Robin Williams' final on-screen film appearance. His final film, Absolutely Anything (2015), would only feature his voice.
This movie is dedicated to the memories of Mickey Rooney and Robin Williams. Both appeared in the movie, but died before its release.
In Night at the Museum (2006), Teddy says the exhibits have been coming to life since the tablet of Ahkmenrah arrived in 1952. In this movie, Cecil says the tablet arrived in New York City following the expedition to Egypt in 1938. In the first movie, Ahkmenrah says he spent some years in England at one of the universities, suggesting he was sent to England for many years before he arrived in New York City.
Teddy is shown quoting fellow U.S. Presidents John F. Kennedy, George W. Bush, and Franklin D. Roosevelt. He also quotes William Shakespeare's Henry V.
Ella Stiller, Quinn Dempsey Stiller: (at around 1h 11 mins) Ben Stiller's children made cameo appearances in the film, as the children staring at Larry and the gang, when they were sitting on the bus.
Sophie Levy: (at around 16 mins) The girl named Sophie that Larry addresses in his apartment is Director Shawn Levy's daughter.