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KEGG   Homo sapiens (human): 5914
Entry
5914              CDS       T01001                                 
Symbol
RARA, NR1B1, RAR, RARalpha
Name
(RefSeq) retinoic acid receptor alpha
  KO
K08527  retinoic acid receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04659  Th17 cell differentiation
hsa04915  Estrogen signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Disease
H02542  Acute promyelocytic leukemia
Drug target
Acitretin: D02754<US>
Alitretinoin: D02815<US>
Arsenic trioxide: D02106<JP/US>
Etretinate: D00316<JP>
Fenretinide: D04162
Isotretinoin (DG00434): D00348<US> D04636
Retinol (vit A) (DG00123): D00164<JP/US> D01621 D06543<JP> D08477
Tamibarotene: D01418<JP>
Tazarotene: D01132<US>
Tretinoin (DG00433): D00094<JP/US> D00094<JP/US> D01516<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    5914 (RARA)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    5914 (RARA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    5914 (RARA)
   05202 Transcriptional misregulation in cancer
    5914 (RARA)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    5914 (RARA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    5914 (RARA)
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors [BR:hsa03310]
    5914 (RARA)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    5914 (RARA)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1B. Retinoic acid receptor (RAR)
   5914 (RARA)
SSDB
Motif
Pfam: zf-C4 Hormone_recep
Other DBs
NCBI-GeneID: 5914
NCBI-ProteinID: NP_000955
OMIM: 180240
HGNC: 9864
Ensembl: ENSG00000131759
UniProt: P10276 Q6I9R7
Structure
LinkDB
Position
17:40309180..40357643
AA seq 462 aa
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggccagcaacagcagctcctgcccgacacctgggggcgggcacctcaatgggtacccg
gtgcctccctacgccttcttcttcccccctatgctgggtggactctccccgccaggcgct
ctgaccactctccagcaccagcttccagttagtggatatagcacaccatccccagccacc
attgagacccagagcagcagttctgaagagatagtgcccagccctccctcgccaccccct
ctaccccgcatctacaagccttgctttgtctgtcaggacaagtcctcaggctaccactat
ggggtcagcgcctgtgagggctgcaagggcttcttccgccgcagcatccagaagaacatg
gtgtacacgtgtcaccgggacaagaactgcatcatcaacaaggtgacccggaaccgctgc
cagtactgccgactgcagaagtgctttgaagtgggcatgtccaaggagtctgtgagaaac
gaccgaaacaagaagaagaaggaggtgcccaagcccgagtgctctgagagctacacgctg
acgccggaggtgggggagctcattgagaaggtgcgcaaagcgcaccaggaaaccttccct
gccctctgccagctgggcaaatacactacgaacaacagctcagaacaacgtgtctctctg
gacattgacctctgggacaagttcagtgaactctccaccaagtgcatcattaagactgtg
gagttcgccaagcagctgcccggcttcaccaccctcaccatcgccgaccagatcaccctc
ctcaaggctgcctgcctggacatcctgatcctgcggatctgcacgcggtacacgcccgag
caggacaccatgaccttctcggacgggctgaccctgaaccggacccagatgcacaacgct
ggcttcggccccctcaccgacctggtctttgccttcgccaaccagctgctgcccctggag
atggatgatgcggagacggggctgctcagcgccatctgcctcatctgcggagaccgccag
gacctggagcagccggaccgggtggacatgctgcaggagccgctgctggaggcgctaaag
gtctacgtgcggaagcggaggcccagccgcccccacatgttccccaagatgctaatgaag
attactgacctgcgaagcatcagcgccaagggggctgagcgggtgatcacgctgaagatg
gagatcccgggctccatgccgcctctcatccaggaaatgttggagaactcagagggcctg
gacactctgagcggacagccggggggtggggggcgggacgggggtggcctggcccccccg
ccaggcagctgtagccccagcctcagccccagctccaacagaagcagcccggccacccac
tccccgtga

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