KEGG ENZYME: 1.14.11.72

ENZYME: 1.14.11.72

Entry

EC 1.14.11.72               Enzyme

Name

[2-(trimethylamino)ethyl]phosphonate dioxygenase;
tmpA (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

Sysname

[2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating)

Reaction(IUBMB)

[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2 [RN:R12615]

Reaction(KEGG)

R12615

Substrate

[2-(trimethylamino)ethyl]phosphonate [CPD:C22281];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]

Product

[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate [CPD:C22271];
succinate [CPD:C00042];
CO2 [CPD:C00011]

Comment

Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.

History

EC 1.14.11.72 created 2020

Orthology

K24291

[2-(trimethylamino)ethyl]phosphonate dioxygenase

Genes

PBEZ:

SBP02_13565

MARJ:

MARI_16720

MOQ:	HWV03_17260

PAQM:

E0F26_05775 E0F26_06635

SHAI:

LMH63_14695

CCAG:

SR908_07940

HAF:	C8233_04175

HASH:

HXW73_04270 HXW73_04280

HPIS:

P1P91_13960 P1P91_14455 P1P91_14530

HNP:	SR894_19700 SR894_19760

CAMH:

LCW13_07215

COBB:

H2O77_07230

COBD:

U0O11_06785

MARS:

A8C75_09130

MRZ:	KDW95_08530

TSN:	W908_07695

THIN:

CRN91_02445

PMEG:

FNZ07_29585

PPAI:

E1956_08225

MLO:

mll1440

MLN:	A9174_18900

MCI:	Mesci_3237

MCIC:

A4R28_10585

MOP:	Mesop_3629

MAM:	Mesau_03502

MAMO:

A6B35_22570

MESW:

A9K65_017530

MESP:

C1M53_13015

MHUA:

MCHK_3077

MJR:	EB229_19185

MERD:

EB233_16530

MOH:	IHQ72_17265

MMEI:

LRP31_11945

MESJ:

MJ8_41900

MESI:

LGH82_32885

MESU:

LHFGNBLO_003220

PHYL:

HB779_23160

RLS:	HB780_09245

HOE:	IMCC20628_01348

LNE:	FZC33_24920

NOH:	G5V57_30915

LABR:

CHH27_03690

LABP:

FJ695_19965

RPOP:

K1718_10220

SIL:

SPO3380

SIT:	TM1040_0333

RUA:	D1823_16315

RUT:	FIU92_15150

RCON:

K3740_16490

RUY:	NOR97_14090

PGA:	PGA1_c27220

PGL:	PGA2_c25240

PGD:

Gal_00705

PHP:	PhaeoP97_02668

PPIC:

PhaeoP14_02470

PHQ:	D1820_08325

PHAE:

N1037_10095

OCT:	FTO60_03580

LMD:	METH_08250

LEJ:	ETW24_09560

LAQU:

R2C4_08480

LEV:	ETW23_09420

LCAE:

K3721_08720

LEIM:

K3557_08740

SULZ:

C1J03_21470

SULI:

C1J05_15870

ROM:	EI983_17985

RPEL:

N7U68_11415

RPHC:

RZ517_00415

RRL:	RZS32_008265

LALG:

LentiSH36_00731

TSCO:

R1T40_04525 R1T40_13870

YRH:	AABB31_15690

SEDI:

EBB79_01655

PPSO:

QPJ95_14615

PSEB:

EOK75_16310

PAED:

G5B38_12540

CACT:

HZ995_05375

ACRO:

K3J57_14495

AMYL:

QBD29_06795

RHOC:

QTA57_03285 QTA57_08995

LVR:	T8T21_12360

ALTC:

P7228_15335

THAR:

T8K17_21070 T8K17_21105

PAQI:

KW060_01785

SNEA:

NBZ79_11455 NBZ79_16040

NSPH:

BDGGKGIB_02714

» show all

Reference

1 [PMID:30789718]

Authors

Rajakovich LJ, Pandelia ME, Mitchell AJ, Chang WC, Zhang B, Boal AK, Krebs C, Bollinger JM Jr

Title

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.

Journal

Biochemistry 58:1627-1647 (2019)
DOI:10.1021/acs.biochem.9b00044

Sequence

[ag:WP_027237574]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.11.72

IUBMB Enzyme Nomenclature:

1.14.11.72

ExPASy - ENZYME nomenclature database:

1.14.11.72

BRENDA, the Enzyme Database:

1.14.11.72

LinkDB

DBGET integrated database retrieval system