| Entry |
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| Name |
Dexamethasone cipecilate (JAN/INN) |
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| Formula |
C33H43FO7
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| Exact mass |
570.2993
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| Mol weight |
570.69
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
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| Remark |
| Therapeutic category: | 1329 |
| Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
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| Efficacy |
Antiallergic, Anti-inflammatory, Glucocorticoid receptor agonist |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576]
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
132 Otic and nasal agents
1329 Others
D07073 Dexamethasone cipecilate (JAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07073 Dexamethasone cipecilate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07073 Dexamethasone cipecilate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07073 Dexamethasone cipecilate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D07073 Dexamethasone cipecilate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07073 Dexamethasone cipecilate (JAN/INN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D07073
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07073
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 41
1 C2x C 21.1400 -21.0000
2 C5x C 21.1400 -22.3300
3 C2x C 22.3300 -23.0300
4 C2y C 23.5200 -22.3300
5 C1z C 23.5200 -21.0000
6 C2x C 22.3300 -20.3000
7 C1x C 24.6400 -23.0300
8 C1x C 25.8300 -22.3300
9 C1y C 25.8300 -21.0000
10 C1z C 24.6400 -20.3000
11 C1y C 27.0200 -20.3000
12 C1z C 27.0200 -18.9700
13 C1x C 25.8300 -18.3400
14 C1y C 24.6400 -18.9700
15 C1x C 29.3300 -20.3000
16 C1y C 29.3300 -18.9700
17 C1z C 28.1400 -18.3400
18 C1a C 23.5200 -19.6700
19 C1a C 27.0200 -17.6400
20 C1a C 30.4500 -18.3400
21 C5a C 28.1400 -16.6600
22 X F 24.6400 -21.7000
23 O7a O 29.8900 -17.2200
24 O5x O 20.0200 -23.0300
25 O5a O 29.3300 -15.9600
26 C1b C 27.0200 -15.9600
27 O7a O 25.8300 -16.6600
28 C7a C 31.2200 -17.2200
29 O6a O 31.9200 -18.4100
30 C1y C 31.9200 -16.0300
31 C7a C 24.6400 -15.9600
32 O6a O 24.6400 -14.5600
33 C1y C 23.4500 -16.6600
34 C1x C 22.7500 -15.4700
35 C1x C 21.3500 -15.4700
36 C1x C 20.6500 -16.6600
37 C1x C 21.3500 -17.8500
38 C1x C 22.7500 -17.8500
39 C1x C 33.3722 -15.8020
40 C1x C 32.4961 -14.7350
41 O1a O 24.6400 -17.5700
BOND 46
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 5 18 1 #Up
22 12 19 1 #Up
23 16 20 1 #Down
24 17 21 1 #Up
25 10 22 1 #Down
26 17 23 1 #Down
27 2 24 2
28 21 25 2
29 21 26 1
30 26 27 1
31 23 28 1
32 28 29 2
33 28 30 1
34 27 31 1
35 31 32 2
36 31 33 1
37 33 34 1
38 34 35 1
39 35 36 1
40 36 37 1
41 37 38 1
42 33 38 1
43 30 39 1
44 39 40 1
45 40 30 1
46 14 41 1 #Up
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