- In 2003, when Shalhoub won the Emmy Award for his leading role of detective Adrian Monk, he dedicated the award to his nephew, 34-year-old Gregg Gensler, who passed away the day before.
- Was nominated for the 2009 Grammy Award for Best Spoken Word Album for Children for "The Cricket in Times Square".
- In 2005, upon winning his second Emmy Award for Monk (2002), he told his fellow nominees that "there's always next year". Ironically, Shalhoub was the only one of the five actors to be nominated the next year.
- His paternal grandparents, Milhelm and Mariam, both died during WWI, his grandfather at war and his grandmother likely from disease or hunger; half of the population of Mount Lebanon, where they resided, died between 1915 and 1918. His father subsequently came to Wisconsin as a child, where he was raised by Tony's mother's family, meeting Tony's mother. On the show Finding Your Roots with Henry Louis Gates, Jr. (2012), Tony also discovered that one of his maternal great-great-grandfathers, Abdul Neimy, was killed in the Hamidian massacres in 1895 by the Ottoman Empire.
- Received his Master's degree in Fine Arts from the Yale School of Drama in New Haven, Connecticut (1980).
- Is a huge fan of the NFL's Green Bay Packers and holds season tickets.
- Has two daughters with wife Brooke Adams: Josie Lynn (born 1988), who was adopted by Adams before her marriage and whom Shalhoub later adopted), and Sophie Shalhoub (born 1993), adopted by the couple after they married.
- Attended Yale University, where his friend, Jane Kaczmarek, followed him to after he had encouraged her to shoot for stardom. They had met earlier when they both attended the University of Wisconsin.
- Was the best man at Patricia Heaton's marriage to David Hunt.
- Spent four seasons with the American Repertory Theatre in Cambridge, Massachusetts.
- The ninth of ten children of Joseph and Helen (Seroogy) Shalhoub, both of whom were of Lebanese descent and adherents of the Maronite Church of Lebanon, an eastern arm of the Catholic Church. Tony's siblings include actors Michael Shalhoub and Susan Shalhoub Larkin. He is the brother-in-law of Lynne Adams. A cousin is Chicago/Los Angeles radio personality Jonathon Brandmeier.
- Nominated for the 2018 Emmy Award in the Supporting Actor in a Comedy Series category for his role as Abe Weissman in The Marvelous Mrs. Maisel (2017), but lost to Henry Winkler from Barry (2018).
- Was nominated for Broadway's 1992 Tony Award as Best Actor (Featured Role - Play) for Herb Gardner's "Conversations with My Father".
- Has worked both with the Coen Brothers (Barton Fink (1991), The Man Who Wasn't There (2001)) and their former cinematographer, Barry Sonnenfeld (Addams Family Values (1993), Men in Black (1997), Men in Black II (2002)).
- Keynote speaker at the class of 2003 graduation at the University of Southern Maine, his alma mater.
- Received his Bachelor's degree in Drama from the University of Southern Maine in Portland, Maine (1977).
- Surname is pronounced "SHUH-loob.".
- Has appeared with Cheech Marin in seven films: Paulie (1998), Spy Kids (2001), Spy Kids 2: Island of Lost Dreams (2002), Spy Kids 3: Game Over (2003), Cars (2006), Cars 2 (2011) and Cars 3 (2017).
- Attended and graduated from Green Bay East High School in Green Bay, Wisconsin (1972).
- In Men in Black (1997), he played Jeebs the pawnshop owner who is an alien disguised as human. Later, in Mr. Monk and the UFO (2009), his character was a human whom other people insisted was an alien in disguise.
- Friends with Patricia Heaton. Neighbors with Dean Parisot.
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