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ORTHOLOGY: K00622
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Entry
K00622 KO
Symbol
nat
Name
arylamine N-acetyltransferase [EC:
2.3.1.5
]
Pathway
map00232
Caffeine metabolism
map00633
Nitrotoluene degradation
map00983
Drug metabolism - other enzymes
map01100
Metabolic pathways
map01110
Biosynthesis of secondary metabolites
map01120
Microbial metabolism in diverse environments
map05204
Chemical carcinogenesis - DNA adducts
Reaction
R07940
R08036
acetyl-CoA:2,4-diamino-6-nitrotoluene N-acetyltransferase
R08248
acetyl-CoA: isoniazid N-acetyltransferase
R08250
acetyl-CoA:acetylhydrazine N-acetyltransferase
R11902
acetyl-CoA:hydrazine N-acetyltransferase
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09110 Biosynthesis of other secondary metabolites
00232 Caffeine metabolism
K00622 nat; arylamine N-acetyltransferase
09111 Xenobiotics biodegradation and metabolism
00633 Nitrotoluene degradation
K00622 nat; arylamine N-acetyltransferase
00983 Drug metabolism - other enzymes
K00622 nat; arylamine N-acetyltransferase
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
K00622 nat; arylamine N-acetyltransferase
Enzymes [BR:
ko01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.5 arylamine N-acetyltransferase
K00622 nat; arylamine N-acetyltransferase
BRITE hierarchy
Other DBs
COG:
COG2162
GO:
0004060
Genes
HSA:
10
(NAT2)
9
(NAT1)
PTR:
464023
(NAT1)
464024
(NAT2)
PPS:
100990661
(NAT2)
100991667
(NAT1)
GGO:
101150362
(NAT1)
101152545
(NAT2)
PON:
100435042
(NAT1)
129060827
(NAT2)
PPYG:
129043088
(NAT1)
129043091
(NAT2)
NLE:
100580331
(NAT1)
100580987
(NAT2)
HMH:
116472373
(NAT2)
116473764
(NAT1)
SSYN:
129486608
(NAT1)
129491107
(NAT2)
MCC:
704019
(NAT1)
704357
(NAT2)
MCF:
102119914
(NAT1)
102121561
MTHB:
126961452
126961453
MNI:
105482132
(NAT2)
105482138
CSAB:
103215401
(NAT1)
103215403
(NAT2)
CATY:
105601399
(NAT1)
105601400
(NAT2)
PANU:
101009542
(NAT1)
101010131
TGE:
112630309
(NAT2)
112630315
(NAT1)
MLEU:
105539373
(NAT1)
105539376
(NAT2)
RRO:
104655225
104655226
RBB:
108526475
108526477
TFN:
117092730
(NAT1)
117092749
PTEH:
111545658
111545783
(NAT2)
CANG:
105506650
(NAT1)
105506651
(NAT2)
CJC:
100397995
(NAT1)
SBQ:
101045716
(NAT1)
101047286
(NAT2)
CIMI:
108311997
(NAT1)
108312024
ANAN:
105705356
(NAT1)
CSYR:
103262334
103263194
MMUR:
105882540
105882541
105882543
LCAT:
123626451
123626489
PCOQ:
105825236
105825299
OGA:
100944436
100964262
100964577
MMU:
17960
(Nat1)
17961
(Nat2)
17962
(Nat3)
MCAL:
110300118
110300659
110300688
MPAH:
110336889
110336987
110337099
RNO:
116631
(Nat1)
116632
(Nat2)
290681
(Nat3)
MCOC:
116069400
116071440
116071442
ANU:
117721345
117721637
117721644
117721781
117722081
ASYL:
127668461
127668796
127668798
MUN:
110564517
110564518
110564521
CGE:
100689282
(Nat2)
100755335
MAUA:
101840278
(Nat1)
101840555
(Nat2)
PROB:
127220208
127220209
PLEU:
114703125
114703126
114703138
MORG:
121462774
121463089
121463146
MFOT:
126513742
126513743
126513749
AAMP:
119812563
119813085
119813102
NGI:
103745801
103745803
103745813
CPOC:
100723784
100724067
(Nat1)
100724343
CCAN:
109680577
109701090
109701091
DORD:
105991867
