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High school student Sho happens to come across a mysterious metal object that causes his body to become enveloped in a weapon-encrusted suit of armor, changing him into a being called The Guyver. The Chronos corporation, creators of the Guyver armor and an army of mutant soldiers called Zoanoids, will stop at nothing to get their secret product back, and begin murdering people close to Sho in order to bring him out of hiding. Meanwhile, the head Chronos' security has acquired a Guyver suit of her own, and is planning to hunt Sho down herself.

Sex Hotline Operator, Natsumi Rumi meets Sugiura Ryo a man who transforms into a vicious tentacled beast when he's aroused, now Rumi is dedicated to "cure" this man of his ailment. Not knowing that their is a dark secret circling around him.