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KEGG   DRUG: Danicopan
Entry
D11641                      Drug                                   
Name
Danicopan (JAN/USAN/INN);
Voydeya (TN)
Product
VOYDEYA (Alexion Pharmaceuticals)
Formula
C26H23BrFN7O3
Exact mass
579.1030
Mol weight
580.41
Structure
Remark
Therapeutic category: 3999
ATC code: L04AJ09
Product: D11641<JP/US>
Efficacy
Complement factor D inhibitor
  Disease
Paroxysmal nocturnal hemoglobinuria [DS:H01053]
Comment
Treatment of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases
Target
CFD [HSA:1675] [KO:K01334]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AJ Complement inhibitors
     L04AJ09 Danicopan
      D11641  Danicopan (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   Complement Inhibitors
    Danicopan
     D11641  Danicopan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D11641  Danicopan (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    CFD
     D11641  Danicopan (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11641
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11641
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11641
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11641
Other DBs
CAS: 1903768-17-1
PubChem: 405226508
ChEBI: 231416
LinkDB
KCF data

ATOM        38
            1   C8x C    10.3600  -18.1300
            2   C8y C    10.3600  -19.5300
            3   C8x C    11.5500  -20.2300
            4   C8y C    12.8100  -19.5300
            5   C8y C    12.8100  -18.1300
            6   C8x C    11.5500  -17.4300
            7   C8y C    14.1400  -19.9500
            8   N5x N    14.9100  -18.8300
            9   N4y N    14.1400  -17.7100
            10  C5a C    14.5600  -21.2800
            11  C1a C    15.9600  -21.5600
            12  O5a O    13.6500  -22.3300
            13  C8y C     9.1700  -20.2300
            14  C8x C     7.9800  -19.5300
            15  N5x N     6.7200  -20.2300
            16  C8y C     6.7200  -21.6300
            17  N5x N     7.9100  -22.3300
            18  C8x C     9.1700  -21.6300
            19  C1a C     5.5300  -22.3300
            20  C1b C    14.5600  -16.3800
            21  C5a C    15.9600  -16.1000
            22  N1y N    16.8700  -17.1500
            23  O5a O    16.3800  -14.7700
            24  C1x C    16.5900  -18.5500
            25  C1y C    17.8500  -19.2500
            26  C1x C    18.8300  -18.2700
            27  C1y C    18.2700  -17.0100
            28  C8x C    21.8400  -14.9100
            29  C8y C    21.8400  -16.3100
            30  N5x N    23.0300  -17.0100
            31  C8y C    24.2900  -16.3100
            32  C8x C    24.2900  -14.9100
            33  C8x C    23.0300  -14.2100
            34  X   Br   25.4800  -17.0100
            35  N1b N    20.6500  -17.0100
            36  C5a C    19.4600  -16.3100
            37  O5a O    19.4600  -14.9100
            38  X   F    18.0442  -20.6365
BOND        42
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    7  10 1
            12   10  11 1
            13   10  12 2
            14    2  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   16  19 1
            22    9  20 1
            23   20  21 1
            24   21  22 1
            25   21  23 2
            26   22  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   22  27 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   28  33 1
            37   31  34 1
            38   29  35 1
            39   35  36 1
            40   27  36 1 #Down
            41   36  37 2
            42   25  38 1 #Up

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