| Entry |
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| Name |
Imipramine hydrochloride (JP18/USP);
Tofranil (TN) |
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| Product |
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| Generic |
IMIPRAMINE HYDROCHLORIDE (A-S Medication Solutions), IMIPRAMINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), IMIPRAMINE HYDROCHLORIDE (Advanced Rx Pharmacy of Tennessee), IMIPRAMINE HYDROCHLORIDE (Key Therapeutics), IMIPRAMINE HYDROCHLORIDE (Leading Pharma), IMIPRAMINE HYDROCHLORIDE (Lupin Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (NuCare Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (Oxford Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), IMIPRAMINE HYDROCHLORIDE (Proficient Rx LP), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (REMEDYREPACK), IMIPRAMINE HYDROCHLORIDE (Strides Pharma Science Limited) |
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| Formula |
C19H24N2. HCl
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| Exact mass |
316.1706
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| Mol weight |
316.87
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1174 |
| Product (DG00928): | D00815<JP/US> D08071<US> |
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
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| Disease |
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| Comment |
Active form of prodrug: Desipramine [DR: D07791]
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557]
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| Interaction |
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| Structure map |
| map07213 | Dopamine receptor agonists/antagonists |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA02 Imipramine
D00815 Imipramine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
Tricyclics
Imipramine
D00815 Imipramine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1174 Imipramines
D00815 Imipramine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00928 Imipramine
D00815 Imipramine hydrochloride
DG01728 Tricyclic antidepressant
DG00928 Imipramine
D00815 Imipramine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00928 Imipramine
D00815 Imipramine hydrochloride
DG01639 CYP2C19 substrate
DG00928 Imipramine
D00815 Imipramine hydrochloride
DG01644 CYP2D6 substrate
DG00928 Imipramine
D00815 Imipramine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00928 Imipramine
D00815 Imipramine hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D00815 Imipramine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D00815 Imipramine hydrochloride (JP18/USP) <JP/US>
SLC6A4 (HTT)
D00815 Imipramine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00815 Imipramine hydrochloride
D00815 Imipramine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00815
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00815
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00928 Imipramine
DG01728 Tricyclic antidepressant
DG00928 Imipramine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00928 Imipramine
DG01639 CYP2C19 substrate
DG00928 Imipramine
DG01644 CYP2D6 substrate
DG00928 Imipramine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00928 Imipramine
Prodrugs [br08324.html]
DG00928
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C1x C 12.8734 -13.8694
2 C8y C 12.0313 -12.7598
3 C8y C 12.3665 -11.4030
4 N1y N 13.6275 -10.8249
5 C1x C 14.2792 -13.8946
6 C8y C 14.8811 -11.4472
7 C8y C 15.1676 -12.8159
8 C8x C 11.3594 -10.4346
9 C8x C 10.0174 -10.8227
10 C8x C 9.6822 -12.1795
11 C8x C 10.6893 -13.1476
12 C8x C 16.4988 -13.2530
13 C8x C 17.5430 -12.3186
14 C8x C 17.2566 -10.9499
15 C8x C 15.9252 -10.5128
16 C1b C 13.6492 -9.4500
17 C1b C 14.8732 -8.7689
18 C1b C 16.0416 -9.4684
19 N1c N 17.2637 -8.7883
20 C1a C 18.4984 -9.5269
21 C1a C 17.2857 -7.4200
22 X Cl 20.1600 -11.7600
BOND 23
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 19 21 1
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