105992221
105992232
DSP:
122126233
122126857
122126940
PLOP:
125339574
NCAR:
124983865
124983866
MMMA:
107153956
107153957
ITI:
101967579
101967864
OCU:
100008974
(NAT2)
100328959
(NAT1)
OPI:
101523061
101527236
TUP:
102486411
(NAT1)
102487228
GVR:
103581914
AML:
100480317
UMR:
103677031
UAH:
113245585
UAR:
123780321
ELK:
111156822
LLV:
125092831
MPUF:
101671731
MNP:
132006506
MLK:
131820345
NVS:
122889838
ORO:
101367643
EJU:
114224832
ZCA:
113924821
118356728
MLX:
118009895
NSU:
110573124
LWW:
102735960
FCA:
101095575
PYU:
121044338
PCOO:
112858633
PBG:
122472729
PVIV:
125163242
LRUF:
124520911
PTG:
102955781
(NAT1)
PPAD:
109262233
PUC:
125923850
AJU:
106976139
HHV:
120233984
BTA:
512603
(NAT1)
BOM:
102275700
BIU:
109553540
BBUB:
102403863
BBIS:
104993240
CHX:
102169935
OAS:
101120889
(NAT1)
BTAX:
128068387
CSUM:
138078417
ODA:
120865875
(NAT1)
CCAD:
122432509
MREE:
136176713
MBEZ:
129549450
SSC:
100511905
CFR:
102510309
CBAI:
105071173
CDK:
105086440
VPC:
102525084
102532768
BACU:
102999256
BMUS:
118889524
LVE:
103082317
OOR:
101280132
DLE:
111173572
PCAD:
102994472
112061838
PSIU:
116746861
NASI:
112408499
ECB:
100049837
EPZ:
103540532
EAI:
106833608
MYD:
102752765
(NAT1)
102753338
102760162
MMYO:
118651804
118651805
118651806
118652085
MLF:
102423110
102423981
102426077
102432866
102433484
102433788
MDT:
132226430
132228582
132228583
PKL:
118729707
118730409
118730410
EFUS:
103288199
103288200
MNA:
107523940
DRO:
112308289
112321515
112321529
SHON:
118984275
AJM:
119038484
119046537
119047229
PDIC:
114508650
114508709
PHAS:
123807498
123807795
MMF:
118622555
PPAM:
129064672
RFQ:
117021026
PGIG:
120607072
PVP:
105310958
105311124
105311126
105311249
105311413
RAY:
107503880
MJV:
108388000
108401168
TOD:
119256975
LAV:
100677179
100677461
100677744
TMU:
101354440
101354690
ETF:
101645644
DNM:
101444633
MDO:
100027666
GAS:
123237038
123253986
123256592
SHR:
100919466
AFZ:
127548676
PCW:
110212707
TVP:
118841645
PBRV:
138149217
OAA:
100077007
GGA:
396283
(PNAT10)
396537
(NAT)
415809
(PNAT3)
PCOC:
116244056
116244057
116244058
MGP:
100548608
100548761
100549991
CJO:
107319387
107319388
107319389
TPAI:
128082059
128082061
128082062
LMUT:
125699048
125699049
125699050
(NAT1)
NMEL:
110404203
110404204
110404205
(NAT1)
APLA:
101791461
101791654
101791850
ACYG:
106044860
106044861
106044862
CATA:
118246522
118246524
126913100
AFUL:
116494024
116494025
116494216
TGU:
100218405
100222183
100225095
115490547
(NAT1)
LSR:
110476354
110476355
110476356
(NAT1)
SCAN:
103816733
103816734
103816736
PMOA:
120506955
120507956
120507957
120507958
OTC:
121334052
121334053
121334054
PRUF:
121348889
121348890
121348891
GFR:
102038858
102039206
102040232
FAB:
101810372
(NAT1)
101810563
101810753
OMA:
130257723
130257724
130257725
PHI:
102102516
102102700
102102890
PMAJ:
107209900
107209901
107209902
CCAE:
111934448
(NAT1)
111934450
111934451
CCW:
104691827
104691828
104691831
(NAT1)
CBRC:
103620104
(NAT1)
103620105
103620106
ACOE:
138117176
138117177
138117178
ETL:
114060984
114060995
114060998
114061034
114061043
114072393
114072394
ZAB:
102065473
102065658
102065843
102066138
ZLE:
135452954
135452955
135452956
135452957
ACHL:
