi, respectively. The DEGs correlated with multiple biological processes including apoptosis, ER unfolded protein response, and cell maintenance. Multiple pro-apoptotic genes, including APAF1, BMF, BAK1, and FAS were upregulated. Genes that play a role in ER stress-induced unfolded protein response including VCP, UFD1, EDEM1, and ATF4 were also upregulated and may contribute to apoptosis. Our data suggest that several biological processes and pathways including apoptosis and ER response to stress are important aspects of the host cell response to THEV infection. It is possible that interplay between multiple processes may mediate apoptosis of infected B-cells, leading to IMS. Full article

A study on aerodynamic design studies of a blended wing–body (BWB) unmanned aerial vehicle (UAV) operating at low Mach numbers is presented. First, a parametric investigation based on analytical equations is carried out to identify the range of the necessary wetted area for the UAV to maximize endurance at a Mach number close to 0.1. A base-of-reference configuration is designed, and its aerodynamic performance is evaluated by utilizing a panel method in Xflr5. An optimization algorithm is then incorporated to trim the UAV and produce the ‘clean’ configuration. Computational fluid dynamics (CFD) simulations are performed within the OpenFoam environment to produce first the updated drag polars, and then, to analyze the integration of the nacelle and the pair of electric ducted fans (EDFs) used for the propulsion system. In particular, when examining the integration of the nacelle with a spinning electric ducted fan (EDF) standing as the propulsion system of the vehicle, a rotating, sliding mesh computational approach is adopted. Results indicate that the clean configuration is characterized by strong longitudinal stability so that the UAV has the potential to fly trimmed at very low speeds. Mounting EDFs on the back of the fuselage is conducive to higher loading with minimal drag penalty. An increased lift-to-drag ratio is achieved. Reduced wake mixing due to the EDF’s jet flow is observed. The spanwise flow that is conducive to pitch brake and loss of stability is also weak, as the suction produced by the EDF diverts the flow inboard. Full article

Background: Tumor metastasis and poor drug efficacy are two of the most common causes of therapeutic failure in cancer patients. The underlying molecular mechanism requires further exploration, and novel effective curative strategies are urgently needed. Nature is a rich source of novel drugs, and Lycorine hydrochloride (Lyc.HCL) is a natural alkaloid with tremendous therapeutic potential. However, the molecular mechanisms of its antitumor activity are still unknown. In the current study, we investigated the effects and mechanisms of Lyc.HCL against esophageal squamous cell carcinomas (ESCCs), which pose serious threats to human life. Methods: An MTS assay and a clone formation assay were used to assess the viability of ESCC cell lines after Lyc.HCL treatment in vitro. Apoptosis and cell cycle regulation were analyzed using flow cytometry. Wound healing and Transwell assays were used to analyze cell migration, while invasion was analyzed using the Matrigel Transwell assay. We detected the expression of tripartite motif-containing 22 (TRIM22) through immunohistochemistry and Western blotting. A docking experiment was performed to explore the targets of Lyc.HCL. The expression levels of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/extracellular signal-regulated kinase (Erk) pathway components were detected through Western blotting. A rescue experiment was performed to determine the potential role of TRIM22. In addition, we explored the in vivo anti-ESCC effects and mechanism of Lyc.HCL by using it to treat tumor-bearing mice. Results: The Lyc.HCL treatment was found to inhibit esophageal squamous cell carcinoma cell proliferation both in vitro and in vivo by blocking the cell cycle at the G2 phase, inhibiting cell migration and invasion. We found that the TRIM22 protein was highly expressed in ESCCs but not in normal esophageal tissue. Lyc.HCL directly targeted TRIM22, decreasing the expression of TRIM22 and the JAK2/STAT3 and Erk signaling pathways, both in vitro and in vivo. Using animal experiments, we observed that the depletion of TRIM22 delayed tumor growth, but this effect was significantly reversed upon TRIM22 overexpression. Conclusions: Taken together, these findings demonstrate that Lyc.HCL can effectively suppress ESCC both in vitro and in vivo by targeting TRIM22 and regulating the JAK2/STAT3 and Erk pathways. These results suggest that Lyc.HCL may serve as a potential novel therapeutic for ESCC, with TRIM22 emerging as a promising target for treatment. Full article

The late spring cold spell severely affects the growth of litchi flower buds. Melatonin, as a signaling molecule, can enhance the plant’s ability to resist abiotic stress by regulating multiple physiological processes. However, there are few studies on the function of melatonin in litchi under cold stress. In the present study, 100 μM of melatonin was selected based on the ABA content in litchi seedlings. To identify genes potentially involved in melatonin and cold stress conditions in litchi, four RNA-seq libraries of litchi leaves under melatonin and cold conditions were constructed. In total, 6.4–8.5 Gb of trimmed bases were generated in each library. Thirty-five genes were randomly selected for qRT-PCR analysis. The results showed a strong positive correlation between the data from qRT-PCR and RNA-seq. A total of 4590 differentially expressed genes (DEGs) were identified in the treatment of melatonin (1845) and melatonin in cold condition (2745). The expression of several genes belonging to starch and sucrose metabolism, plant hormones (auxin, ABA), MAPK, and alpha-linolenic acid metabolism pathways were differentially expressed. The enhanced carbohydrate metabolism might lead to litchi seedlings treated with melatonin to produce more metabolic energy. Abscisic acid can improve cold tolerance. Collectively, our results reveal that pretreatment with melatonin (100 μM) protects litchi seedlings from cold stress through plant hormones and carbohydrate metabolism and provides potential genes for future research. Full article