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KEGG   REACTION: R00238
Entry
R00238                      Reaction                               
Name
acetyl-CoA:acetyl-CoA C-acetyltransferase
Definition
2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA
Equation
2 C00024 <=> C00010 + C00332
Reaction class
RC00004  C00010_C00024
RC00326  C00024_C00332
Enzyme
2.3.1.9         2.3.1.16
Pathway
rn00071  Fatty acid degradation
rn00280  Valine, leucine and isoleucine degradation
rn00310  Lysine degradation
rn00362  Benzoate degradation
rn00380  Tryptophan metabolism
rn00620  Pyruvate metabolism
rn00630  Glyoxylate and dicarboxylate metabolism
rn00650  Butanoate metabolism
rn00720  Other carbon fixation pathways
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00087  beta-Oxidation
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00373  Ethylmalonyl pathway
M00374  Dicarboxylate-hydroxybutyrate cycle
M00375  Hydroxypropionate-hydroxybutylate cycle
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.9
     R00238  2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA
    2.3.1.16
     R00238  2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.3.1.16
   R00391  Acyl-CoA <=> 3-Oxoacyl-CoA
    R00238  Acetyl-CoA <=> Acetoacetyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R00238
Orthology
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07513  acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
Reference
1  [PMID:25478839]
  Authors
Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.
  Title
The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.
  Journal
Acta Crystallogr D Biol Crystallogr 70:3212-25 (2014)
DOI:10.1107/S1399004714023827
Reference
2  [PMID:12535077]
  Authors
Campbell JW, Morgan-Kiss RM, Cronan JE Jr
  Title
A new Escherichia coli metabolic competency: growth on fatty acids by a novel anaerobic beta-oxidation pathway.
  Journal
Mol Microbiol 47:793-805 (2003)
DOI:10.1046/j.1365-2958.2003.03341.x
Reference
3  [PMID:22669882]
  Authors
Hu J, Baker A, Bartel B, Linka N, Mullen RT, Reumann S, Zolman BK.
  Title
Plant peroxisomes: biogenesis and function.
  Journal
Plant Cell 24:2279-303 (2012)
DOI:10.1105/tpc.112.096586
Other DBs
RHEA: 21039
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