103804389
103804390
103804391
SVG:
106852083
106852084
106852085
(NAT1)
MMEA:
130577276
130577277
130577278
HRT:
120757677
120757679
120757680
SATI:
136366468
136366469
136366470
FPG:
101913996
101915036
101915205
FCH:
102049096
102049271
102058986
CCRI:
104154561
104155316
104157136
NNT:
104403771
104403772
104403773
SHAB:
115619602
115619603
115619604
ACUN:
113484381
113484382
113484384
113484499
TALA:
104357345
104357346
104357347
ACHC:
115345663
115345664
115345665
HALD:
104318014
104318015
104318016
HLE:
104839379
104839380
104839381
AGEN:
126041009
126041010
126041011
HHAR:
128145664
128145665
128145666
(NAT1)
GCL:
127021161
127021236
127021288
CSTI:
104559015
104559016
104559018
LDI:
104339725
104340115
104340225
104340516
MNB:
103777207
103777208
103777210
DPUB:
104300826
104300827
104300853
PPUS:
135184344
135184345
135184346
AVIT:
104271546
104271553
104271560
BRHI:
104502124
104502125
104502126
EGZ:
104133744
104133745
104133747
NNI:
104014602
104014613
104014733
PCRI:
104035480
104035481
104035483
PCAO:
104039455
104045893
104045894
PADL:
103923868
103923870
103923871
AFOR:
103897303
103897304
103897305
FGA:
104069109
104070059
104072378
GSTE:
104254174
104254175
104254176
CLV:
102085619
(NAT1)
102086109
106145649
MUI:
104533194
104533262
104534016
PGUU:
104457474
104457553
104458470
PLET:
104623649
104623650
104623651
EHS:
104513556
104513557
104513558
CMAC:
104479291
104479292
104479293
CUCA:
104059382
104059383
104059384
TEO:
104384680
104384691
104384698
BREG:
104639886
104639887
104639888
OHA:
104339200
104339201
104339202
ACAR:
104517457
104518346
104520000
CPEA:
104396361
104396362
104396363
CVF:
104291175
104291176
104291177
RTD:
128908553
128908554
128908555
AAM:
106483271
106483273
106483274
106483355
AROW:
112962676
112962682
112962715
NPD:
112949882
112949883
112949884
TGT:
104567368
104567369
104567370
DNE:
112978850
112978870
112978871
SCAM:
104149333
104149334
104149335
ASN:
102378789
102379045
102379284
AMJ:
102574773
102575009
102575242
CPOO:
109310363
109310654
109310655
GGN:
109289318
109289459
109289460
PSS:
102453745
102457700
CMY:
102931077
CCAY:
125620893
(NAT1)
DCC:
119841141
CPIC:
101940914
101950692
112059549
TST:
117886635
117886745
CABI:
116816708
116816709
MRV:
120384422
120384755
ACS:
100565208
100565405
ASAO:
132782918
PVT:
110090098
SUND:
121937445
PBI:
103059580
PMUR:
107287706
CTIG:
120312148
TSR:
106544720
PGUT:
117670905
APRI:
131184232
PTEX:
113445044
NSS:
113432006
113432190
VKO:
123022336
123022377
PMUA:
114602208
114602209
PRAF:
128419441
128419442
ZVI:
118086513
118086514
HCG:
128334422
128334521
GJA:
107109832
107109835
(NAT1)
STOW:
125424946
125442403
EMC:
129344101
129344172
129344230
NPR:
108786559
RTEM:
120917951
MUO:
115458623
115469905
115470904
GSH:
117359629
(NAT1)
DRE:
445194
(zgc:101040)
449801
(zgc:103601)
794381
(si:dkey-78a14.4)
795256
(si:dkey-78a14.5)
SRX:
107715136
107722424
107738535
SANH:
107679010
107692750
107696680
SGH:
107551480
107588554
CCAR:
109093152
109098442
CAUA:
113061297
113078644
113095182
113106067
113106068
113118583
CGIB:
127934489
127949349
127962690
127962693
127977538
PTET:
122349706
122363038
122363039
LROH:
127167916
