| Entry |
|
|---|
| Name |
Rosuvastatin (INN);
Creston (TN) |
|---|
| Formula |
C22H28FN3O6S
|
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| Exact mass |
481.1683
|
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| Mol weight |
481.54
|
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| Structure |
|
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Transporter substrate
DG01913 ABCG2 substrate
DG02856 SLCO1B1 substrate
|
|---|
| Remark |
| Product (DG00357): | D01915<JP/US> |
| Product (mixture): | D11520<JP> |
|
|---|
| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
|---|
| Target |
|
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
|
|---|
| Metabolism |
Transporter: SLCO1B1 [HSA: 10599], ABCG2 [HSA: 9429]
|
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| Interaction |
|
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| Structure map |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA07 Rosuvastatin
D08492 Rosuvastatin (INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00357 Rosuvastatin
D08492 Rosuvastatin
Transporter substrate
DG01913 ABCG2 substrate
DG00357 Rosuvastatin
D08492 Rosuvastatin
DG02856 SLCO1B1 substrate
DG00357 Rosuvastatin
D08492 Rosuvastatin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D08492 Rosuvastatin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08492
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00357 Rosuvastatin
Transporter substrate
DG01913 ABCG2 substrate
DG00357 Rosuvastatin
DG02856 SLCO1B1 substrate
DG00357 Rosuvastatin
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 33
1 C8y C 24.1500 -19.4600
2 N5x N 24.1500 -20.8600
3 C8y C 25.3400 -21.5600
4 N5x N 26.6000 -20.8600
5 C8y C 26.6000 -19.4600
6 C8y C 25.3400 -18.7600
7 C1c C 27.7900 -18.7600
8 C1a C 28.9800 -19.4600
9 C1a C 27.7900 -17.3600
10 C2b C 25.3400 -17.3600
11 C2b C 26.6000 -16.6600
12 C1c C 26.6000 -15.2600
13 O1a O 27.7900 -14.5600
14 C1b C 25.3400 -14.5600
15 C1c C 25.3400 -13.1600
16 O1a O 24.1500 -12.4600
17 C1b C 26.6000 -12.4600
18 C6a C 28.0000 -12.4600
19 O6a O 28.7000 -11.2700
20 O6a O 28.7000 -13.6500
21 N1c N 25.3400 -22.9600
22 S4a S 26.6000 -23.6600
23 C1a C 24.1500 -23.6600
24 C1a C 27.7900 -22.9600
25 O3c O 25.6200 -24.6400
26 O3c O 27.5800 -24.6400
27 C8y C 22.9600 -18.7600
28 C8x C 22.9600 -17.3600
29 C8x C 21.7000 -16.6600
30 C8y C 20.5100 -17.3600
31 C8x C 20.5100 -18.7600
32 C8x C 21.7000 -19.4600
33 X F 19.3200 -16.6600
BOND 34
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 7 9 1
10 6 10 1
11 10 11 2
12 12 11 1 #Down
13 12 13 1
14 12 14 1
15 14 15 1
16 15 16 1 #Up
17 15 17 1
18 17 18 1
19 18 19 2
20 18 20 1
21 3 21 1
22 21 22 1
23 21 23 1
24 22 24 1
25 22 25 2
26 22 26 2
27 1 27 1
28 27 28 2
29 28 29 1
30 29 30 2
31 30 31 1
32 31 32 2
33 27 32 1
34 30 33 1
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