KEGG ENZYME: 3.2.1.105

ENZYME: 3.2.1.105

Entry

EC 3.2.1.105                Enzyme

Name

3alpha(S)-strictosidine beta-glucosidase

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

strictosidine beta-D-glucohydrolase

Reaction(IUBMB)

strictosidine + H2O = D-glucose + strictosidine aglycone [RN:R03820]

Reaction(KEGG)

R03820

Substrate

strictosidine [CPD:C03470];
H2O [CPD:C00001]

Product

D-glucose [CPD:C00031];
strictosidine aglycone [CPD:C03309]

Comment

Does not act on a number of closely related glycosides. Strictosidine is a precursor of indole alkaloids.

History

EC 3.2.1.105 created 1984

Pathway

ec00901

Indole alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12693

strictosidine beta-D-glucosidase

Reference

1 [PMID:6768587]

Authors

Hemscheidt T, Zenk MH.

Title

Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures.

Journal

FEBS Lett 110:187-91 (1980)
DOI:10.1016/0014-5793(80)80069-X

Reference

2 [PMID:15680242]

Authors

Barleben L, Ma X, Koepke J, Peng G, Michel H, Stockigt J.

Title

Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons.

Journal

Biochim Biophys Acta 1747:89-92 (2005)
DOI:10.1016/j.bbapap.2004.09.026

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.105

IUBMB Enzyme Nomenclature:

3.2.1.105

ExPASy - ENZYME nomenclature database:

3.2.1.105

BRENDA, the Enzyme Database:

3.2.1.105

CAS:	73379-57-4

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