127180534
(zgc:101040)
OMC:
131524455
(zgc:101040)
131543707
131544392
PPRM:
120468823
120473881
RKG:
130069731
130077737
(zgc:101040)
MAMB:
125254297
(zgc:101040)
125265051
(zgc:103601)
CIDE:
127499905
(zgc:101040)
127515493
CERY:
137022595
(zgc:101040)
137031334
(zgc:103601)
MASI:
127417039
(zgc:101040)
127446442
127453914
TROS:
130563177
130563245
TDW:
130435750
130435786
MANU:
129419780
(zgc:101040)
129444933
IPU:
100528628
(ary1)
108259233
108259370
108259371
IFU:
128602852
128602853
128602855
PHYP:
113540997
113540999
SMEO:
124379781
124379782
124379783
124379784
124380209
TFD:
113656370
113656372
113656374
TVC:
132838727
132838733
132838994
TRN:
134304214
AMEX:
103021503
103022041
103025468
CMAO:
118817416
118817417
118817670
EEE:
113576704
113576721
113576722
CHAR:
105901338
105907209
SPIL:
134069288
134069293
134069299
LCO:
104920774
NCC:
104955050
TBEN:
117496663
117496691
117496694
117496705
PGEO:
117441194
117441204
GACU:
117549051
117549058
EMAC:
134863556
ELY:
117251663
117252379
EFO:
125878937
125878942
125878950
PLEP:
121939460
121940038
SLUC:
116037558
ECRA:
117952649
ESP:
116688385
PFLV:
114558570
GAT:
120812918
120834089
PPUG:
119221143
119226185
119226194
AFB:
129104588
CLUM:
117728759
PSWI:
130192663
CANA:
137786917
CVE:
137887500
137887513
137887581
137887630
MSAM:
119889962
119890093
SCHU:
122864443
CUD:
121514049
121515489
SPUL:
138589585
138593019
LMIX:
132979992
ALAT:
119018174
MZE:
101481779
101482061
ONL:
100704032
100704303
(nat1)
OAU:
116325620
116325644
OLA:
101157683
101165718
OML:
112160719
112160720
CSAI:
133421465
133463896
XMA:
102230777
(nat1)
XCO:
114142912
XHE:
116718490
116718491
PRET:
103462640
103462641
PFOR:
103138061
103138062
PLAI:
106957721
106957722
PMEI:
106927342
(nat1)
GAF:
122847283
PPRL:
129364259
129364260
CVG:
107088494
CTUL:
119781943
(si:dkey-78a14.4)
GMU:
124867200
124867201
124867202
NFU:
107373583
107382082
KMR:
108243328
ALIM:
106536371
NWH:
119430146
AOCE:
111572268
EJA:
138213255
138213425
138213430
138213431
BFRE:
138616153
138616225
MCEP:
125005824
125005825
CSEM:
103383261
SSEN:
122772820
(si:dkey-78a14.4)
LCF:
108876876
108877018
SDU:
111217696
(nat1)
SLAL:
111672246
111672358
XGL:
120794177
HCQ:
109514002
SBIA:
133498172
133498365
PEE:
133397884
PTAO:
133474151
BPEC:
110171948
110175435
110175484
MALB:
109954313
109955857
109955859
109955860
BSPL:
114852283
114852644
121201626
SJO:
128356562
128357018
SSCO:
133981405
133981413
SASA:
106562381
(ARY1)
106587573
(ARY1)
STRU:
115167037
115203284
OTW:
112249348
121842893
OMY:
110526592
OGO:
124033090
ONE:
115111137
OKI:
109881655
OKE:
118382098
SALP:
111969532
111974736
SNH:
120056583
CCLU:
121534753
123487512
ELS:
105025705
SFM:
108932932
108932960
PKI:
111832738
AANG:
118214903
118214904
118214905
118214923
CCOG:
133111706
133111975
133112025
133112080
133112100
LOC:
102689755
PSPA:
121296609
121325857
ARUT:
117424387
117425908
117425909
PSEX:
120535561
CMK:
103172656
RTP:
109923912
CPLA:
122545466
HOC:
132826407
SCLV:
120325539
120326277
120348690
DSV:
119462240
119462542
CCAC:
CcaHIS019_0302480
(CcaverHIS019_0302480)
BEQ:
BEWA_013780
SPPH:
KFK14_00460
MTU:
Rv3566c
(nat)
MTV:
RVBD_3566c
