- Ancient student of L'Idhec.
- Brother of Fabrice Desplechin.
- Brother of writer Marie Desplechin.
- He began as cameraman for a friend, Eric Rochant, on the shooting of a short-film, "Comme les doigts de la main" ("Like hand's fingers"). Also for Rochant, he wrote the screenplay of "Un monde sans pitié" ("A Pitiless World").
- Brother of writer Raphaëlle Desplechin.
- Complete retrospective at the 40th Pesaro Film Festival; June 25th-July 3rd 2004, Pesaro (Italy)
- Complete retrospective at the Sala Trevi and Villa Medici; May 2006, Rome (Italy)
- Father of a son (born 2006).
- Member of the 'Official Competition' jury at the 69th Cannes International Film Festival in 2016.
- He directed 5 movies that were screened in competition at the Cannes Film Festival: The Sentinel (1992), Comment je me suis disputé... (ma vie sexuelle) (1996), Esther Kahn (2000), A Christmas Tale (2008) and Jimmy P. (2013). None of these movies received a single award from the jury.
- Member of the 'Official Competition' jury at the 67th Venice International Film Festival in 2010.
- As of 2022, 7 of his films have competed for the Palme d'Or in the official competition of the Cannes Film Festival: The Sentinel (1992), Comment je me suis disputé... (ma vie sexuelle) (1996), Esther Kahn (2000), A Christmas Tale (2008), Jimmy P. (2013), Oh Mercy! (2019), and Brother and Sister (2022). In 2017, his film Ismael's Ghosts (2017) was the opening film of the festival but it premiered out of competition.
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