- Even after he got married, he had dinner with his mother at her house every Sunday night, from 1981 until her death in 2003.
- He was involved in a deadly car crash on vacation in Ireland with former girlfriend Jennifer Grey in which he was hurt and two passengers in the other car were killed.
- He was the first choice for the role of Alex P. Keaton on the sitcom Family Ties (1982), but he did not want to be committed to a long television run. The role eventually went to Michael J. Fox.
- Became a father for the first time at age 40 when his wife Sarah Jessica Parker gave birth to their son James Wilke Broderick on October 28, 2002.
- Became a father for the second and third time at age 47 when he and his wife Sarah Jessica Parker welcomed twin daughters Matilda Loretta Elwell and Tabitha Hodge Broderick via a surrogate on June 22, 2009.
- Made his feature film debut in Max Dugan Returns (1983), which was also the debut of Kiefer Sutherland.
- His sister Janet Broderick, a minister, performed at his and Sarah Jessica Parker's wedding ceremony. The ceremony took place at a Lower East Side synagogue.
- He was awarded a Star on the Hollywood Walk of Fame in a double ceremony with Nathan Lane at 6801 Hollywood Boulevard in Hollywood, California on January 9, 2006.
- He has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically significant": Ferris Bueller's Day Off (1986) and The Lion King (1994).
- Sang "I Can Only Give You Love" for wife Sarah Jessica Parker at her 40th birthday.
- Was introduced to wife Sarah Jessica Parker through her brother, Timothy Britten Parker.
- For his return to "The Producers" in December 2003-April 2004, he is being paid $100,000 a week.
- His father had Irish, with some English, ancestry. His mother's family was Jewish (from Germany and Poland).
- He did not get along with Cary Elwes while making the war drama Glory (1989).
- Studied with a famed 'Reiki master' in Brooklyn for many years. Reiki is a Japanese alternative healing technique in which a master channels the universe's 'Reiki' energy through touch, strengthening the patients own supply.
- He and his wife Sarah Jessica Parker had movies opening on the same day in the United States: December 16, 2005. His movie was The Producers (2005), her movie was The Family Stone (2005).
- (May 15, 2001) On Late Night with Conan O'Brien (1993), he denied a rumor that he bought Cary Grant's bathtub, though he did sit in it.
- Has won two Tony Awards: in 1983, as Best Actor (Featured Role - Play) for "Brighton Beach Memoirs"; and, in 1995, as Best Actor (Musical) for a revival of "How to Succeed in Business Without Really Trying". He was also nominated as Best Actor (Musical) in 2001 for "The Producers", the new Mel Brooks musical.
- He was awarded the 1982 Los Angeles Drama Critics Circle Award for Distinguished Performance in Leading Role for the play, "Brighton Beach Memoirs" at the Ahmanson Theatre in Los Angeles, California.
- Matthew and his family have a home in Donegal (Ireland) where they vacation annually.
- Son of actor James Broderick and Patricia Broderick.
- Broke his collarbone in a horse-riding accident in County Donegal, Ireland in August 2006. He ended up in Sligo Hospital, but was released a few hours later. His wife was with him at the hospital.
- Studied drama under Herbert Berghof at HB Studio in Greenwich Village, New York City.
- He was considered for the role of Douglas Quaid in Total Recall (1990), which went to Arnold Schwarzenegger.
- He turned down the role of Johnny Utah in Point Break (1991), which went to Keanu Reeves.
- He was awarded the 1983 Antoinette Perry (Tony) Award for Best Featured Actor in a Play for "Brighton Beach Memoirs", on Broadway in New York City.
- Has two older sisters: Martha Broderick, a therapist and Janet Broderick, a minister.
- Loves to play ping-pong with his childhood best friend, Kenneth Lonergan.
- Before voicing Simba in The Lion King (1994), he was considered for the role of Prince Eric in The Little Mermaid (1989).
- He was going to star opposite Steve Martin in Dirty Rotten Scoundrels (1988), until somebody realised that he would look like Steve Martin's grandson.
- Made his London West End debut in friend Kenneth Lonergan's "The Starry Messenger" with Elizabeth McGovern. (May 2019)
- He was considered for the role of Brad Hamilton in Fast Times at Ridgemont High (1982), which went to Judge Reinhold.
- During production of Deck the Halls (2006), he could often be heard saying to himself, "I've hit rock bottom".
- He was considered for the lead role of Bruce Wayne in Batman (1989), which went to Michael Keaton.
- He was considered for the role of Walter White on Breaking Bad (2008), which went to Bryan Cranston.
- He was originally cast opposite Sally Field in No Small Affair (1984), but dropped out when Martin Ritt suffered a heart attack.
- He was originally cast as Jeffrey Willis in The Flamingo Kid (1984), but dropped out. Matt Dillon replaced him.
- He was considered for the role Cedric the Bellman in Home Alone 2: Lost in New York (1992), which went to Rob Schneider.
- He was considered for the role of Steve Gray in The Incredible Burt Wonderstone (2013). The role went to Jim Carrey (his co-star in The Cable Guy (1996)).
- He turned down the role of Michael Boll in Bad Influence (1990), which went to James Spader.
- He was considered for the role of Homer Wells in The Cider House Rules (1999) during its early development. The role went to Tobey Maguire.
- He was originally cast as David Kahane in The Player (1992) when Sidney Lumet was directing. Vincent D'Onofrio replaced him.
- He turned down the lead role in the comedy drama Jeffrey (1995), which went to Steven Weber.
- He was considered for the role of Joel Goodson in Risky Business (1983), which went to Tom Cruise.
- Friends with Kristin Chenoweth.
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