| Entry |
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| Name |
3'-N-debenzoyltaxol N-benzoyltransferase;
DBTNBT;
3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
benzoyl-CoA:3'-N-debenzoyltaxol 3'-N-benzoyltransferase
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| Reaction(IUBMB) |
benzoyl-CoA + 3'-N-debenzoyltaxol = CoA + paclitaxel [RN: R08171]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme, present in Taxus species (yew) catalyses the final step in paclitaxel (Taxol) biosynthesis.
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| History |
EC 2.3.1.321 created 2024
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K27850 | 3'-N-debenzoyltaxol N-benzoyltransferase |
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| Genes |
| CJF: | 131036108 131057048 131061338 131061339 131063160 131064149 131064150 131064151 131064161 131064181 131065005 131072850 131072870 131072871 |
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| Reference |
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| Authors |
Walker K, Long R, Croteau R. |
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| Title |
The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Long RM, Lagisetti C, Coates RM, Croteau RB. |
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| Title |
Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis. |
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| Journal |
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| Reference |
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| Authors |
Zhang Y, Wiese L, Fang H, Alseekh S, Perez de Souza L, Scossa F, Molloy J, Christmann M, Fernie AR. |
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| Title |
Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.321 |
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| LinkDB |
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