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KEGG   Canis lupus familiaris (dog): 491130
Entry
491130            CDS       T01007                                 
Symbol
ACACA
Name
(RefSeq) acetyl-CoA carboxylase 1 isoform X1
  KO
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00061  Fatty acid biosynthesis
cfa00620  Pyruvate metabolism
cfa00640  Propanoate metabolism
cfa01100  Metabolic pathways
cfa01212  Fatty acid metabolism
cfa04152  AMPK signaling pathway
cfa04910  Insulin signaling pathway
cfa04922  Glucagon signaling pathway
cfa04936  Alcoholic liver disease
Module
cfa_M00082  Fatty acid biosynthesis, initiation
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    491130 (ACACA)
   00640 Propanoate metabolism
    491130 (ACACA)
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    491130 (ACACA)
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    491130 (ACACA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    491130 (ACACA)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    491130 (ACACA)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    491130 (ACACA)
Enzymes [BR:cfa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.15  acetyl-CoA carboxytransferase
     491130 (ACACA)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.14  biotin carboxylase
     491130 (ACACA)
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2  acetyl-CoA carboxylase
     491130 (ACACA)
SSDB
Motif
Pfam: ACC_central Carboxyl_trans CPSase_L_D2 ACCA_BT Biotin_carb_N Biotin_carb_C Biotin_lipoyl ATP-grasp Dala_Dala_lig_C ATP-grasp_3
Other DBs
NCBI-GeneID: 491130
NCBI-ProteinID: XP_005624832
Ensembl: ENSCAFG00000017996
VGNC: 37489
UniProt: A0A8C0RX08 A0A8I3N2K7
LinkDB
Position
9:complement(36128994..36412715)
AA seq 2383 aa
MWWSTLMSILRVSSFWRWISAQTVRIIRALRAHFERIMDEPSPLAKPLELNQHSRFIIGS
VSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGISSLQDGLALHMRSSMSGLH
LVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYE
MFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQ
AVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGS
GLRVDWHENDFSKRILNVPQELYEKGYVKDVDDGLKAAEEVGYPVMIKASEGGGGKGIRK
VNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRR
HQKIIEEAPAAIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQ
VEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDAPIDFENSAHVPCPRG
HVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSW
GENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQLNRIDTGWLDRLIAEKVQA
ERPDTMLGVVCGALHVADVSLRNSISNFLHSLERGQVLPAHTLLNTVDVELIYGGVKYVL
KVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTC
VFEKENDPSVLRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAAESGCIHYVK
RPGAALDPGCVIAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNV
MNGYCLPDPFFSSRVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMA
QYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHM
KAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTM
LIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESI
FLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYEL
NSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLD
NSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFCDSPPQSPTFPEAGHTSLYDEDKVPRD
EPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVEHGIRRLTFLVAQKDFRKQVNYE
VDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHL
YLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNN
TNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTG
KAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLL
QSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQG
QLVHMNRLPGGNEIGMVAWKMTLKSPEYPEGRDIIVIGNDITYRIGSFGPQEDLLFLRAS
ELARAEGIPRIFVAANSGARIGLAEEIRHMFHVAWVDPEDPYKGYKYLYLTPQDYKRVSA
LNSVHCEHVEDEGESRYKITDIIGKEEGLGAENLRGSGMIAGESSLAYDEIITISLVTCR
AIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHS
IVCDDFEGVFTVLHWLSYMPKNVRSLVPLLNSKDPIDRIIEFVPTKAPYDPRWMLAGRPH
PTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPAN
LDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKF
GAYIVDSLRECSQPVLVYIPPQAELRGGSWVVIDPTINPRHMEMYADRESRGSVLEPEGT
VEIKFRRKDLVKTMRRVDPVYIRLAERLGTPELSAAERKELENKLKEREEFLIPIYHQVA
VQFADLHDTPGRMQEKGVINDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQ
IQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEEDGVRSVIEENIKYISRDYVLKQ
IRSLVQANPEVAMDSIVHMTQHISPTQRAEVVRILSTMDSPST
NT seq 7152 nt   +upstreamnt  +downstreamnt
atgtggtggtccactctgatgtcaatcttgagggttagttctttttggaggtggatatct
gctcagacagtgagaattataagagctttgagagctcattttgaaagaataatggatgaa
ccatcccccttggccaaacctctggagctgaaccagcactcccgattcataattggttct
gtgtctgaagataactcagaggatgaaattagcaacctggtgaagctggatctcctggag
gagaaggagggctctctatcaccagcttctgttggctcagatacactttctgacttgggg
atctccagcctacaggacggcttggccttacacatgaggtccagcatgtctggcttgcat
ctagtgaagcaaggtcgagaccgaaagaaaatagactctcagcgagatttcactgtagct
tctccagcagaatttgttactcgttttgggggaaataaagtgattgagaaggttcttatt
gccaacaatggcattgcagcagtgaaatgcatgcggtctatccgtcgatggtcttatgag
atgtttcgaaatgaacgtgcaatccgatttgttgttatggtaacacctgaagacctgaaa
gccaatgcagaatacattaagatggcggatcactatgtgccagtgccaggaggaccaaat
aacaacaactatgcgaacgtggaattaattcttgatattgctaaaaggattcccgtacaa
gcagtgtgggctggctggggtcatgcttctgagaatcccaagctcccagaacttcttttg
aaaaatggcatcgccttcatgggccctccaagccaggccatgtgggctttgggggataag
attgcatcttctatagtggctcaaactgcaggtatcccaactcttccctggagtggcagt
ggtcttcgggtggactggcatgaaaatgatttttccaaacgtatcttaaatgttccccag
gaattatacgaaaaaggttatgtgaaggatgtggatgatgggctaaaggcagcggaggaa
gttggatatccagtaatgatcaaggcctcagaaggaggaggagggaaaggaatcagaaaa
gtcaacaatgcagatgatttccctaacctcttcagacaggttcaagctgaagtccctgga
tctcctatatttgtgatgagactagccaaacaatctcgtcatctggaggtacagatctta
gcagatcaatatggcaatgctatctctctctttggtcgtgactgctctgtacagcgcagg
catcagaagattattgaggaagcacctgctgctattgctactccagcagtatttgaacat
atggaacagtgtgctgtgaaacttgccaaaatggttggttatgtgagtgctgggactgtg
gaatacctctacagccaggatggaagcttctactttctggaactgaaccctcggctacag
