- [on why he chose to play Dr. McCoy instead of Mr. Spock on Star Trek (1966)] I wouldn't have been anywhere near Leonard Nimoy. He's marvelous.
- [on his life] I'd wanted to become a doctor and couldn't - yet became the best known doctor in the galaxy.
- [on the Star Trek (1966) fans] They're the most devoted group of people and contrary to what people think, they don't have antennae coming out of their heads.
- I'm very grateful for the career that I've had. And I'm very grateful for the experiences that Star Trek has afforded me along with my past background. When I look back and think how fortunate I've been to work with some wonderful people and had some marvelous experiences, then I can look at Star Trek and think it's almost like the cream on the coffee. I don't approach it as anything but a magnificent plus.
- I thoroughly enjoyed those years. I liked Westerns for two reasons: First, it took the actor outside. They were all very physical at that time and not limited to a stage. Second, they paid my rent an awful lot.
- [to William Shatner, on his deathbed] Let's make just one more Star Trek movie! I sure miss making those movies!
- [on why he turned down Star Trek: Generations (1994)]: When I read the script and saw we were only in the first 10 minutes, I thought it was best to pass and go out with 'VI' ('The Undiscovered Country'). At the time, I didn't know Leonard had passed as well, and I certainly wouldn't have done the film without him in it.
- [on the Star Trek episode 'The Deadly Years'] I once aged 90 years old in one episode.
- [on the process of working on a Star Trek episode] I'm up at 5 (a.m.) in the morning and in bed by 10 (p.m.) in the evening.
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