 | | DRUG: Sertraline hydrochloride | |
| Entry |
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| Name |
Sertraline hydrochloride (JAN/USP);
Zoloft (TN) |
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| Product |
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| Generic |
SERTRALINE (A-S Medication Solutions), SERTRALINE (A-S Medication Solutions), SERTRALINE (A-S Medication Solutions), SERTRALINE (A-S Medication Solutions), SERTRALINE (A-S Medication Solutions), SERTRALINE (Aphena Pharma Solutions - Tennessee), SERTRALINE (Aphena Pharma Solutions - Tennessee), SERTRALINE (AvPAK), SERTRALINE (Bryant Ranch Prepack), SERTRALINE (Bryant Ranch Prepack), SERTRALINE (Cardinal Health 107), SERTRALINE (Exelan Pharmaceuticals), SERTRALINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), SERTRALINE (Lupin Pharmaceuticals), SERTRALINE (Major Pharmaceuticals), SERTRALINE (NuCare Pharmaceuticals), SERTRALINE (NuCare Pharmaceuticals), SERTRALINE (Preferred Pharmaceuticals), SERTRALINE (Preferred Pharmaceuticals), SERTRALINE (Proficient Rx LP), SERTRALINE (Quality Care Products), SERTRALINE (REMEDYREPACK), SERTRALINE (REMEDYREPACK), SERTRALINE HCL (Direct_Rx), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (A-S Medication Solutions), SERTRALINE HYDROCHLORIDE (ACI Healthcare USA), SERTRALINE HYDROCHLORIDE (ACI Healthcare USA), SERTRALINE HYDROCHLORIDE (Accord Healthcare), SERTRALINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), SERTRALINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), SERTRALINE HYDROCHLORIDE (American Health Packaging), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), SERTRALINE HYDROCHLORIDE (Ascent Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Asclemed USA), SERTRALINE HYDROCHLORIDE (Aurobindo Pharma Limited), SERTRALINE HYDROCHLORIDE (Aurobindo Pharma Limited), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Bryant Ranch Prepack), SERTRALINE HYDROCHLORIDE (Camber Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Cardinal Health 107), SERTRALINE HYDROCHLORIDE (Cipla USA), SERTRALINE HYDROCHLORIDE (Coupler LLC), SERTRALINE HYDROCHLORIDE (Coupler LLC), SERTRALINE HYDROCHLORIDE (DIRECT RX), SERTRALINE HYDROCHLORIDE (Granules Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Greenstone LLC), SERTRALINE HYDROCHLORIDE (Legacy Pharmaceutical Packaging), SERTRALINE HYDROCHLORIDE (NCS HealthCare of KY), SERTRALINE HYDROCHLORIDE (NorthStar Rx LLC), SERTRALINE HYDROCHLORIDE (NorthStar Rx LLC), SERTRALINE HYDROCHLORIDE (Northwind Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Northwind Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Northwind Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (NuCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Pharmasource Meds), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Preferred Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (Proficient Rx LP), SERTRALINE HYDROCHLORIDE (QPharma), SERTRALINE HYDROCHLORIDE (QPharma), SERTRALINE HYDROCHLORIDE (Quality Care Products LLC), SERTRALINE HYDROCHLORIDE (Quality Care Products), SERTRALINE HYDROCHLORIDE (Quality Care Products), SERTRALINE HYDROCHLORIDE (Quallent Pharmaceuticals Health LLC), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (REMEDYREPACK), SERTRALINE HYDROCHLORIDE (Rising Pharma Holdings), SERTRALINE HYDROCHLORIDE (ST. MARY'S MEDICAL PARK PHARMACY), SERTRALINE HYDROCHLORIDE (ScieGen Pharmaceuticals), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), SERTRALINE HYDROCHLORIDE (XLCare Pharmaceuticals), SERTRALINE HYDROCHLORIDE (Zydus Lifesciences Limited) |
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| Formula |
C17H17Cl2N. HCl
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| Exact mass |
341.0505
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| Mol weight |
342.69
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1179 |
| Product (DG00945): | D00825<JP/US> |
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| Efficacy |
Antidepressant, Selective serotonin reuptake inhibitor (SSRI) |
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| Disease |
Major depressive disorder [DS: H01646] Obsessive-compulsive disorder [DS: H01450] Panic disorder [DS: H01664] Social anxiety disorder [DS: H01670] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557], CYP2C9 [HSA: 1559], CYP2B6 [HSA: 1555], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB06 Sertraline
D00825 Sertraline hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Sertraline
D00825 Sertraline hydrochloride (JAN/USP)
Anxiolytics
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Sertraline
D00825 Sertraline hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00825 Sertraline hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00945 Sertraline
D00825 Sertraline hydrochloride
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG00945 Sertraline
D00825 Sertraline hydrochloride
DG01642 CYP2C9 substrate
DG00945 Sertraline
D00825 Sertraline hydrochloride
DG01639 CYP2C19 substrate
DG00945 Sertraline
D00825 Sertraline hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00945 Sertraline
D00825 Sertraline hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
D00825 Sertraline hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D00825 Sertraline hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00825
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00825
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00945 Sertraline
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG00945 Sertraline
DG01642 CYP2C9 substrate
DG00945 Sertraline
DG01639 CYP2C19 substrate
DG00945 Sertraline
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00945 Sertraline
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 21
1 C8y C 25.3101 -16.0857
2 C1y C 26.5154 -16.7935
3 C8y C 25.3160 -14.6932
4 C8x C 24.1107 -16.7877
5 C8y C 26.5095 -18.1919
6 C1x C 27.7382 -16.0974
7 C1y C 26.5271 -13.9969
8 C8x C 24.1107 -13.9912
9 C8x C 22.8939 -16.0857
10 C8x C 25.3043 -18.8822
11 C8x C 27.7322 -18.8938
12 C1x C 27.7439 -14.6990
13 N1b N 26.5329 -12.5930
14 C8x C 22.8939 -14.6932
15 C8y C 25.2984 -20.2862
16 C8x C 27.7265 -20.2979
17 C1a C 27.7556 -11.8967
18 C8y C 26.5037 -20.9883
19 X Cl 24.0816 -20.9825
20 X Cl 26.4977 -22.3867
21 X Cl 31.2546 -18.4534
BOND 22
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1 #Up
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 2
10 5 11 1
11 6 12 1
12 7 13 1 #Up
13 8 14 1
14 10 15 1
15 11 16 2
16 13 17 1
17 15 18 2
18 15 19 1
19 18 20 1
20 7 12 1
21 9 14 2
22 16 18 1
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