- Has a band under the name Got A Girl which consists of herself and Dan the Automator.
- Has 1 child: son Laurie McGregor (b. June 27, 2021) with husband, Ewan McGregor.
- Favorite movies include Sunset Blvd. (1950), and Fargo (1996). Being a huge horror movie fan her favorites are Rosemary's Baby (1968), Black Christmas (1974), Alien (1979), and The Shining (1980).
- She was considered for the role of Gwen Stacy in The Amazing Spider-Man (2012). The role eventually went to Emma Stone.
- Enjoys cooking, dancing, and singing.
- She is a second cousin, three times removed, of actress Ava Gardner, through her paternal grandfather, Ambler William Winstead. Mary Elizabeth's paternal great-great-great-great-grandparents, William Gardner and Cynthia Eliza Batts, were also Ava's paternal great-grandparents.
- Was separated from her husband of nearly 7 years Riley Stearns and later divorced. (May 2017)
- In 2009 she was chosen by Empire magazine as one of the 20 "young, talented, and really happening right now".
- Ranked #10 on Maxim's "Hottest Women of Horror Movies" list.
- Named as Hottest Girls of Comic-Con 2010.
- She is completely of English heritage.
- Is a Southern Baptist.
- Youngest of five children, four daughters and one son, of James Ronald Winstead and wife Betty Lou Knight.
- In July 2010 she announced her engagement to writer Riley Stearns in an interview on Spin.com and said she will be getting married in her fiancé's hometown of Austin, TX, in October 2010.
- Ranked #17 out of 101 for Men's Health 'Hottest Women of 2011'.
- Born to James Ronald Winstead and his wife Betty Lou Knight.
- Was 5 years-old when her famous distant cousin, Ava Gardner died. But they never got to meet each other.
- In 2007 she was chosen by Empire magazine as one of the 100 Sexiest Stars in film history (#100).
- Stepmother of Clara Mathilde McGregor, Esther Rose McGregor, Jamyan McGregor and Anouk McGregor via husband Ewan McGregor.
- Was featured in "The Women of GQ".
- Voted by TC Candler's 100 Most Beautiful Faces of 2008 [#100].
- Lands at #13 in Portrait Mag's Top 30 Under 30.
- Ranked #75 in FHM's 100 Sexiest Women of 2008.
- Ranked #88 in FHM's 100 Sexiest Women of 2009.
- Drove a Volkswagen Jetta in 2 films Final Destination 3 and 10 Cloverfield Lane.
- Maternal granddaughter of The Rev. Johnnie or Johnny Wilbur or Wilber Knight (b. North Carolina), Minister of the Pentecostal Christian Church of God (son of Wilbur or Wilber Lee Knight and wife Nancy or Lucy Bell Tucker and paternal grandson of John Robert Knight and wife Dorcus Elizabeth or M. Sparks) and wife Virgie Kathleen Strickland (b. North Carolina) (daughter of James Purdie Strickland and wife Mittie Elizabeth Horne, paternal granddaughter of Isaac Calvin Strickland and wife Idella Frances Warren of the Warren Coat of Arms and maternal granddaughter of John Franklin or Frank Horne and wife Martha Elizabeth Jolly).
- Paternal granddaughter of Ambler William "Jack" Winstead (b. North Carolina) (son of George William Alford Winstead and wife Rosa Berdie Wells, paternal grandson of George Washington Winstead and wife Rilda Annie or Anna Olive Gardner and maternal grandson of John Bernet Wells and wife Martha Williamanne Roberson) and wife Oveda Rochelle Proctor (b. North Carolina) (daughter of Walter Young Proctor and wife Eva Gertrude Bowden, paternal granddaughter of John F. Proctor and wife Lucy Jane Batchelor and maternal granddaughter of Benjamin Franklin Bowden and wife Sarah Elizabeth Batten).
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