- Keenan helped push his father Ed Wynn to become an actor.
- Introduced Steve McQueen and Lee Marvin to the power of Triumph motorcycles on a hill climb.
- Father of Ned Wynn with first wife Evie Wynn Johnson. Ned is the author of the funny but tragic autobiography, "We Will Always Live In Beverly Hills", which chronicled the wild life of a boy growing up with famous, divorced parents. It offers a fascinating and revealing look into his mother's eventual marriage to Van Johnson.
- Part of the reason for his eventual loss of hearing was due to the fact that he raced just about anything on land or water and most of the vehicles were loud and unmuffled. He was a regular feature in and around the Detroit, Michigan, area racing boats, cars and motorcycles, sometimes racing boats on the Detroit River (the border between the United States and Ontario, Canada).
- Suffered from tinnitus (a chronic ringing in the ears) during the last years of his life, forcing him to wear hearing aids. Appeared with them in a photo accompanying a 1983 "National Enquirer" article, where he personally warned young people to protect their hearing.
- In his later years, Wynn undertook a number of philanthropic endeavors and supported several charity groups. He was a long-standing active member of the Westwood Sertoma International service club in West Los Angeles, California.
- Was originally to play Perry White in Superman (1978), but had to drop out upon arriving in London for filming due to heart problems. The role went to Jackie Cooper.
- He has appeared in six films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Touch of Evil (1958), Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb (1964), Point Blank (1967), Once Upon a Time in the West (1968), Nashville (1975), & The Goonies (1985).
- He was uncle to The Hudson Brothers due to his marriage to Sharley (they are her nephews). Daughter Hilda was married to singer-songwriter Paul Williams from 1993-2004. Daughter Emily (February 13, 1960 - November 27, 1980) died at age 20 from cancer. Granddaughter Jessica Keenan Wynn (Edwina's daughter) is also a Broadway singer and actress.
- Following his death, he was interred along with his father Ed Wynn at Forest Lawn Memorial Park in Glendale, California, in the Great Mausoleum, Daffodil Corridor, Columbarium of the Dawn.
- Keenan's wife Evie Wynn Johnson was a young actress who toured with Katharine Cornell but gave up her career when she married Wynn.
- Appears in three Oscar Best Picture nominees: Since You Went Away (1944), Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb (1964) and Nashville (1975).
- Keenan Wynn was a performer in a USO troupe in the China-Burma-India Theater of Operations with Pat O'Brien and Paulette Goddard.
- Father of screenwriter Tracy Keenan Wynn.
- He was awarded a Star on the Hollywood Walk of Fame at 1515 Vine Street in Hollywood, California on February 8, 1960.
- Had appeared with Janet Leigh in six films: Angels in the Outfield (1951), It's a Big Country: An American Anthology (1951), Fearless Fagan (1952), Strictly for Pleasure (1958), Touch of Evil (1958) and House on Greenapple Road (1970).
- His daughter Emily Keenan Wynn died in 1980 at age 20 from Lupus.
- Grandson of Frank Keenan
- Appeared with Kurt Russell in two TV series: "The Travels of Jaimie McPheeters" (1964) and "The Quest" (1976). Ironically, Kurt's longtime partner, Goldie Hawn, was once married to Keenan's nephew, Bill Hudson.
- Keenan worked with nephews Bill, Mark and Brett Hudson on their 1982 movie, "Hysterical," playing a fisherman.
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