Grey's Anatomy is a surprisingly addictive show. The plot lines are an interesting blend of soap opera, drama, and comedy--it's not really like anything else, but at the same time, it occasionally feels pedestrian. However, it's very well done--good writing, great acting, and well directed.
Sandra Oh stands out for her comic timing, but the entire cast is superb. It's not as grave as ER, but is just as compelling. Also, it's a little more accessible than ER and some of the more serious medical dramas. The show is definitely worth catching--if you can't watch it when it airs, TiVo it or rent the first season DVD. It's well worth the time spent! It's great for marathon viewings!
