| Entry |
|
|---|
| Name |
Flunisolide acetate (USAN) |
|---|
| Formula |
C26H33FO7
|
|---|
| Exact mass |
476.2210
|
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| Mol weight |
476.53
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01040): | D00324<US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD04 Flunisolide
D04214 Flunisolide acetate (USAN)
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA03 Flunisolide
D04214 Flunisolide acetate (USAN)
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Flunisolide
D04214 Flunisolide acetate (USAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG01040 Flunisolide
D04214 Flunisolide acetate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01040 Flunisolide
D04214 Flunisolide acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D04214 Flunisolide acetate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04214
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG01040 Flunisolide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01040 Flunisolide
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C2x C 26.4600 -16.5900
2 C5x C 26.4600 -17.9200
3 C2x C 27.6500 -18.6200
4 C2y C 28.8400 -17.9200
5 C1z C 28.8400 -16.5900
6 C2x C 27.6500 -15.8900
7 C1y C 30.0300 -18.6200
8 C1x C 31.2200 -17.9200
9 C1y C 31.2200 -16.5900
10 C1y C 30.0300 -15.8900
11 C1y C 32.4800 -15.8900
12 C1z C 32.4800 -14.4900
13 C1x C 31.2200 -13.7900
14 C1y C 30.0300 -14.4900
15 C1x C 33.7400 -16.3100
16 C1y C 34.5800 -15.1900
17 C1z C 33.7400 -14.0700
18 O5x O 25.2700 -18.6200
19 C1a C 28.8400 -15.1900
20 O1a O 28.8400 -13.7900
21 C1a C 32.4800 -13.0900
22 X F 30.0300 -20.0200
23 O2x O 35.9100 -14.7700
24 C1z C 35.9100 -13.3700
25 O2x O 34.5800 -12.9500
26 C1a C 35.9100 -11.9700
27 C1a C 37.3100 -13.3700
28 C5a C 33.7400 -11.9700
29 O5a O 35.0000 -11.2700
30 C1b C 32.6200 -11.3400
31 O7a O 31.4300 -11.9700
32 C7a C 30.2441 -11.2260
33 C1a C 29.0145 -11.8768
34 O6a O 30.2266 -9.8011
BOND 38
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 7 22 1 #Down
26 16 23 1 #Down
27 23 24 1
28 24 25 1
29 17 25 1 #Down
30 24 26 1
31 24 27 1
32 17 28 1 #Up
33 28 29 2
34 28 30 1
35 30 31 1
36 31 32 1
37 32 33 1
38 32 34 2
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