ID L5KQH4_PTEAL Unreviewed; 916 AA.
AC L5KQH4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 05-FEB-2025, entry version 52.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 2 {ECO:0000313|EMBL:ELK12968.1};
GN ORFNames=PAL_GLEAN10008013 {ECO:0000313|EMBL:ELK12968.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea;
OC Pteropodidae; Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK12968.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
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DR EMBL; KB030636; ELK12968.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KQH4; -.
DR STRING; 9402.L5KQH4; -.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; L5KQH4; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IEA:TreeGrafter.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:TreeGrafter.
DR CDD; cd15294; 7tmC_GABA-B-R2; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR FunFam; 3.40.50.2300:FF:000072; Gamma-aminobutyric acid type B receptor subunit 2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR041689; GBR2_CC.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF74; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF18455; GBR2_CC; 1.
DR PRINTS; PR01178; GABAB2RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELK12968.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 456..738
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 155..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 103785 MW; A0C9022877D84154 CRC64;
MSPRISQDQQ CPLWKLAMLE KLRKPWNKLF PPCAIGSQKM EQLSFAATTP VLADKKKYPY
FFRTVPSDNA VNPAILKLLK YYQWKRVGTL TQDVQRFSEV RNDLTGVLYG EDIEISDTES
FSNDPCTSVK KLKAPSGLLL SSSCSQLVKM TDTSQGYQEQ RGLGTREEVT HPTRGEDADK
APEKRQHLSL PMEEERMGAC RSPAGKKGQR SEGRTAKLMG NDVRIILGQF DQNMAAKVFC
CAHEENMFGS KYQWIIPGWY EPSWWEQVHT EANSSRCLRK NLLAAMEGYI GVDFEPLSSK
QIKTISGKTP QQYEREYNNK RSGVGPSKFH GYAYDGIWVI AKTLQRAMET LHASSRHQRI
QDFNYTDHTL GRIILNAMNE TNFFGVTGQV VFRNGERMGT IKFTQFQDSR EVKVGEYNAV
ADTLEIINDT IKFQGSEPPK DKTIILEQLR KISLPLYSIL SALTILGMIM ASAFLFFNIK
NRNQKLIKMS SPYMNNLIIL GGMLSYASIF LFGLDGSFVS EKTFETLCTV RTWILTVGYT
TAFGAMFAKT WRVHAIFKNV KMKKKIIKDQ KLLVIVGGML LIDLCILICW QAVDPLRRTV
ERYSMEPDPA GRDISIRPLL EHCENTHMTI WLGIVYAYKG LLMLFGCFLA WETRNVSIPA
LNDSKYIGMS VYNVGIMCII GAAVSFLTRD QPNVQFCIVA LVIIFCSTIT LCLVFVPKLI
TLRTNPDAAT QNRRFQFTQN QKKEDSKTST SVTSVNQAST SRLEGLQSEN HRLRMKITEL
DKDLEEVTMQ LQDTPEKTTY IKQNHYQELN DILNLGNFTE STDGGKAILK NHLDQNPQLQ
WNTTEPSRTC KDPIEDINSP EHIQRRLSLQ LPILHHAYLP SIGGVDASCV SPCVSPTASP
RHRHVPPSFR VMVSGL
//