Cerebral pericytes—a second line of defense in controlling blood-brain barrier peptide metabolism
D Krause, J Kunz, R Dermietzel - Frontiers in cerebral vascular biology …, 1993 - Springer
D Krause, J Kunz, R Dermietzel
Frontiers in cerebral vascular biology: transport and its regulation, 1993•SpringerThe production and use of antibodies specific for brain blood vessels represents a powerful
approach for the evaluation of the molecular and functional properties of the blood-brain
barrier (BBB). Such antibodies can be used as immunocytochemical probes to detect
antigenic determinants of the cerebral blood vessels and to define the biochemical nature of
these antigens. We therefore produced blood-brain barrier specific monoclonal antibodies
by using isolated brain microvessels as a collective immunogen.
approach for the evaluation of the molecular and functional properties of the blood-brain
barrier (BBB). Such antibodies can be used as immunocytochemical probes to detect
antigenic determinants of the cerebral blood vessels and to define the biochemical nature of
these antigens. We therefore produced blood-brain barrier specific monoclonal antibodies
by using isolated brain microvessels as a collective immunogen.
Abstract
The production and use of antibodies specific for brain blood vessels represents a powerful approach for the evaluation of the molecular and functional properties of the blood-brain barrier (BBB). Such antibodies can be used as immunocytochemical probes to detect antigenic determinants of the cerebral blood vessels and to define the biochemical nature of these antigens. We therefore produced blood-brain barrier specific monoclonal antibodies by using isolated brain microvessels as a collective immunogen.
Springer