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Homo sapiens (human): 4193
Help
Entry
4193 CDS
T01001
Symbol
MDM2, ACTFS, HDMX, LSKB, hdm2
Name
(RefSeq) MDM2 proto-oncogene
KO
K06643
E3 ubiquitin-protein ligase Mdm2 [EC:
2.3.2.27
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa01524
Platinum drug resistance
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04115
p53 signaling pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04144
Endocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04218
Cellular senescence
hsa04625
C-type lectin receptor signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa05131
Shigellosis
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05219
Bladder cancer
hsa05220
Chronic myeloid leukemia
Network
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06170
Influenza A virus (IAV)
nt06230
Cell cycle (cancer)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06273
Glioma
nt06276
Chronic myeloid leukemia
Element
N00066
MDM2-p21-Cell cycle G1/S
N00067
Deleted p14(ARF) to p21-cell cycle G1/S
N00068
Amplified MDM2 to p21-cell cycle G1/S
N00076
Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00131
Amplified MYCN to transcriptional activation
N00263
EBV EBNA3C to p53-mediated transcription
N00536
MDM2-p21-Cell cycle G1/S
Disease
H00025
Penile cancer
H00028
Choriocarcinoma
H00036
Osteosarcoma
H00037
Rhabdomyosarcoma
H00042
Glioma
H01513
Retinoblastoma
H01667
Medulloblastoma
Drug target
Brigimadlin:
D12842
Idasanutlin:
D11219
Milademetan (
DG03270
):
D12621
D12622
Navtemadlin:
D12378
Siremadlin (
DG03238
):
D12417
D12418
Sulanemadlin:
D12399
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
4193 (MDM2)
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
4193 (MDM2)
04151 PI3K-Akt signaling pathway
4193 (MDM2)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
4193 (MDM2)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
4193 (MDM2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4193 (MDM2)
05202 Transcriptional misregulation in cancer
4193 (MDM2)
05206 MicroRNAs in cancer
4193 (MDM2)
05205 Proteoglycans in cancer
4193 (MDM2)
05203 Viral carcinogenesis
4193 (MDM2)
09162 Cancer: specific types
05214 Glioma
4193 (MDM2)
05220 Chronic myeloid leukemia
4193 (MDM2)
05218 Melanoma
4193 (MDM2)
05219 Bladder cancer
4193 (MDM2)
05215 Prostate cancer
4193 (MDM2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
4193 (MDM2)
05169 Epstein-Barr virus infection
4193 (MDM2)
05165 Human papillomavirus infection
4193 (MDM2)
09171 Infectious disease: bacterial
05131 Shigellosis
4193 (MDM2)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
4193 (MDM2)
01522 Endocrine resistance
4193 (MDM2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
4193 (MDM2)
04121 Ubiquitin system [BR:
hsa04121
]
4193 (MDM2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
4193 (MDM2)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
4193 (MDM2)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Single Ring-finger type E3
MDM2/MDM4 proteins
4193 (MDM2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-C3HC4_3
Zn_ribbon_RanBP
SWIB
zf-RING_2
zf-FPG_IleRS
DUF7130
Motif
Other DBs
NCBI-GeneID:
4193
NCBI-ProteinID:
NP_002383
OMIM:
164785
HGNC:
6973
Ensembl:
ENSG00000135679
UniProt:
Q00987
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:68808172..68850686
Genome browser
AA seq
497 aa
AA seq
DB search
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
CPVCRQPIQMIVLTYFP
NT seq
1494 nt
NT seq
+upstream
nt +downstream
nt
atggtgaggagcaggcaaatgtgcaataccaacatgtctgtacctactgatggtgctgta
accacctcacagattccagcttcggaacaagagaccctggttagaccaaagccattgctt
ttgaagttattaaagtctgttggtgcacaaaaagacacttatactatgaaagaggttctt
ttttatcttggccagtatattatgactaaacgattatatgatgagaagcaacaacatatt
gtatattgttcaaatgatcttctaggagatttgtttggcgtgccaagcttctctgtgaaa
gagcacaggaaaatatataccatgatctacaggaacttggtagtagtcaatcagcaggaa
tcatcggactcaggtacatctgtgagtgagaacaggtgtcaccttgaaggtgggagtgat
caaaaggaccttgtacaagagcttcaggaagagaaaccttcatcttcacatttggtttct
agaccatctacctcatctagaaggagagcaattagtgagacagaagaaaattcagatgaa
ttatctggtgaacgacaaagaaaacgccacaaatctgatagtatttccctttcctttgat
gaaagcctggctctgtgtgtaataagggagatatgttgtgaaagaagcagtagcagtgaa
tctacagggacgccatcgaatccggatcttgatgctggtgtaagtgaacattcaggtgat
tggttggatcaggattcagtttcagatcagtttagtgtagaatttgaagttgaatctctc
gactcagaagattatagccttagtgaagaaggacaagaactctcagatgaagatgatgag
gtatatcaagttactgtgtatcaggcaggggagagtgatacagattcatttgaagaagat
cctgaaatttccttagctgactattggaaatgcacttcatgcaatgaaatgaatcccccc
cttccatcacattgcaacagatgttgggcccttcgtgagaattggcttcctgaagataaa
gggaaagataaaggggaaatctctgagaaagccaaactggaaaactcaacacaagctgaa
gagggctttgatgttcctgattgtaaaaaaactatagtgaatgattccagagagtcatgt
gttgaggaaaatgatgataaaattacacaagcttcacaatcacaagaaagtgaagactat
tctcagccatcaacttctagtagcattatttatagcagccaagaagatgtgaaagagttt
gaaagggaagaaacccaagacaaagaagagagtgtggaatctagtttgccccttaatgcc
attgaaccttgtgtgatttgtcaaggtcgacctaaaaatggttgcattgtccatggcaaa
acaggacatcttatggcctgctttacatgtgcaaagaagctaaagaaaaggaataagccc
tgcccagtatgtagacaaccaattcaaatgattgtgctaacttatttcccctag
DBGET
integrated database retrieval system