KEGG ENZYME: 2.3.3.16

ENZYME: 2.3.3.16

Entry

EC 2.3.3.16                 Enzyme

Name

citrate synthase (unknown stereospecificity);
citrate condensing enzyme;
CoA-acetylating citrate oxaloacetate-lyase;
citrate synthetase;
citric synthase;
citric-condensing enzyme;
citrogenase;
condensing enzyme (ambiguous);
oxaloacetate transacetase;
oxalacetic transacetase

Class

Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer

Sysname

acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

Reaction(IUBMB)

acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]

Reaction(KEGG)

R00351

Substrate

acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
oxaloacetate [CPD:C00036]

Product

citrate [CPD:C00158];
CoA [CPD:C00010]

Comment

This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C-2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].

History

EC 2.3.3.16 created 2014

Reference

1 [PMID:3130075]

Authors

Lohlein-Werhahn G, Goepfert P, Eggerer H

Title

Purification and properties of an archaebacterial enzyme: citrate synthase from Sulfolobus solfataricus.

Journal

Biol Chem Hoppe Seyler 369:109-13 (1988)
DOI:10.1515/bchm3.1988.369.1.109

Reference

2 [PMID:8997706]

Authors

Sievers M, Stockli M, Teuber M

Title

Purification and properties of citrate synthase from Acetobacter europaeus.

Journal

FEMS Microbiol Lett 146:53-8 (1997)
DOI:10.1111/j.1574-6968.1997.tb10170.x

Reference

3 [PMID:9113733]

Authors

Belova LL, Sokolov AP, Morgunov IG, Trotsenko YuA

Title

Purification and characterization of citrate synthase from Methylobacterium extorquens--a methylotrophic producer of polyhydroxybutyrate.

Journal

Biochemistry (Mosc) 62:71-6 (1997)

Reference

4 [PMID:9387145]

Authors

Lee S, Park C, Yim J

Title

Characterization of citrate synthase purified from Drosophila melanogaster.

Journal

Mol Cells 7:599-604 (1997)

Reference

5 [PMID:12741811]

Authors

Maurus R, Nguyen NT, Stokell DJ, Ayed A, Hultin PG, Duckworth HW, Brayer GD

Title

Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases.

Journal

Biochemistry 42:5555-65 (2003)
DOI:10.1021/bi020622s

Sequence

[eco:b0720]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.3.16

IUBMB Enzyme Nomenclature:

2.3.3.16

ExPASy - ENZYME nomenclature database:

2.3.3.16

BRENDA, the Enzyme Database:

2.3.3.16

LinkDB

DBGET integrated database retrieval system