- Bill often had panic attacks before the live performance of a Saturday Night Live (1975) episode. To help him to relax, his wife came to the SNL studio to do Lamaze breathing exercises with him.
- He originally moved to Los Angeles, California with plans of becoming a director. At that time, before he became a regular cast member of Saturday Night Live (1975), being a comedian or actor was never something he thought of doing.
- In an interview with Conan O'Brien, Star Wars: Episode IV - A New Hope (1977)-fan Bill stated that he knew the first time he saw his then-girlfriend's apartment, she would be his wife: she had "Star Wars" curtains in her living room.
- During his audition for Saturday Night Live (1975), he was very nervous. Then while improvising his "Vinny Vedecci" character, Tina Fey laughed. Bill said Tina's laughter made him relax and helped him get through the audition and have fun.
- His Saturday Night Live (1975) audition was him performing impressions of Al Pacino, James Mason, Tony Blair, and Peter Falk as Vinnie Vedecci, his Italian talk-show host character.
- Is a producer on the 13th season of South Park (1997).
- Even though he is severely allergic to peanuts, in 2013 he was chosen to replace Robert Downey Jr. as the commercial voice of Planter's Nuts commercial mascot "Mr. Peanut".
- In the feature film, Hot Rod (2007), Bill portrays a character named Dave, who tells a story about tripping on acid (also known as LSD). In the acid trip story, Dave gets a piece of metal stuck in his eye. This acid trip and eye injury story actually happened to one of Bill's friends, who Bill subsequently took to watch the film.
- Part of Judd Apatow's stock company of actors. He has appeared in five of his films.
- Confessed to Ellen DeGeneres that one of his guilty pleasure TV shows is Snapped: Killer Couples (2013). He's also a huge fan of the true crime series Forensic Files (1996).
- Met his ex-wife Maggie Carey, while performing as a member of a comedy troupe in a backyard in Van Nuys, California (a suburb of Los Angeles, California). She was sitting in the front row, and afterwards they were introduced by a mutual friend.
- Monty Python, This Is Spinal Tap (1984), and early Woody Allen and Mel Brooks movies are his biggest comedic influences [Empire Online April 2008].
- Has been in six films that have grossed over 100 million dollars (Knocked Up (2007), Superbad (2007), Tropic Thunder (2008), Night at the Museum 2 (2009), Ice Age: Dawn of the Dinosaurs (2009) and Cloudy with a Chance of Meatballs (2009).
- While a guest on the PBS genealogy show Finding Your Roots with Henry Louis Gates, Jr. (2012), Hader discovered that he is directly descended from both King Edward I of England and Charlemagne, King of the Franks and first Holy Roman Emperor, who united most of Western Europe during the early Middle Ages.
- In May 2013, he announced he would leave Saturday Night Live (1975) on May 18, 2013, at the end of the 2013 season. He further announced his plans to move to Los Angeles, so both he and his filmmaker wife (Maggie Carey, now ex-wife, as of 2018) could pursue more opportunities there.
- Hader and his ex-wife (Maggie Carey) welcomed their first child, daughter Hannah Kathryn, on October 6, 2009. Their second daughter, Harper, was born on July 28, 2012 and third daughter, Hayley Clementine, on November 15, 2014.
- Father manages an air freight company. Mother is a dance teacher.
- His ex-wife, Maggie Carey, is a filmmaker who has won awards for both documentaries and narrative films.
- Is allergic to peanuts.
- Member of the sketch comedy group Animals from the Future.
- Dropped out of Scottsdale Community College.
- Attended Cascia Hall Prep School in Tulsa, Oklahoma.
- He has German, Danish, Irish, and English ancestry.
- Has two younger siblings.
- He has a severe peanut allergy.
- Was invited to join the actor's branch of the Academy of Motion Picture Arts & Sciences in 2023.
- He was interviewed by Tracy Smith on/for the March 31, 2019 broadcast of CBS News Sunday Morning (1979). The interview was filmed primarily on the Sony Pictures Studio lot in Culver City, California, USA, the studio and primary filming location for Hader's HBO sitcom, Barry (2018).
- Studied at the New York Film Academy College of Film, Media and Performing Arts (NYFA).
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