- Aged 19, he began a month-long trek from East to West Germany to escape Communism, during which he lost part of his finger to frostbite. He crossed 4 borders with nothing other than a passport and the equivalent of $100 in his possession.
- Has played a German nazi officer in 11 different, completely unrelated films: The Warrior's Heart (1992), Stalingrad (1993), U-571 (2000), The Pianist (2002), In Enemy Hands (2004), Downfall (2004), Head in the Clouds (2004), Adolf Eichmann (2007), Valkyrie (2008), The Sinking of the Laconia (2010) and Stalingrad (2013).
- Started working as an actor at the age of 25, after being trained to be an Olympic swimmer.
- Collaborated again with his The Pianist (2002) co-star Adrien Brody in King Kong (2005). Incidentally, both of Kretschmann's roles with Brody are as captains, albeit of a very different type. In The Pianist (2002), he played a Nazi officer with a conscience; in King Kong (2005) he plays a tough boat captain guiding a film crew.
- Now living and working in Los Angeles (2000)
- He played Count Dracula in Dracula 3D (2012) and his arch nemesis Professor Abraham Van Helsing in Dracula (2013).
- Modeled in Hugo Boss perfume advertisement.
- Was hired to voice Johan Krauss in Hellboy II: The Golden Army (2008) but Guillermo Del Toro considered that his voice and the mechanical noise of the character's suit didn't mesh well. The job went to Seth McFarlane.
- He has three children: two sons, Nicolas (born 1998) and Alexander 'Sascha' (born 2002), and one daughter, Stella (born 1999), with his ex-girlfriend, Lena Roklin.
- Made his stage debut in "Macbeth," directed by Katharina Thalbach.
- He starred in two World War II films with the same title: Stalingrad (1993) and Stalingrad (2013).
- Received the Max Ophüls Prize for best young actor in 1991.
- He has played a Nazi officer in 10 movies so far and, in Have No Fear: The Life of Pope John Paul II (2005), he played Pope John Paul II, who (as the movie shows) fought against and tried to protect people from the Nazis.
- Has a tattoo on his right calf.
- Considered buying a house in the Bahamas while filming Der Seewolf (2008) (aka The Sea Wolf).
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