- Frederico Auditore: It is a good life we lead, brother.
- Ezio Auditore da Firenze: The best. May it never change.
- Frederico Auditore: And may it never change us.
- Maria de' Mozzi: You should find an outlet.
- Ezio Auditore da Firenze: I have plenty of outlets!
- Maria de' Mozzi: [seriously] I meant besides vaginas.
- Ezio Auditore da Firenze: [irritatingly] Mother!
- Ezio Auditore da Firenze: I thought... I thought I was beyond this. But I'm not. I've waited too long, lost too much. Requiescat in Pace, you bastard!
- Rodrigo Borgia: You can't. You can't! This is my destiny. MINE! I am the prophet!
- Ezio Auditore da Firenze: You never were.
- Rodrigo Borgia: Get it over with then.
- Ezio Auditore da Firenze: No. Killing you won't bring my family back. I'm done. Nulla è reale, tutto è lecito. Requiescat in pace.
- [Nothing is true, everything is permitted. Rest in peace]
- Ezio Auditore da Firenze: Buona sera, Vieri! We were just talking about you. I'm surprised to see you here. I thought the Pazzi hired others to do their dirty work.
- Vieri de' Pazzi: It's your family that cries for guards when there's trouble, codardo
- [Italian word for 'coward']
- Vieri de' Pazzi: ! Afraid to handle things your self?
- Ezio Auditore da Firenze: Your sister seemed quite satisfied with the 'handling' I gave her earlier.
- Ezio Auditore da Firenze: What do you even want with the Vault, Rodrigo?
- Rodrigo Borgia: Don't you know what lies within? Or do you mean to tell me the great and powerful Assassins didn't figure it out?
- Ezio Auditore da Firenze: Figure out what?
- Rodrigo Borgia: God! It's God that dwells within.
- Ezio Auditore da Firenze: You expect me to believe that God lives beneath il Vaticano?
- Rodrigo Borgia: A more logical location than a kingdom on a cloud, don't you think? Surrounded by singing angels and cherubim. Makes for a lovely image, but the truth is far more interesting.
- Ezio Auditore da Firenze: Let's say I was to believe you - what do you think He'll do when you open that door?
- Rodrigo Borgia: I don't care. It's not approval I'm after, just power.
- Ezio Auditore da Firenze: And you think He'll give it up?
- Rodrigo Borgia: Whatever lies beyond that wall won't be able to resist the Staff and Apple. They were MADE for felling Gods.
- Ezio Auditore da Firenze: God is meant to be all knowing. All powerful. You think a couple of ancient relics can harm Him.
- Rodrigo Borgia: You know nothing, boy. You take your image of the creators from an ancient book - a book, mind you, written by men.
- Ezio Auditore da Firenze: You are the Pope! And yet you dismiss the central text of your Faith?
- Rodrigo Borgia: Are you so naïve? I became Pope because it gave me access. It gave me power! Do you think I believe a single god-damned word of that ridiculous book? It's all lies and superstition. Just like every other religious tract written over the past ten thousand years.
- Ezio Auditore da Firenze: [about to fight Rodrigo Borgia, hand-to-hand style] It's over Rodrigo. No more tricks, no more ancient artifacts, no more weapons. Let's see what you are made of, old man!
- Vieri de' Pazzi: I'm sorry, were you hoping for a confession?
- [Vierri dies]
- Ezio Auditore da Firenze: [yelling in Italian] Piece of shit! I only wish you'd suffered more! You met the fate you deserved! I hope you...
- Mario Auditore: [approaching] Enough, Ezio! Show some respect!
- Ezio Auditore da Firenze: [throwing down Vierri's corpse] Respect? After all that's happened? Do you think he would have shown either of us such kindness?
- Mario Auditore: You have *killed* Vieri; do *not* become him.
- [Mario kneels down to close Vierri's eyes]
- Mario Auditore: Requiescat in pace.
- [after being locked in the trunk of a car]
- Desmond Miles: Thanks for that. It was great, being shoved in the trunk, bouncin' around. Loved it...
- Lucy Stillman: [cutting him off] Let's go.
- Rodrigo Borgia: So sorry to have claimed your prize, Assassin. Did you honestly think I wouldn't expect you to follow? That I didn't plan for it? We've been at this a lot longer than you.
- Ezio Auditore da Firenze: Doesn't seem like anybody showed up, Rodrigo! How many people have died for this? For what's in this box? And look- There's nobody here!
- Rodrigo Borgia: You claim not to be a believer. And yet, here you are... Don't you see him? The Prophet is already here... I am the Prophet. Now give me the Apple.
- Ezio Auditore da Firenze: Come and take it from me.
- Mario Auditore: Laa shay'a waqi'un moutlaq bale kouloun moumkine. These are the words spoken by our ancestors that lay at the heart of our creed.
- Niccolò Machiavelli: Where other men blindly follow the truth, remember...
- Ezio Auditore da Firenze: Nothing is true.
- Niccolò Machiavelli: Where other men are limited, by morality or law, remember...
- Ezio Auditore da Firenze: Everything is permitted.
- Niccolò Machiavelli: We work in the dark, to serve the light. We are assassins.
- [Everyone collectively]
- Niccolò Machiavelli: Nothing is true, everything is permitted.
- Rodrigo Borgia: This is a losing battle for you, hombrecito. You will die by my hand, just like your father. This war has been going on far longer than either of us have played a role.
- Uberto: You would have done the same, to save the ones you loved...
- Ezio Auditore da Firenze: Yes, I would, and I have.
- Rodrigo Borgia: We put our faith in your family and you repay us with inaction and incompetence? Then when asked to account for your failures, you make excuses and insult us? How do you expect me to respond?
- Jacopo de' Pazzi: I... don't know...
- Rodrigo Borgia: It's alright, I do.
- [stabs Jacopo]