gtggaacacccttgtacagagatggtggctgatgtcaacctccctgcagcacaactccag
attgccatggggatccctctgtacagaatcaaggatattcgtatgatgtatggggtatct
ccctggggtgatgctcccattgattttgaaaattctgctcacgttccttgcccaaggggc
catgttattgccgctcggatcactagtgaaaatccagatgagggttttaagcccagctca
ggaacagttcaggaactgaatttccgtagcaataagaatgtttggggttatttcagtgtt
gctgctgcagggggccttcatgaatttgctgattctcagtttggtcattgcttctcctgg
ggagaaaacagagaggaagcaatttcaaacatggtggtggctttgaaggagctgtctatt
cggggtgactttcgaaccacagttgaatacctcatcaaattgttggagactgaaagcttt
cagttgaatagaattgacaccggctggctggacagactgatagcagagaaagtacaggca
gagcgacctgacaccatgttgggagttgtttgtggggctctccatgtggcagatgtgagc
ctacggaatagcatctctaacttccttcattctttagaaaggggtcaagtccttcctgct
catacacttctgaatacagtagatgttgaacttatctatgggggagtcaaatatgtactt
aaggtgactcggcagtcccccaactcctatgtggtgatcatgaatggttcatgcgtagaa
gtagatgtgcatcggctcagtgatggagggttactcctgtcctatgatggcagcagttac
accacatacatgaaggaagaagtggatagatatcgtatcacaattggcaataagacctgt
gtgtttgagaaggaaaatgacccttcagtgttacgctcaccttctgctgggaagttaatc
cagtacattgtggaggatggaggccatgtgtttgctggccagtgctatgctgaaattgag
gtgatgaagatggtaatgaccttaacagctgcagagtctggctgtatccattatgtcaaa
cggcctggagcagctcttgaccctggctgtgtaatagccaaaatgcagttggacaacccc
agcaaggtccaacaggctgagcttcacacaggtagtctgccacggatccagagcactgca
ctcagaggcgagaagctccatcgagtgttccactatgtcctggataatctggtcaacgta
atgaatggatactgccttccagatcctttttttagcagcagggtaaaagactgggtagag
cggttgatgaagaccctcagagacccctcgttacctctcctagaattacaagatatcatg
accagtgtctctggccgtattccccccaatgttgagaagtctatcaagaaggaaatggcc
cagtatgccagcaatatcacatcagtcctctgtcagtttcccagccagcagattgccaac
atcctagatagccatgcagctacgttgaaccggaaatctgagcgggaagtctttttcatg
aacactcagagcattgtccagctggtacagagataccgaagtggcatccgaggccacatg
aaggctgtggtgatggatctgctgcggcagtacctgcgagtagagacacagttccagaat
ggtcactatgacaaatgtgtgtttgcccttcgagaagagaacaagagtgatatgaacact
gtactgaactatatcttctctcatgctcaagtcaccaagaagaatcttctggtcacaatg
cttattgatcagttgtgcggtagggaccctactctcactgatgagctgctgaatattctc
acagagctaactcaactcagtaagaccaccaatgccaaagtagcacttcgagcacgccag
gttcttattgcctcccatttgccatcatatgagcttcgccataaccaagtagagtctatc
ttcctttcagctattgacatgtatggacatcagttttgcattgagaacctgcagaaactc
atcttgtctgaaacatctatttttgatgtcctaccaaacttcttctatcacagcaaccag
gtagtgaggatggcagctctggaggtttatgttcgaagggcttatattgcctatgaactt
aacagcgtacaacatcgccaacttaaggacaacacctgtgtggtggaattccaattcatg
ctacccacatctcatccaaatagagggaacatccccacgctaaacagaatgtccttctcc
tccaacctcaaccactatggcatgactcatgtagctagtgtcagcgatgtgcttttggac
aactcattcactccaccatgtcaacggatgggcggaatggtctcttttcggactttcgaa
gattttgtcaggatctttgatgaagtgatgggctgcttctgtgattctccaccgcaaagc
cctacattccctgaggcaggtcacacatctctatacgatgaagacaaggtccccagggat
gaaccaattcacattctgaatgtggctatcaagactgactgtgatattgaggatgacaga
ctggcagctatgttcagagagtttacccaacaaaataaagctaccctggttgagcatggg
atacggcgccttactttcctggttgcacaaaaggatttcaggaaacaggtcaactatgag
gtggatcagagatttcatagagaatttcctaaatttttcaccttccgagcaagggataag
tttgaggaggatcgtatctatcgtcacctggaacctgccctcgctttccagttagagctg
aaccggatgagaaattttgaccttactgccattccatgtgctaatcataaaatgcatctg
