Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: a new mode of regulation of the MAP kinase cascade
H Matsuura, H Nishitoh, K Takeda, A Matsuzawa… - Journal of Biological …, 2002 - ASBMB
JSAP1 (also termed JIP3) is a scaffold protein that interacts with specific components of the
JNK signaling pathway. Apoptosis signal-regulating kinase (ASK) 1 is a MAP kinase kinase
kinase that activates the JNK and p38 mitogen-activated protein (MAP) kinase cascades in
response to environmental stresses such as reactive oxygen species. Here we show that
JSAP1 bound ASK1 and enhanced ASK1-and H 2 O 2-induced JNK activity. ASK1
phosphorylated JSAP1 in vitro and in vivo, and the phosphorylation facilitated interactions of …
JNK signaling pathway. Apoptosis signal-regulating kinase (ASK) 1 is a MAP kinase kinase
kinase that activates the JNK and p38 mitogen-activated protein (MAP) kinase cascades in
response to environmental stresses such as reactive oxygen species. Here we show that
JSAP1 bound ASK1 and enhanced ASK1-and H 2 O 2-induced JNK activity. ASK1
phosphorylated JSAP1 in vitro and in vivo, and the phosphorylation facilitated interactions of …