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Volume 84
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10.5603/PiAP.a2015.0081
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

Abnormalities in Lung Volumes and Airflow in Children with Newly Diagnosed Connective Tissue Disease

by
Joanna Peradzyńska
1,
Katarzyna Krenke
2,*,
Anna Szylling
2,
Beata Kołodziejczyk
3,
Agnieszka Gazda
3,
Lidia Rutkowska-Sak
3 and
Marek Kulus
2
1
Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland
2
Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw, Żwirki i Wigury 63A, 02-091 Warsaw, Poland
3
Department of Pediatric Rheumatology, Institute of Rheumatology, Warsaw, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2016, 84(1), 22-28; https://doi.org/10.5603/PiAP.a2015.0081
Submission received: 27 August 2015 / Revised: 24 November 2015 / Accepted: 17 December 2015 / Published: 17 December 2015

Abstract

Introduction: Connective tissue diseases (CTDs) of childhood are rare inflammatory disorders, involving various organs and tissues including respiratory system. Pulmonary involvement in patients with CTDs is uncommon but may cause functional impairment. Data on prevalence and type of lung function abnormalities in children with CTDs are scarce. Thus, the aim of this study was to asses pulmonary functional status in children with newly diagnosed CTD and follow the results after two years of the disease course. Material and methods: There were 98 children (mean age: 13 ± 3; 76 girls), treated in Department of Pediatric Rheumatology, Institute of Rheumatology, Warsaw and 80 aged-matched, healthy controls (mean age 12.7 ± 2.4; 50 girls) included into the study. Study procedures included medical history, physical examination, chest radiograph and PFT (spirometry and whole body-plethysmography). Then, the assessment of PFT was performed after 24 months. Results: FEV1, FEV1/FVC and MEF50 were significantly lower in CTD as compared to control group, there was no difference in FVC and TLC. The proportion of patients with abnormal lung function was significantly higher in the study group, 41 (42%) vs. 9 (11%). 24-months observation didn’t reveal progression in lung function impairment. Conclusions: Lung function impairment is relatively common in children with CTDs. Although restrictive ventilatory pattern is considered typical feature of lung involvement in CTDs, airflow limitation could also be an initial abnormality.
Keywords: lung function tests; rheumatic diseases of childhood; pulmonary involvement lung function tests; rheumatic diseases of childhood; pulmonary involvement

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MDPI and ACS Style

Peradzyńska, J.; Krenke, K.; Szylling, A.; Kołodziejczyk, B.; Gazda, A.; Rutkowska-Sak, L.; Kulus, M. Abnormalities in Lung Volumes and Airflow in Children with Newly Diagnosed Connective Tissue Disease. Adv. Respir. Med. 2016, 84, 22-28. https://doi.org/10.5603/PiAP.a2015.0081

AMA Style

Peradzyńska J, Krenke K, Szylling A, Kołodziejczyk B, Gazda A, Rutkowska-Sak L, Kulus M. Abnormalities in Lung Volumes and Airflow in Children with Newly Diagnosed Connective Tissue Disease. Advances in Respiratory Medicine. 2016; 84(1):22-28. https://doi.org/10.5603/PiAP.a2015.0081

Chicago/Turabian Style

Peradzyńska, Joanna, Katarzyna Krenke, Anna Szylling, Beata Kołodziejczyk, Agnieszka Gazda, Lidia Rutkowska-Sak, and Marek Kulus. 2016. "Abnormalities in Lung Volumes and Airflow in Children with Newly Diagnosed Connective Tissue Disease" Advances in Respiratory Medicine 84, no. 1: 22-28. https://doi.org/10.5603/PiAP.a2015.0081

APA Style

Peradzyńska, J., Krenke, K., Szylling, A., Kołodziejczyk, B., Gazda, A., Rutkowska-Sak, L., & Kulus, M. (2016). Abnormalities in Lung Volumes and Airflow in Children with Newly Diagnosed Connective Tissue Disease. Advances in Respiratory Medicine, 84(1), 22-28. https://doi.org/10.5603/PiAP.a2015.0081

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