Entry
Name
gamma-glutamylanilide synthase;
atdA1 (gene name);
tdnQ (gene name);
dcaQ (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
L-glutamate:aniline ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine [RN:
R10772 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.
History
EC 6.3.1.18 created 2014
Orthology
K20419 gamma-glutamylanilide synthase
Reference
Authors
Takeo M, Ohara A, Sakae S, Okamoto Y, Kitamura C, Kato D, Negoro S
Title
Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.18
ExPASy - ENZYME nomenclature database: 6.3.1.18