A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67
<p>Sectional surface of the uterus with an endometrial polyp from the fundus of the uterus; histological result: malignant endometrial polyp.</p> "> Figure 2
<p>(<b>a</b>) Foci of endometrial atypical hyperplasia showing architectural features on low magnification: crowded aggregates with altered and branching glands. In these areas of AEH, the glands exceeded the stroma, haematoxylin–eosin, ×50. (<b>b</b>) Fragment of the endometrial polyp characterised by the presence of atypical hyperplastic features confined to the polyp, haematoxylin–eosin, ×50. (<b>c</b>) The tumour cells are arranged predominantly in a micropapillary pattern in which they surround small spaces containing eosinophilic material (Call–Exner bodies), haematoxylin–eosin, ×50. (<b>d</b>) The tumour cells have uniform pale round nuclei with nuclear grooves (coffee beans) and scant cytoplasm, haematoxylin–eosin, ×400.</p> "> Figure 3
<p>An additional immunohistochemical examination showed that the atypical hyperplastic glands confined to the polyp showed a strong expression for (<b>a</b>) ER, anti-ER ×100; (<b>b</b>) PR, anti-PR ×100; (<b>c</b>) the immunohistochemical examination presented a lack of expression of Ki-67, anti Ki-67 ×100; (<b>d</b>) the immunohistochemical examination presented a lack of expression of p-53, anti-p53 ×100.</p> "> Figure 3 Cont.
<p>An additional immunohistochemical examination showed that the atypical hyperplastic glands confined to the polyp showed a strong expression for (<b>a</b>) ER, anti-ER ×100; (<b>b</b>) PR, anti-PR ×100; (<b>c</b>) the immunohistochemical examination presented a lack of expression of Ki-67, anti Ki-67 ×100; (<b>d</b>) the immunohistochemical examination presented a lack of expression of p-53, anti-p53 ×100.</p> ">
Abstract
:1. Introduction
2. Case Presentation
2.1. Patient Information
2.2. Clinical Examination and Diagnostic Assessment
2.3. Management
2.4. Histopathological Examination and Immunohistochemical Analysis of Malignant Endometrial Polyp
3. Discussion
Limitations
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Vladov, K.; Uchikova, E.; Koleva-Ivanova, M.; Yamakov, K.; Belovezhdov, V.; Yamakova-Vladova, G.; Hristova-Atanasova, E. A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67. Reports 2024, 7, 103. https://doi.org/10.3390/reports7040103
Vladov K, Uchikova E, Koleva-Ivanova M, Yamakov K, Belovezhdov V, Yamakova-Vladova G, Hristova-Atanasova E. A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67. Reports. 2024; 7(4):103. https://doi.org/10.3390/reports7040103
Chicago/Turabian StyleVladov, Krum, Ekaterina Uchikova, Maria Koleva-Ivanova, Kamen Yamakov, Veselin Belovezhdov, Gita Yamakova-Vladova, and Eleonora Hristova-Atanasova. 2024. "A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67" Reports 7, no. 4: 103. https://doi.org/10.3390/reports7040103
APA StyleVladov, K., Uchikova, E., Koleva-Ivanova, M., Yamakov, K., Belovezhdov, V., Yamakova-Vladova, G., & Hristova-Atanasova, E. (2024). A Case Report of the Synchronous Occurrence of Ovarian Granulosa Cell Tumour and Malignant Endometrial Polyp with Immunohistochemical Expression of Hormone Receptors and Biomarkers p-53 and Ki-67. Reports, 7(4), 103. https://doi.org/10.3390/reports7040103