Steve is framed for charges of treason by Nazi spies and Wonder Woman finds herself in trouble when she loses her magic lasso while trying to rescue him.
Wonder Woman's sister Drusilla is sent from Paradise Island to Washington to tell Diana to come home. Drusilla discovers her own alter ego, Wonder Girl, and is kidnapped by the Nazis.
Drusilla accidentally reveals the location of Paradise Island to the Nazis who want to go there to harvest Feminum. Wonder Woman must return home to protect her people.
A scientist develops a method of making earthquakes. Later a German spy steals his work. Steve tries to find out what he is going to do with it. But they also find out he's infected with bubonic plague.
Top Nazi agent Wotan has two surgically altered doubles replace the man in charge of the Bureau of Printing and Engraving and his girlfriend, a waitress. The plan is to steal the $2 engraving plates and use them to collapse the American economy.
Andros has been kidnapped and taken to Germany. When Wonder Woman attempts to rescue him, Andros tells her he sees little difference between the way the Nazis and the Allied Forces wage war. Maj. Steve Trevor mounts a rescue mission of his own together with British agent Mallory.
When a rancher is dealing with rustlers, he calls his friend General Blankenship for help. So he sends Steve and Diana follows him. They try to find the rustlers and someone close to the rancher is helping them.