- Has been close friends with Brad Pitt since they both starred in Johnny Suede (1991) together, and they often attend each other's movie premieres.
- Catherine was devastated when famed author Harper Lee, whom she played in Capote (2005), refused to speak with her before filming. The author, who had been celebrated author Truman Capote's best friend since childhood, refused to cooperate with the making of the film. Lee did contact Keener after filming, to tell her that she enjoyed the film.
- Gave birth to her only child at age 40, a son Clyde Mulroney on June 21, 1999. Child's father is her ex-husband, Dermot Mulroney.
- Good friends with actress Jennifer Aniston.
- Catherine shielded a surprised Jennifer Aniston from a reporter on Today (1952). The pair appeared to talk about a movie that they were filming, Friends with Money (2006), when the questions started to turn personal on Aniston. The reporter was warned before taping, that all personal topics were "off limits", yet when the interview started, the reporter asked about Jennifer's wedding plans with actor Vince Vaughn. Catherine stepped in, and told the reporter to "back off" and stick to the topic at hand.
- As of 2017, has appeared in 3 films that were nominated for the Best Picture Oscar: Capote (2005), Captain Phillips (2013), and Get Out (2017).
- Played Harvey Keitel's wife in a deleted scene in Thelma & Louise (1991), now available for viewing on the special edition DVD extras.
- Graduated from Wheaton College in Norton, Massachusetts in 1983.
- Attended a Catholic high school, Monsignor Edward Pace High School, Miami, Florida.
- Grew up in Hialeah, Florida.
- Her father is of English, German, and Scottish descent. Her mother is of Lebanese ancestry. Catherine's patrilineal line traces back to Peter Keiner, a German immigrant whose surname was later changed.
- Was member of the dramatic jury at the Sundance Film Festival in 1997.
- Has worked with director/producer Spike Jonze four times and director Nicole Holofcener four times.
- Appeared in three films with Philip Seymour Hoffman: Capote (2005), Synecdoche, New York (2008) and A Late Quartet (2012).
- Graduated from Immaculate Conception in Hialeah, Florida
- Older sister of Elizabeth Keener.
- Had two movies pushed back from late 2008 to a release in 2009. Both The Soloist (2009) and Where the Wild Things Are (2009).
- Is often mistaken for actress Mimi Rogers.
- Ex-sister-in-law of Kieran Mulroney, Sean Mulroney, Conor and Moira Mulroney.
- Was in the movie Project Adam with Walker Scobell who went on to play Percy Jackson in the Disney+ show Percy Jackson. She played Sally Jackson, Percy's mother in the 2010 adaption of Percy Jackson & the Lightning Thief with Logan Lerman.
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