MTC:
MT3671
(nhoA)
MRA:
MRA_3605
(nat)
MTF:
TBFG_13599
MTB:
TBMG_03605
MTK:
TBSG_03632
MTZ:
TBXG_003580
MTG:
MRGA327_22015
MTI:
MRGA423_22535
MTE:
CCDC5079_3307
MTUR:
CFBS_3782
(nat)
MTL:
CCDC5180_3259
MTO:
MTCTRI2_3630
(nat)
MTD:
UDA_3566c
(nat)
MTN:
ERDMAN_3911
(nat)
MTJ:
J112_19200
MTUB:
MT7199_3628
MTUC:
J113_24975
MTUE:
J114_19070
MTX:
M943_18330
MTUH:
I917_25040
MTUL:
TBHG_04161
MTUT:
HKBT1_3767
(nat)
MTUU:
HKBT2_3776
(nat)
MTQ:
HKBS1_3779
(nat)
MBO:
BQ2027_MB3596C
(nat)
MBB:
BCG_3630c
(nat)
MBT:
JTY_3631
(nat)
MBM:
BCGMEX_3628c
(nat)
MBK:
K60_037040
MAF:
MAF_35780
(nat)
MMIC:
RN08_3943
MCE:
MCAN_35771
(nat)
MCQ:
BN44_110058
(nat)
MCV:
BN43_90064
(nat)
MCX:
BN42_90063
(nat)
MCZ:
BN45_100065
(nat)
MORY:
MO_003723
(nat)
MPA:
MAP_0501
(nhoA)
MAO:
MAP4_3366
MAVI:
RC58_16695
MAVU:
RE97_16730
MAV:
MAV_0595
MIT:
OCO_05040
MIA:
OCU_05080
MID:
MIP_00946
MYO:
OEM_05100
MCHI:
AN480_02515
MIR:
OCQ_05190
MMAL:
CKJ54_02455
MMAN:
MMAN_47990
(nat)
MSER:
MTY59_24340
(nat)
MSA:
Mycsm_00165
MUL:
MUL_4131
(nat)
MMI:
MMAR_5055
(nat)
MMAE:
MMARE11_48700
(nat)
MLI:
MULP_05313
(nat)
MPSE:
MPSD_52550
(nat)
MSHO:
MSHO_05370
(nat)
MMC:
Mmcs_0211
MKM:
Mkms_0221
MJL:
Mjls_0201
MMM:
W7S_02460
MKN:
MKAN_12065
MYV:
G155_01320
MHAD:
B586_04480
MFJ:
MFLOJ_40720
(nat)
MSTO:
MSTO_44690
(nat)
MSIM:
MSIM_29140
(nat)
MSAK:
MSAS_29110
(nat)
MKU:
I2456_25660
MLW:
MJO58_25065
MNV:
MNVI_19580
MPAG:
C0J29_27735
MNM:
MNVM_16320
MGOR:
H0P51_25790
MCOO:
MCOO_27240
(nat)
MBAI:
MB901379_04445
(nat)
MSEO:
MSEO_34500
(nat)
MGAU:
MGALJ_47190
MLJ:
MLAC_47380
(nat)
MBRD:
MBRA_12980
MSHJ:
MSHI_38690
(nat)
MMAM:
K3U93_22670
MSPG:
F6B93_20470
MOT:
LTS72_27935
MPAA:
MKK62_02425
MKY:
IWGMT90018_57440
(nat)
MADI:
A7U43_01145
MWU:
PT015_15540
MYW:
BVC93_15365
MYJ:
BCA37_27420
MSM:
MSMEG_0306
MSG:
MSMEI_0299
(nat)
MSB:
LJ00_01535
MSN:
LI99_01535
MSH:
LI98_01535
MVA:
Mvan_0235
MGI:
Mflv_0433
MSP:
Mspyr1_03210
MNE:
D174_02890
MYN:
MyAD_02825
MFT:
XA26_02810
MRH:
MycrhN_1510
MCHT:
MCHIJ_07140
MAUU:
NCTC10437_00240
(nat)
MFX:
MFAL_05890
MALV:
MALV_32910
MTY:
MTOK_10520
MARZ:
MARA_36070
MGAD:
MGAD_45510
MMAT:
MMAGJ_18890
MBOK:
MBOE_15090
MFG:
K6L26_30050
MSEI:
MSEDJ_15380
MFLV:
NCTC10271_04893
(nat)
MCEE:
MCEL_30040
MBRM:
L2Z93_002188
MMON:
EWR22_01155
MGO:
AFA91_08360
MHOL:
K3U96_25400
MSEN:
K3U95_01405
MRF:
MJO55_01130
MDF:
K0O62_01880
MAUS:
JN090_18770
MFRE:
EXE63_13665
MKR:
MKOR_28740
MPAK:
MIU77_17755
MJD:
JDM601_0190
(nat)
MMIN:
MMIN_19310
MHIB:
MHIB_33190
MHER:
K3U94_01120
MVM:
MJO54_00975
GOM:
D7316_01282
(nat)
GAM:
GII34_13175
GPD:
GII33_12405
GMG:
NWF22_23505
TSD:
MTP03_45680
» show all
Taxonomy
UniProt
Reference
PMID:
19014350
Authors
Lack NA, Kawamura A, Fullam E, Laurieri N, Beard S, Russell AJ, Evangelopoulos D, Westwood I, Sim E
Title
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.
Journal
Biochem J 418:369-78 (2009)
DOI:
10.1042/BJ20082011
Sequence
[mtu:
Rv3566c
]
Reference
PMID:
2340091
Authors
Blum M, Grant DM, McBride W, Heim M, Meyer UA
Title
Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.
Journal
DNA Cell Biol 9:193-203 (1990)
DOI:
10.1089/dna.1990.9.193
Sequence
[hsa:
9
]
LinkDB
All DBs
DBGET
integrated database retrieval system