When burning book gets out of control, a flaming bit of paper wafts up to the curtains and starts burning them, yet Annie never notices or puts it out. Later the curtains are just fine.
Near the end, Paul pokes Annie in the eyes and makes her bleed, but in the next shot when she's on the floor, there is no blood under her eyes.
When Buster reads one of the "Dragon Lady" articles in the library, under the picture it says, "...There is a higher justice than that of man, I will be judged by Him." In the close-up shot, the mistake is corrected and now says, "...There is a justice higher than that of man, I will be judged by Him."
In the scene where Paul gets the knife, an exterior shot of Annie's house is shown and her Jeep is already parked next to the house, even though in a later shot her headlights flash through Paul's window as Annie pulls up to her house.
The typewriter lands upside down after Paul hits Annie with it, yet appears in the next shot right side up.
During the dinner scene, the penguin figurine that Paul replace facing the wrong direction can be seen facing the right way, even though this is before Annie confronts him about it. However, Annie discovered the misplaced figurine long before this, probably the day it happened. During the hobbling scene, she tells Paul that she knows he's been out of his room twice. It's never explicitly said how she knows about the second time, but likely she discovered that the knife was missing.
Although Buster's wife would have missed him after he didn't come back from Annie's house, he never told her where he was going, so it's not unreasonable that for one night, no one went there to look for him.
When Annie flicks through Paul's untitled manuscript when it is on the grill, it is revealed that a page of text is actually about Cameron Crowe's Say Anything... (1989), which was released as "Misery" was filming. The text is excerpted from a 1989 Movieline magazine article about Say Anything... (1989)'s box office performance.
There is an obvious "dummy" in Annie's place in the climactic fight scene with the typewriter.
In exterior shots of the house, the amount of snow on top of the house never changes, despite several scenes in which it is drenched in rain.
When Paul Sheldon is going through the "Memory Lane" scrapbook of Anne Wilkes, there is a news story from December 7, 1984 with the headline "Infant Deaths Return To Hospital Nursery Ward." The article's text is repeated twice after the first 3 paragraphs to fill in the newspaper space.
Deep footprints are clearly visible as the sheriff starts to climb down the snowy hillside to look for Paul's car; he even steps into at least one of them. Obviously previously-formed footprints from prior camera-takes of this scene.
When Paul tests the powder from the capsule before stashing it in the paper holder, he then pours the powder from each half of the capsule. In reality (and in fact in the shot where he opens the capsule) the powder would only be in one half.
When Paul Sheldon is paging through the memory book he comes across a clipping of Annie's nursing school graduation where the article says she has accepted a job in the "ederly care unit" instead of the "elderly care unit"
The Royal manual typewriter that Paul uses to write the new Misery novel weighed close to 50 pounds. With Paul bashing Annie over the head with it, she should have suffered a skull fracture and even been killed instantly. Yet she has the energy to get back up and fight Paul.
When Paul takes the knife out of his arm sling there is the sound of the knife brushing against metal.
Near the end, when Paul crawls through the doorway over the broken champagne glass, there is no sound of the broken glass dragging across the floor.
In the opening scene when Paul drinks champagne and lights a cigarette, you can see a patch of matchbox material glued to his thumb when he lights a match with his finger.
When Paul is in the kitchen for the first time, a crewmember is reflected in the corner of the stove, during the close-up of the knives.
In the overhead shot of Paul's room, while Paul is crawling towards the doorway after the fight, two shadows, each moving at different times, can be seen in the left side of the hallway.
When Marcia Sindell calls Buster up and asks if he has seen or heard anything about Paul Sheldon, he tells her that if he finds anything he will call her right back. Buster wouldn't be able to call her back because she did not give him her phone number, the firm she works for or where she is calling from.
When Annie shows the sheriff the guest room in which she pretends to write a novel, there should be a chair for her to sit on. But there's no chair to be seen anywhere near the table.
When Paul is looking at Annie's scrapbook, her name in one of the news headlines and the body of the article reads "Anne M. Wilkes," but the accompanying photo gives her name as "Annie C. Wilkes."
In the montage of shots indicating Paul's vast progress in the novel, we see a few shots of him writing the same paragraph over and over again, which begins, "for three days and three nights, Misery..." The same line appears again when Paul is typing the final chapter near the end.
Sheriff McCain speaks of a "dead branch" as a possible cause of the tree's being broken, but the entire tree is clearly snapped off halfway up the trunk; there is not merely a broken branch.
When Buster yells at his wife/deputy to stop, she slams on the brakes, even though they're on a snow-covered mountain road where another car presumably had an accident under similar conditions. A sheriff and his deputy should know how to drive in such conditions, which would not include sudden, sharp braking.