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KEGG   Homo sapiens (human): 2798
Entry
2798              CDS       T01001                                 
Symbol
GNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR
Name
(RefSeq) gonadotropin releasing hormone receptor
  KO
K04280  gonadotropin-releasing hormone receptor
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04912  GnRH signaling pathway
Network
nt06323  KISS1-GnRH-LH/FSH-E2 signaling
  Element
N00873  GnRH-GnRHR-PLCB-PKC signaling pathway
Disease
H00255  Hypogonadotropic hypogonadism
Drug target
Abarelix: D02738
Buserelin (DG00729): D01831<JP> D07259
Cetrorelix (DG00505): D01685<JP/US> D07665
Degarelix (DG00736): D08635 D08901 D09400<JP/US>
Elagolix (DG01345): D09335 D09336<US>
Fertirelin (DG01346): D07957
Ganirelix (DG00504): D04302<JP/US> D08010
Gonadorelin (DG00499): D00988 D03267<JP> D04361 D08027
Goserelin (DG00731): D00573<JP/US> D04405
Histrelin (DG00733): D02116<US> D02369
Iturelix: D04644
Leuprorelin (DG00730): D00989<JP/US> D08113 D12337<US>
Linzagolix (DG03061): D11608 D11609
Lutrelin acetate: D04823
Nafarelin (DG00500): D00990<JP/US> D08241
Opigolix: D11351
Prazarelix acetate: D05599
Relugolix: D10888<JP/US>
Triptorelin (DG00732): D06247 D06248<US> D08649
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2798 (GNRHR)
   04081 Hormone signaling
    2798 (GNRHR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    2798 (GNRHR)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Gonadotropin-releasing hormone (GnRH)
    2798 (GNRHR)
SSDB
Motif
Pfam: 7tm_1
Other DBs
NCBI-GeneID: 2798
NCBI-ProteinID: NP_000397
OMIM: 138850
HGNC: 4421
Ensembl: ENSG00000109163
UniProt: P30968
Structure
LinkDB
Position
4:complement(67737118..67754388)
AA seq 328 aa
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
NT seq 987 nt   +upstreamnt  +downstreamnt
atggcaaacagtgcctctcctgaacagaatcaaaatcactgttcagccatcaacaacagc
atcccactgatgcagggcaacctccccactctgaccttgtctggaaagatccgagtgacg
gttactttcttcctttttctgctctctgcgacctttaatgcttctttcttgttgaaactt
cagaagtggacacagaagaaagagaaagggaaaaagctctcaagaatgaagctgctctta
aaacatctgaccttagccaacctgttggagactctgattgtcatgccactggatgggatg
tggaacattacagtccaatggtatgctggagagttactctgcaaagttctcagttatcta
aagcttttctccatgtatgccccagccttcatgatggtggtgatcagcctggaccgctcc
ctggctatcacgaggcccctagctttgaaaagcaacagcaaagtcggacagtccatggtt
ggcctggcctggatcctcagtagtgtctttgcaggaccacagttatacatcttcaggatg
attcatctagcagacagctctggacagacaaaagttttctctcaatgtgtaacacactgc
agtttttcacaatggtggcatcaagcattttataactttttcaccttcagctgcctcttc
atcatccctcttttcatcatgctgatctgcaatgcaaaaatcatcttcaccctgacacgg
gtccttcatcaggacccccacgaactacaactgaatcagtccaagaacaatataccaaga
gcacggctgaagactctaaaaatgacggttgcatttgccacttcatttactgtctgctgg
actccctactatgtcctaggaatttggtattggtttgatcctgaaatgttaaacaggttg
tcagacccagtaaatcacttcttctttctctttgcctttttaaacccatgctttgatcca
cttatctatggatatttttctctgtga

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