- Son of actor Brendan Gleeson and Mary (Weldon) Gleeson.
- His first name is pronounced "doh-nall" with the "m" being silent.
- Appeared in four films in 2015 and all four titles received nominations at the 88th Academy Awards. The films were: The Revenant (2015), Ex Machina (2014), Star Wars: Episode VII - The Force Awakens (2015) and Brooklyn (2015). The only other actor to achieve a similar record was Benedict Cumberbatch, who also appeared in four films that were Oscar nominated in 2013 - though he made a fifth movie that wasn't nominated.
- Competed with his father for Best Supporting Actor at the British Independent Film Awards in 2015. Brendan Gleeson won the category.
- Has a degree in media arts from the Dublin Institute of Technology.
- Was nominated for a Tony award for Best featured actor in a play for the role of Davey in Martin McDonagh's "The Lieutenant of Inishmore" on Broadway.
- Every film Domnhall appeared in in 2015 subsequently received multiple Academy Award nominations - Brooklyn, Ex Machina, Star Wars: The Force Awakens, and The Revenant.
- He was nominated for Best Supporting Actor at the 2015 British Independent Film Awards for his performance as Jim Farrell in Brooklyn (2015) but lost to his father Brendan Gleeson, who was nominated for his performance as Inspector Arthur Steed in Suffragette (2015). The younger Gleeson accepted the award for his father.
- As of 2016, has appeared in three films that were nominated for the Best Picture Oscar: True Grit (2010), The Revenant (2015) and Brooklyn (2015).
- 2011: Named as one of European films' Shooting Stars by European Film Promotion.
- Competed with his father for Best Lead Actor - Film at the Irish Film and Television Awards in 2014. Brendan Gleeson won the award.
- He and his father Brendan Gleeson have both starred in films with Tom Cruise that were directed by Doug Liman: Brendan in Edge of Tomorrow (2014) and Domhnall in American Made (2017).
- In the episode Be Right Back (2013) he interpreted a synthetic that falls in love with a human; In the movie Ex Machina (2014) he is a human who falls in love with a synthetic.
- Has appeared in seven films with his father Brendan Gleeson and these include Six Shooter (2004), Studs (2006), Perrier's Bounty (2009), Harry Potter and the Deathly Hallows: Part 1 (2010), Noreen (2010), Calvary (2014) and Psychic (2018).
- Has worked with his brother Brian Gleeson in What Will Survive of Us (2009), Noreen (2010), Mother! (2017) and Psychic (2018).
- Born two weeks before the release of Star Wars: Episode VI - Return of the Jedi (1983).
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