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KEGG   DRUG: Apixaban
Entry
D03213                      Drug                                   
Name
Apixaban (JAN/USAN/INN);
Eliquis (TN)
Product
ELIQUIS (A-S Medication Solutions), ELIQUIS (A-S Medication Solutions), ELIQUIS (A-S Medication Solutions), ELIQUIS (Aphena Pharma Solutions - Tennessee), ELIQUIS (Aphena Pharma Solutions - Tennessee), ELIQUIS (Bryant Ranch Prepack), ELIQUIS (Bryant Ranch Prepack), ELIQUIS (Cardinal Health 107), ELIQUIS (E.R. Squibb & Sons), ELIQUIS (Pharmasource Meds), ELIQUIS (Proficient Rx LP), ELIQUIS (REMEDYREPACK), ELIQUIS (RedPharm Drug)
  Generic
APIXABAN (Indoco Remedies Limited)
Formula
C25H25N5O4
Exact mass
459.1907
Mol weight
459.50
Structure
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
  DG03320  Direct oral anticoagulant (DOAC)
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Transporter substrate
 DG01665  ABCB1 substrate
 DG01913  ABCG2 substrate
Remark
Therapeutic category: 3339
ATC code: B01AF02
Product: D03213<JP/US>
Efficacy
Anticoagulant, Antithrombotic, Factor Xa inhibitor
  Disease
Deep vein thrombosis [DS:H01723]
Target
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
  Network
nt06514  Coagulation cascade
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Structure map
map07049  Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AF Direct factor Xa inhibitors
     B01AF02 Apixaban
      D03213  Apixaban (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Anticoagulants
   Factor Xa Inhibitors, Direct
    Apixaban
     D03213  Apixaban (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   333  Anticoagulants
    3339  Others
     D03213  Apixaban (JAN/USAN/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01662  Factor Xa inhibitor
    D03213  Apixaban
   DG03320  Direct oral anticoagulant (DOAC)
    D03213  Apixaban
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D03213  Apixaban
  DG02925  CYP3A5 substrate
   D03213  Apixaban
 Transporter substrate
  DG01665  ABCB1 substrate
   D03213  Apixaban
  DG01913  ABCG2 substrate
   D03213  Apixaban
Drug classes [BR:br08332]
 Anticoagulant
  DG03320  Direct oral anticoagulant (DOAC)
   D03213  Apixaban
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F10
     D03213  Apixaban (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03213
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03213
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03213
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03213
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03213
 Drug transporters
  D03213
Other DBs
CAS: 503612-47-3
PubChem: 17397366
ChEBI: 72296
PDB-CCD: GG2[PDBj]
LigandBox: D03213
NIKKAJI: J2.566.952E
LinkDB
KCF data

ATOM        34
            1   C1x C    21.2579  -15.3879
            2   C1x C    21.2579  -16.7863
            3   C5x C    22.4689  -17.4855
            4   N1y N    23.6799  -16.7863
            5   C1x C    23.6799  -15.3879
            6   C1x C    22.4689  -14.6887
            7   C8y C    24.9097  -17.4965
            8   C8x C    24.9094  -18.8839
            9   C8x C    26.1203  -19.5833
            10  C8y C    27.3315  -18.8845
            11  C8x C    27.3318  -17.4971
            12  C8x C    26.1209  -16.7976
            13  N1y N    28.5492  -19.5878
            14  C1x C    28.5489  -20.9815
            15  C1x C    29.7597  -21.6809
            16  C8y C    30.9709  -20.9822
            17  C8y C    30.9714  -19.5886
            18  C5x C    29.7605  -18.8890
            19  O5x O    22.4689  -18.8838
            20  O5x O    29.7609  -17.4858
            21  C8y C    32.2962  -21.4131
            22  N5x N    33.1156  -20.2860
            23  N4y N    32.2968  -19.1583
            24  C8y C    32.7204  -17.8544
            25  C5a C    32.7279  -22.7430
            26  N1a N    34.1279  -22.7430
            27  O5a O    31.9130  -23.8647
            28  C8x C    34.1204  -17.8544
            29  C8x C    34.8204  -16.6420
            30  C8y C    34.1204  -15.4296
            31  C8x C    32.7204  -15.4296
            32  C8x C    32.0204  -16.6420
            33  O2a O    34.8256  -14.2088
            34  C1a C    36.2600  -14.2091
BOND        38
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 1
            21    3  19 2
            22   18  20 2
            23   16  21 1
            24   21  22 2
            25   22  23 1
            26   17  23 1
            27   23  24 1
            28   21  25 1
            29   25  26 1
            30   25  27 2
            31   24  28 1
            32   28  29 2
            33   29  30 1
            34   30  31 2
            35   31  32 1
            36   24  32 2
            37   30  33 1
            38   33  34 1

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