Entry
Name
4-hydroxybenzoyl-CoA reductase;
4-hydroxybenzoyl-CoA reductase (dehydroxylating);
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase;
benzoyl-CoA:acceptor oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
benzoyl-CoA:oxidized ferredoxin oxidoreductase
Reaction(IUBMB)
benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin [RN:
R05316 ]
Reaction(KEGG)
Substrate
Product
4-hydroxybenzoyl-CoA [CPD:
C02949 ];
reduced ferredoxin [CPD:
C00138 ]
Comment
A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].
History
EC 1.1.7.1 created 2000 as EC 1.3.99.20, transferred 2011 to EC 1.3.7.9, transferred 2020 to EC 1.1.7.1
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K04107 4-hydroxybenzoyl-CoA reductase subunit gamma
K04108 4-hydroxybenzoyl-CoA reductase subunit alpha
K04109 4-hydroxybenzoyl-CoA reductase subunit beta
Genes
EBA : ebA3602(hcrB) ebA3603(hcrA) ebA3604(hcrC)
ABRE : pbN1_21960(hcrB) pbN1_21970(hcrA) pbN1_21980(hcrC)
APET : ToN1_29630(hcrB) ToN1_29640(hcrA) ToN1_29650(hcrC)
AZA : AZKH_0489(hcrB) AZKH_0490(hcrA) AZKH_0491(hcrC)
AZI : AzCIB_0406 AzCIB_0407 AzCIB_0408
AZD : CDA09_02105(hcrB) CDA09_02110(hcrA) CDA09_02115(hcrC)
TMZ : Tmz1t_0224 Tmz1t_0225 Tmz1t_0226
TCL : Tchl_2357 Tchl_2358 Tchl_2359
TAK : Tharo_1513 Tharo_1514 Tharo_1515
DDZ : DSYM_17590 DSYM_17600 DSYM_17610
RPA : TX73_003470(hcrC) TX73_003475(hcrA) TX73_003480(hcrB)
RPC : RPC_1013 RPC_1014 RPC_1015
RPD : RPD_1523 RPD_1524 RPD_1525
RPE : RPE_0589 RPE_0590 RPE_0591
RPT : Rpal_0737 Rpal_0738 Rpal_0739
RPX : Rpdx1_4114 Rpdx1_4115 Rpdx1_4116
MAGX : XM1_2739(hcrC) XM1_2740(hcrA) XM1_2741(hcrB)
MAGN : WV31_19855 WV31_19860 WV31_19865
MAG : amb2019 amb2020 amb2021
PBAP : Pla133_36490(hcrA) Pla133_36500(hcrB_1)
» show all
Taxonomy
Reference
Authors
Glockler R, Tschech A, Fuchs G.
Title
Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species.
Journal
Reference
Authors
Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G.
Title
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica.
Journal
Reference
Authors
Breese K, Fuchs G
Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
Journal
Sequence
Reference
Authors
Brackmann R, Fuchs G.
Title
Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species.
Journal
Reference
Authors
Heider J, Fuchs G.
Title
Anaerobic metabolism of aromatic compounds.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.7.1
ExPASy - ENZYME nomenclature database: 1.1.7.1
BRENDA, the Enzyme Database: 1.1.7.1