tatcttggggcagccaaggtggaggtgggcacagaagtgacagactacaggttctttgtt
cgtgcaatcatcagacattctgatctggtcaccaaggaagcttcttttgaatacctacaa
aatgaaggggagaggctgcttctagaagccatggatgagttggaagttgcttttaacaat
acaaacgttcgcactgactgtaaccacatcttcctcaactttgtgcccacggtcatcatg
gacccatcaaagattgaggaatctgtgcggagcatggtaatgcgctatggaagtcggctg
tggaaattacgtgtcctccaggcagaactgaaaatcaacattcgcctgacaccaactgga
aaagcaattcccatccgcctcttcctgacaaacgagtctggctattacttggacatcagc
ttgtataaggaagtgactgactccaggacagcacagatcatgtttcaggcatatggagac
aaacagggaccattgcatggaatgttaatcaacactccatacgtcaccaaagacctgctt
caatcaaagagattccaggcacaatccttggggacaacatacatatatgatataccagag
atgtttcggcagtctctgatcaaactctgggagtctatgtccactcaagcatttcttcca
tcaccccccctgccttccgacatgctgacatatacggagctcgtgttggatgatcaaggt
cagctggtccacatgaacaggcttccaggaggaaatgagattggcatggtagcgtggaaa
atgacccttaaaagtcctgaatacccagaaggccgagatatcattgttattggcaatgac
atcacataccgaattgggtcctttgggccccaggaggatttgctgtttctcagagcttct
gagcttgccagggcagagggtatcccacgcatctttgtagcagccaacagtggagcaaga
attggactggcagaggaaattcgtcatatgtttcatgtagcctgggtagatcctgaggat
ccttacaagggatacaaatatttatatctgacccctcaggattataagagagtcagtgct
ctcaactctgtccattgtgaacatgtagaggacgaaggagaatccaggtacaagataact
gatattattgggaaggaagagggacttggagcagagaaccttcgaggctctggaatgatc
gctggagaatcctcattggcctatgatgagatcatcaccatcagcctggttacatgccgg
gccattgggattggagcttaccttgtccggctgggacagagaaccatccaggttgaaaat
tctcatttaattttgactggagctggagccctcaacaaagtccttgggcgggaagtatac
acctccaataaccagctcgggggcatccagatcatgcacaacaatggggtgacccacagc
attgtttgtgatgactttgaaggggttttcactgtcctgcactggctatcctacatgcct
aagaatgtgcgcagtttagttcctctcctgaactccaaggatcctatagatagaatcatc
gagtttgttcccacgaaggccccatacgatcctcgatggatgctagcaggccgccctcac
ccaactcagaaaggtcagtggctgagtggattttttgactatggctctttctcagagatc
atgcaaccctgggcacaaactgtggtggttggcagagccaggctaggaggaatacctgtg
ggagtagttgctgtagaaacccgaacagtggaactaagtatcccagccgatcctgcaaac
ctggattctgaagccaagataatccagcaggctggccaggtttggttcccagactctgcg
tttaagacctatcaggctatcaaggacttcaaccgtgaaggactgcctctgatggtcttt
gccaactggagaggcttctctggtgggatgaaagatatgtatgaccaagtgctgaagttt
ggtgcctatattgtggatagcttacgggagtgctcccagcctgtgctggtatacattcct
cctcaggctgagctccggggtggctcctgggttgtgattgaccccaccatcaacccccgg
catatggagatgtacgctgaccgagaaagcaggggatcagttctggagccagaagggaca
gtagaaatcaaattccgcagaaaggatctggtgaaaaccatgcgtcgggtggacccagtc
tacattcgcttggctgagcgattgggcaccccagagctcagcgcagctgagcggaaggag
ctggagaacaagttgaaggagcgggaggaattcctaattcccatttaccatcaggtagcc
gtgcagtttgctgacttgcacgacacaccaggccggatgcaggagaagggtgttattaat
gacatcctggattggaaaacatcccgtacctttttctattggcggctgaggcgtctcctg
ctggaggacctggtcaaaaagaaaatccacaatgccaacccagagctgaccgatggccag
atccaggccatgctacggcgctggtttgtagaagtggaaggaactgtgaaggcctacgtt
tgggacaataacaaggacctggtggagtggctggagaaacagctgaccgaggaagatggt
gttcgctcagtaatcgaggaaaacatcaaatatatcagcagagactatgtcctcaagcag
atccgcagcttggtacaggccaatcccgaggttgccatggactccatcgtccatatgact
cagcatatctcacccactcagcgagcagaagtcgtacggatcctctccacgatggactcc
ccttcaacgtag

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