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ENTRY	nt06031
Name	Citrate cycle and pyruvate metabolism
Category	Pathway view; Carbohydrate metabolism
Pathway	hsa00020 Citrate cycle (TCA cycle) hsa00620 Pyruvate metabolism
Module	hsa_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA hsa_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate hsa_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Disease	H00072 Pyruvate dehydrogenase complex deficiency H01022 Diseases of the tricarboxylic acid cycle
Display	drug-target relation   disease type

N01603    Pyruvate+Lipoyl-E2 − PDH ⇉ DLAT → AcCoA+Dihydrolipoy..     PDH E1-alpha deficiency     PDHA1*     PDH E1-beta deficiency     PDHB*     PDH E2 deficiency         DLAT* N01609    2OG+Lipoyl-E2 − OGDH ⇉ DLST → SucCoA+Dihydrolipo..     KGDHC deficiency     OGDH*     YOBELN     OGDHL* N01616    Dihydrolipoyl-E2 − DLD → Lipoyl-E2     DLD deficiency     DLD*   N01604    OA+AcCoA − (CS,ACLY) ⇉ ACO1/2 ⇉ IDH → 2OG     ICRD         ACO2*     D-2-HGA             IDH2* N01617    SucCoA − SUCL ⇉ SDH ⇉ FH ⇉ MDH1/2 → OA     SDH deficiency         SDHA*     SDH deficiency         SDHB*     SDH deficiency         SDHD*     FH deficiency             FH*   N01606    PEP − (PKLR,PKM) → Pyruvate     PK deficiency     PKLR*   N01605    Pyruvate − PC → OA − MDH1/2 ⇉ PCK1/2 → PEP     PC deficiency     PC*     PCKD                 PCK1*

		Disease name	Disease category
PDH E1-alpha deficiency	H01997	Pyruvate dehydrogenase E1-alpha deficiency	Inherited metabolic disorder
PDH E1-beta deficiency	H01998	Pyruvate dehydrogenase E1-beta deficiency	Inherited metabolic disorder
PDH E2 deficiency	H01999	Pyruvate dehydrogenase E2 deficiency	Inherited metabolic disorder
KGDHC deficiency	H02006	Alpha-ketoglutarate dehydrogenase complex deficiency	Inherited metabolic disorder, Mitochondrial disease
YOBELN	H02562	Yoon-Bellen neurodevelopmental syndrome	Inherited metabolic disorder, Mitochondrial disease
DLD deficiency	H02000	Dihydrolipoamide dehydrogenase deficiency	Inherited metabolic disorder
ICRD	H02113	Infantile cerebellar-retinal degeneration	Inherited metabolic disorder
D-2-HGA	H01225	D-2-hydroxyglutaric aciduria	Inherited metabolic disorder
SDH deficiency	H02005	Mitochondrial complex II deficiency	Inherited metabolic disorder, Mitochondrial disease
FH deficiency	H02004	Fumarase deficiency	Inherited metabolic disorder
PK deficiency	H01096	Pyruvate kinase deficiency	Inherited metabolic disorder
PC deficiency	H00073	Pyruvate carboxylase deficiency	Inherited metabolic disorder
PCKD	H02520	Phosphoenolpyruvate carboxykinase deficiency	Inherited metabolic disorder