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KEGG   DRUG: Omeprazole, clarithromycin and amoxicillin
Entry
D10246            Mixture   Drug                                   
Name
Omeprazole, clarithromycin and amoxicillin;
Omeclamox-pak (TN)
Component
Omeprazole [DR:D00455], Clarithromycin [DR:D00276], (Amoxicillin hydrate [DR:D00229] | Amoxicillin [DR:D07452])
Class
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Transporter inhibitor
 DG01622  ABCB1 inhibitor
Remark
ATC code: A02BD05
Efficacy
Antibacterial
  Disease
Helicobacter pylori infection [DS:H00320]
Comment
Omeprazole is metabolized by CYP2C19 with some contribution from CYP3A4.
Clarithromycin is an inhibitor and a substrate of CYP3A4, and it is an inhibitor of P-gp.
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A4 [HSA:1576]
Transporter inhibition: ABCB1 [HSA:5243]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD05 Omeprazole, amoxicillin and clarithromycin
      D10246  Omeprazole, clarithromycin and amoxicillin
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Amoxicillin/ Clarithromycin/ Omeprazole
    D10246  Omeprazole, clarithromycin and amoxicillin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D10246  Omeprazole, clarithromycin and amoxicillin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10246  Omeprazole, clarithromycin and amoxicillin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    D10246  Omeprazole, clarithromycin and amoxicillin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   D10246  Omeprazole, clarithromycin and amoxicillin
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Combination for eradication of H. pylori
    D10246  Omeprazole, clarithromycin and amoxicillin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10246
 Drug transporters
  D10246
Other DBs
PubChem: 163312277
LinkDB

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