- Houde received this review for his portrayal as Joseph Gordon-Levitt's Alzheimer suffering father in Jonathan Levine's feature 50/50 (2011): Serge Houde's performance is one of the few horribly believable portrayals of Alzheimer's I've seen lately. The look of spaced-out absence and perennial curiosity he knows not to try to satiate because he'll just forget it is all too real for me and my experiences with my grandfather. When Adam tells his father he loves him late in the film, Houde's uncomprehending face and gentle but neutral one-word response was so familiar I burst into tears.
- Received this review from GQ Magazine's Tom Carson for his work in The Kennedys (2011): "...a terrific Sam Giancana (Serge Houde, and where has this formidable actor been all of Martin Scorsese's life?).".
- Director Jon Cassar had this to say about Houde's portrayal of Sam Giancana in The Kennedys (2011): "He has that steely stare that all those mafia bosses seem to have. He could scare you without a gun. He was wonderful. He is in pivotal scenes that tell the story of the Mafia connection to the White House. And Serge was wonderful in portraying that scary persona. Of course, in real life he's an absolute sweetheart, but I find that's often the case. Usually the worst, meanest guys on film are the nicest on the set." Jon Cassar interviewed by Gayle Macdonald for The Globe and Mail.
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