- Brother Jeffrey Santos is also an actor who co-starred with her in a number of drama TV series.
- Has one brother and one sister.
- Ten percent of her income goes to finance project Touch A Heart foundation which helps the poor, battered women, sexually abused children. The foundation is being run by directors Joyce Bernal and Gilbert Perez.
- Partly owns Carabana Music Cafe.
- Mother is Carol Santos.
- At the Cinema One Originals Film Festival 2009, she received the Cinema One Legend Award.
- (April 28, 2009) Married her boyfriend of 4 years Ryan Agoncillo in a private wedding ceremony at San Juan de Nepomuceno Church in San Juan, Batangas.
- Her oldest child, an adopted daughter Johanna Louis Santos-Agoncillo with her husband Ryan Agoncillo, was born in 2005. She and her husband never kept it a secret that she was adopted from their daughter and all the family.
- Gave birth to her 2nd child at age 32, a son named Juan Luis-Santos Agoncillo on October 7, 2010 at the Asian Hospital and Medical Center in Alabang, Muntinlupa City. Child's father is her husband, Ryan Agoncillo.
- Her oldest child, an adopted daughter Johanna Louis Santos-Agoncillo with her husband Ryan Agoncillo, was born in 2005. She and her husband never kept it a secret from their daughter.
- Gave birth to her 3rd child at age 37, a daughter named Juana Luisa Agoncillo on January 8, 2016. Child's father is her husband, Ryan Agoncillo.
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