ID E18_NPVAC Reviewed; 90 AA.
AC P41701;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Protein E18;
DE Short=E18;
GN Name=E18;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus;
OC Alphabaculovirus aucalifornicae.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=8806491; DOI=10.1006/viro.1996.0401;
RA Braunagel S.C., He H., Ramamurthy P., Summers M.D.;
RT "Transcription, translation, and cellular localization of three Autographa
RT californica nuclear polyhedrosis virus structural proteins: ODV-E18, ODV-
RT E35, and ODV-EC27.";
RL Virology 222:100-114(1996).
RN [3]
RP FUNCTION.
RX PubMed=18328526; DOI=10.1016/j.virol.2008.01.039;
RA McCarthy C.B., Theilmann D.A.;
RT "AcMNPV ac143 (odv-e18) is essential for mediating budded virus production
RT and is the 30th baculovirus core gene.";
RL Virology 375:277-291(2008).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=20444894; DOI=10.1128/jvi.00040-10;
RA Wang R., Deng F., Hou D., Zhao Y., Guo L., Wang H., Hu Z.;
RT "Proteomics of the Autographa californica nucleopolyhedrovirus budded
RT virions.";
RL J. Virol. 84:7233-7242(2010).
CC -!- FUNCTION: Component of the polyhedra envelope. Plays an essential role
CC in the budded virus production. {ECO:0000269|PubMed:18328526}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:20444894,
CC ECO:0000269|PubMed:8806491}. Note=Present in both the budded virus (BV)
CC and the occluded virus (OV). The occluded form allows the virus to be
CC transmitted from insect to insect through ingestion of contaminated
CC food while the budded form is responsible for the dissemination of
CC infection throughout the insect host. {ECO:0000269|PubMed:20444894,
CC ECO:0000269|PubMed:8806491}.
CC -!- MISCELLANEOUS: Initially termed ODV-18 since it was found only in
CC occluded viruses. New approaches also found the protein in budded
CC virus. It has therefore been renamed to E18.
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DR EMBL; L22858; AAA66773.1; -; Genomic_DNA.
DR PIR; A72868; A72868.
DR RefSeq; NP_054174.1; NC_001623.1.
DR SMR; P41701; -.
DR GeneID; 1403976; -.
DR KEGG; vg:1403976; -.
DR OrthoDB; 27878at10239; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019655; Baculo_ODV-E18.
DR Pfam; PF10717; ODV-E18; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Viral envelope protein; Virion.
FT CHAIN 1..90
FT /note="Protein E18"
FT /id="PRO_0000132919"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 90 AA; 9558 MW; 416AA44C4CAF279A CRC64;
MIYTDPTTGA TTSTDAPSTN YLNRLTPNMF LTILAVVVII ALIIIFVQSS SNGNSSGGNV
PPNALGGFVN PLNATMRANP FMNTPQRQML
//